GAIT-PD: Gait Control in Parkinson Disease

Sponsor

Université Catholique de Louvain (Other)

Overall Status

Recruiting

CT.gov ID

NCT05908279

Collaborator

(none)

100

Enrollment

Location

Anticipated Duration (Months)

1.9

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Previous work has shown that a statistical property of gait characterised by long-range autocorrelation functions is altered in Parkinson disease (PD). On the other hand it has been suggested that the same property is linked to the ability in healthy humans to co-regulate the amplitude and cadence of strides towards maintaining a constant speed. Here the investigators want to better understand why it is altered in PD by measuring the transitions between gait instructed by a metronome, and gait without metronome. The experimental conditions will allow the comparisons between these transitions across PD and healthy groups of volunteers, and assess differences based on statistical and computational modelling. The link with potential freezing episodes will also be studied to assess whether the statistical determinants of gait control in this population can be used as a proxy or predictor of the occurence of freezing episodes.

Condition or Disease	Intervention/Treatment	Phase
Parkinson Disease	Other: Walking test Other: Disease assessement

Study Design

Study Type:

Observational

Anticipated Enrollment :

100 participants

Observational Model:

Case-Control

Time Perspective:

Prospective

Official Title:

Flexible Control of Gait in Parkinson Disease: Effect of Task Instruction on the Exploitation of Redundancy in Speed Control.

Actual Study Start Date :

May 1, 2023

Anticipated Primary Completion Date :

Oct 31, 2027

Anticipated Study Completion Date :

Oct 31, 2027

Arms and Interventions

Arm	Intervention/Treatment
PD Patients with Parkinson's disease	Other: Walking test Walk with and without a metronome Other: Disease assessement Disease stage assessed by a doctor
Control Healthy volunteers	Other: Walking test Walk with and without a metronome

Arm

Intervention/Treatment

Patients with Parkinson's disease

Other: Walking test

Walk with and without a metronome

Other: Disease assessement

Disease stage assessed by a doctor

Control

Healthy volunteers

Other: Walking test

Walk with and without a metronome

Outcome Measures

Primary Outcome Measures

Stride cadence [Measured during the entire experiment (an average of 4.5 years)]
Time between two consecutive heel strikes. Units are seconds.
Stride amplitude [Measured during the entire experiment (an average of 4.5 years)]
Distance between two consecutive heel strikes. Units are meters.

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 99 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Patients and volunteers able to walk for 20mins and without other neurological disorders.

Exclusion Criteria:

Patients or volunteers unable to walk for 20mins and with other neurological disorders.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Université catholique de Louvain	Louvain-la-Neuve		Belgium	1348

Sponsors and Collaborators

Université Catholique de Louvain

Investigators

Study Director: Frederic Crevecoeur, Université Catholique de Louvain

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Université Catholique de Louvain

ClinicalTrials.gov Identifier:

NCT05908279

Other Study ID Numbers:

GAIT-PD

First Posted:

Jun 18, 2023

Last Update Posted:

Jun 18, 2023

Last Verified:

Jun 1, 2023

Individual Participant Data (IPD) Sharing Statement:

Plan to Share IPD:

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Additional relevant MeSH terms:

Parkinson Disease

Study Results

No Results Posted as of Jun 18, 2023