Gait, cOgnitiOn & Decline (GOOD)
Study Details
Study Description
Brief Summary
The main objective of the GOOD initiative was to determine which spatio-temporal gait parameters and/or combination(s) of spatio-temporal gait parameters best differentiate between cognitively healthy individuals (CHI), patients with mild cognitive impairment (MCI) and those with mild and moderate dementia.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Gait disorders are frequent in individuals with cognitive disorders. However, the profile of spatio-temporal gait parameters in the different cognitive status in aging (from normal cognition to dementia) has been poorly studied. Determining this profile associated with the severity of cognitive disorders may be helpful to understand the complex interplay between gait and cognitive disorders and, thus, may have important implication for the diagnosis process of patients with and without dementia. For instance, defining a motor phenotype of the severity of cognitive disorders by using quantitative gait measurements could be used to improve the prediction and the diagnosis of dementia.
The investigators hypothesized that, compared to CHI, people with MCI and mild dementia could be characterized by specific phenotypes of spatio-temporal gait parameters measured with the GAITRite® system, and that these profiles could be explained by declines in domain-specific cognitive performance.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| cognitively healthy individuals (CHI) CHI were participants without objective cognitive impairment |
Other: gait and cognitive testing
|
| mild cognitive impairment (MCI) MCI was diagnosed if participants met the following criteria: presence of spontaneous cognitive complaints and objective cognitive impairment |
Other: gait and cognitive testing
|
| mild and moderate dementia Diagnoses of dementia were assigned according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV TR, 2000; Association, 2000; 22) at consensus diagnostic case conferences |
Other: gait and cognitive testing
|
Outcome Measures
Primary Outcome Measures
- Spatio-temporal gait parameters [This outcome is assessed at inclusion]
Spatio-temporal gait parameters were measured at steady state walking using GAITRite®-system.
Secondary Outcome Measures
- Clinical assessment [This outcome is assessed at inclusion]
This outcome was assessed by a questionnaire.
- Cognitive status [This outcome is assessed at inclusion]
Cognitive status was assessed by cognitive testing.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Being 60 years old and older
-
Ability to answer questions
Exclusion Criteria:
- Opposition to the use of information collected for research purposes
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University Hospital | Angers | France | 49933 |
Sponsors and Collaborators
- University Hospital, Angers
- Biomathics
Investigators
- Principal Investigator: Olivier Beauchet, MD, PhD, Angers University Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2014-17