A Pilot Study of Functional Optical Coherence Tomography for Ocular Imaging

• Sponsor: University of California, Irvine (Other)
• Overall Status: Completed
• CT.gov ID: NCT00556114
• Collaborator: Beckman Laser Institute University of California Irvine (Other)
• Enrollment: 23
• Location: 1
• Duration (Months): 78
• Patients Per Site Per Month: 0.3

Study Details

Study Description

Brief Summary

Growing evidence shows that altered blood flow plays a major role in many vision-threatening diseases including glaucoma, diabetic retinopathy, age-related macular degeneration, Central Retinal Vein Occlusion, and Branch Retinal Vein Occlusion. Optical coherence tomography, an established imaging technique use for eye exam in clinical ophthalmology, provides high-resolution cross sectional images of the retina and has increased our ability to understand many eye diseases.

Condition or Disease	Intervention/Treatment	Phase
Glaucoma; Diabetic Retinopathy; Age-Related Macular Degeneration; Central Retinal Vein Occlusion; Branch Retinal Vein Occlusion	Device: Optical Coherence Tomography

Detailed Description

Optical Coherence Tomography is a non-invasive technique use a broadband light source to illuminate the area of study with light in the near infrared spectrum, then obtains static images of tissue structure from interference signals of the back-reflected light.

Optical Coherence Tomography a non-contact, non-invasive means of documenting both tissue structure and blood flow changes in ocular disease and can provide high resolution cross-sectional images of tissue structure, direct visualization of blood flow in blood vessels of the eye.

Study Design

• Study Type: Observational
• Actual Enrollment: 23 participants
• Observational Model: Case-Control
• Time Perspective: Prospective
• Official Title: A Pilot Study of Functional Optical Coherence Tomography for Ocular Imaging
• Study Start Date: Jan 1, 2007
• Actual Primary Completion Date: Jul 1, 2013
• Actual Study Completion Date: Jul 1, 2013

Arms and Interventions

Arm	Intervention/Treatment
Optical Coherence Tomography Optical Coherence Tomography	Device: Optical Coherence Tomography; Optical Coherence Tomography

Outcome Measures

Primary Outcome Measures

1. Medical exam tool [24 hours]

   Optical Coherence Tomography imaging technique of the retina and ability to diagnose and manage many eye diseases

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• Adult 18 years and older with normal eye, or has been diagnosed with eye disease.

Exclusion Criteria:

• Less than 18 years of age.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Beckman Laser Institute, University of California,Irvine	Irvine	California	United States	02612

Sponsors and Collaborators

• University of California, Irvine
• Beckman Laser Institute University of California Irvine

Investigators

• Principal Investigator: Baruch D Kuppermann,, M.D., Ph.D., Ophthamology, University of California,Irvine
• Principal Investigator: Zhongping Chen, Ph,D, Beckman Laser Institute University of California Irvine

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Beckman Laser Institute and Medical Center, Baruch D. Kuppermann, M.D., Ph.D.,Professor Department of Ophthalmology and Biomedical Engineering, University of California, Irvine
• ClinicalTrials.gov Identifier: NCT00556114
• Other Study ID Numbers: NIH-LAMMP-2004-3555
• First Posted: Nov 9, 2007
• Last Update Posted: Feb 10, 2017
• Last Verified: Feb 1, 2017

• Keywords provided by Beckman Laser Institute and Medical Center, Baruch D. Kuppermann, M.D., Ph.D.,Professor Department of Ophthalmology and Biomedical Engineering, University of California, Irvine: eye exam; Retina
• Additional relevant MeSH terms: Macular Degeneration; Diabetic Retinopathy; Retinal Vein Occlusion

Study Results

No Results Posted as of Feb 10, 2017