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Functional and Morphologic Aspects of Intravitreal Triamcinolone for Uveitis-associated Cystoid Macular Edema

Sponsor
Medical University of Vienna (Other)
Overall Status
Completed
CT.gov ID
NCT01299129
Collaborator
(none)
30
Enrollment
1
Location
24
Duration (Months)
1.3
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Purpose:

To evaluate the effect of intravitreal triamcinolone acetonide (IVTA) on uveitis-associated cystoid macular edema (CME) using high resolution optical coherence tomography (SDOCT) in conjunction with thorough visual function testing.

Methods:

28 patients with uveitis-associated CME were examined before intravitreal triamcinolone injection (IVTA) (v1) and at day 1 (v2), week 1 (v3) and month 1 (v4) after injection. Retinal anatomy was evaluated using Cirrus HD-OCT (Carl Zeiss Meditec). Visual function testing consisted of assessing ETDRS distance visual acuity (VA), reading acuity and reading speed using a standardized German-language test (Radner Reading charts), contrast sensitivity using Pelli-Robson Contrast Sensitivity charts and fundus-controlled microperimetry using the MP-1 Microperimeter (Nidek). Here we utilized a cartesian grid consisting of a central locus and three concentric box-shaped stimulation areas. The changes of retinal anatomy over time were compared to the respective outcome of visual function.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    30 participants
    Observational Model:
    Case-Only
    Time Perspective:
    Prospective
    Official Title:
    Functional and Morphologic Aspects of Intravitreal Triamcinolone for Uveitis-associated Cystoid Macular Edema
    Study Start Date :
    Jun 1, 2009
    Actual Primary Completion Date :
    Jun 1, 2011
    Actual Study Completion Date :
    Jun 1, 2011

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      18 Years and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      No
      Inclusion Criteria:

      • intraocular inflammation

      • able to read

      • 18 years old

      Exclusion Criteria:

      • cataract

      • amblyopia

      • dyslexia

      • already applicated intravitreal triamcinolone for current cystoid macular edema

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 Medical University Vienna Vienna Austria 1090

      Sponsors and Collaborators

      • Medical University of Vienna

      Investigators

      None specified.

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      Marion Munk, Dr. med. univ, Medical University of Vienna
      ClinicalTrials.gov Identifier:
      NCT01299129
      Other Study ID Numbers:
      • 070/2009
      First Posted:
      Feb 18, 2011
      Last Update Posted:
      Dec 29, 2011
      Last Verified:
      Dec 1, 2011
      Keywords provided by Marion Munk, Dr. med. univ, Medical University of Vienna
      Uveitis
      Cystoid macular edema
      microperimetry
      functional visual acuity
      intravitreal triamcinolone
      Additional relevant MeSH terms:
      Macular Edema
      Uveitis
      Edema

      Study Results

      No Results Posted as of Dec 29, 2011