Afatinib, Paclitaxel, 2nd Line, Advanced Gastric Cancer

• Sponsor: Yonsei University (Other)
• Overall Status: Active, not recruiting
• CT.gov ID: NCT02501603
• Collaborator: (none)
• Enrollment: 72
• Location: 1
• Arm: 1
• Duration (Months): 77
• Patients Per Site Per Month: 0.9

Study Details

Study Description

Brief Summary

For the gastric cancer, paclitaxel is recommended as salvage standard treatment. Afatinib is a novel, potent, small ErbB family blocker that covalently binds and irreversibly blocks signaling through activated EGFR, HER2 and ErbB4 receptors, as well as the transphosphorylation of ErbB3. The investigators suggest a randomized phase II trial of afatinib plus weekly taxol(paclitaxel) for previously treated EGFR positive gastric cancer patients. The aim of current trial is to evaluate the antitumor efficacy of afatinib for target enriched patients in gastric cancer.

Condition or Disease	Intervention/Treatment	Phase
Gastric Cancer; Gastroesophageal Junction Cancer	Drug: afatinib; Drug: paclitaxel	Phase 2

Study Design

• Study Type: Interventional
• Anticipated Enrollment: 72 participants
• Allocation: N/A
• Intervention Model: Single Group Assignment
• Masking: None (Open Label)
• Primary Purpose: Treatment
• Official Title: An Open-label, Multicenter Phase II Study of Afatinib Plus Weekly Taxol as Second Line Treatment for Advanced/Recurrent Gastric and Gastroesophageal Junction Cancer
• Study Start Date: Jul 1, 2016
• Anticipated Primary Completion Date: Dec 1, 2021
• Anticipated Study Completion Date: Dec 1, 2022

Arms and Interventions

Arm	Intervention/Treatment
Experimental: afatinib plus paclitaxel afatinib plus paclitaxel	Drug: afatinib; Afatinib 40mg daily oral administration; Drug: paclitaxel; Paclitaxel 80mg/m2 IV weekly (day 1,8,15)

Outcome Measures

Primary Outcome Measures

1. compare progression free survival as measured by RECIST 1.1 [Every 6 weeks until progression, an expected average of 10 months]

   To identify antitumor activity of afatinib plus weekly taxol(paclitaxel) and explore predictive biomarker

Secondary Outcome Measures

1. antitumor efficacy as measured by RECIST 1.1 [every 6 weeks until progression, an expected average of 10 months]

2. safety as measured by CTCAE [every 3 weeks until progression, an expected average of 10 months]

Eligibility Criteria

Criteria

• Ages Eligible for Study: 19 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

1. Histologically or cytologically confirmed locally advanced or metastatic gastric cancer and gastroesophageal junction cancer

2. EGFR 2+ or 3+ expression (immunohistochemistry)

3. ECOG performance status of 0 to 1

4. Male or female; ≥ 19 years of age

5. Documented disease progression after one prior therapy, in locally advanced or metastatic setting

6. patients received last adjuvant chemotherapy less than six months can be enrolled into this study

7. Her2 positive patients must be progressed after prior trastuzumab based chemotherapy

8. Subjects with measurable lesion (using RECIST 1.1 criteria)

9. Subjects who meet the following criteria:

• Absolute neutrophil count (ANC) ≥ 1000 /µL (*ANC = Neutrophil segs ＋ Neutrophil bands)

• Platelet count ≥ 80,000/ µL

• Serum creatinine < 1.5 x upper limit of normal (ULN) or Creatinine clearance ≥50 mL/min using Cockcroft, Gault method

• AST (SGOT) and ALT (SGPT) : 3 x upper limit of normal (ULN) (If there is Liver Metastasis : 5 x upper limit of normal (ULN))

• Total bilirubin : 1.5 x upper limit of normal (ULN)

1. Provision of written informed consent prior to any study procedure

Exclusion Criteria:

1. Any unresolved chronic toxicity greater than CTC grade 2 from previous anticancer therapy.

2. Any previous chemotherapy or immunotherapy within 2 weeks

3. Any major operation or irradiation within 4 weeks of baseline disease assessment

4. Two or more previous systemic cytotoxic chemotherapy (adjuvant chemotherapy is not counted)

5. Any clinically significant gastrointestinal abnormalities which may impair intake or absorption of the study drug

6. Previously taxol(paclitaxel)-exposed patients

7. Subjects with symptomatic central nervous system (CNS) metastases who are neurologically unstable or have required increasing doses of steroids within the 2 weeks prior to study entry to manage CNS symptoms

8. Other co-existing malignancies or malignancies diagnosed within the last 3 years with the exception of basal cell carcinoma, thyroid cancer or cervical cancer in situ.

9. Subjects with an uncontrolled major cardiovascular disease (including AMI within 12 months, unstable angina within 6 months, over NYHA class III congestive heart failure, congenital long QT syndrome, 2° or more AV Block and uncontrolled hypertension)

10. Pregnant or lactating female

11. Patients with contraindicated medication

12. History of interstitial lung disease (ILD) or presence of ILD on chest X-ray

13. Evidence of any other significant clinical disorder or laboratory finding that makes it undesirable for the patient to participate in the study

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Severance Hospital, Yonsei University Health System, Yonsei Cancer Center	Seoul		Korea, Republic of	120-752

Sponsors and Collaborators

• Yonsei University

Investigators

• Principal Investigator: Sun Young Rha, Severance Hospital, Yonsei University Health System, Yonsei Cancer Center

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Sun Young Rha, Professor, Yonsei University
• ClinicalTrials.gov Identifier: NCT02501603
• Other Study ID Numbers: 4-2015-0244
• First Posted: Jul 17, 2015
• Last Update Posted: Apr 22, 2021
• Last Verified: Apr 1, 2021

• Additional relevant MeSH terms: Stomach Neoplasms; Paclitaxel; Afatinib

Study Results

No Results Posted as of Apr 22, 2021