Gastric Cancer Prevention for Indigenous Peoples
Study Details
Study Description
Brief Summary
The incidence of gastric cancer in local indigenous peoples is higher than the non-Indigenous counterpart in Taiwan. How to design an effective prevention strategy for gastric cancer is of importance. The present study aimed to identify the causes that may account for the health inequalities, allowing generation of a plan of action on the whole population scale.
Condition or Disease | Intervention/Treatment | Phase |
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N/A |
Detailed Description
Owing to the continuing gap in cancer burden between Indigenous and non-Indigenous peoples, reducing health disparities has drawn worldwide attention. Evidence indicates that the gastric cancer incidence and mortality rates in Indigenous peoples are much higher than those of non-Indigenous counterparts living in the same areas. Exposure to more risk factors from social habits, lifestyle, and Helicobacter pylori infection has been considered the cause. However, even though gastric cancer has been repeatedly shown to be preventable by eliminating risk factors, eradication policies are rarely designed for Indigenous peoples. Possible obstacles may include the lack of Indigenous health statistics, inadequate access to care, difficulty in modifying social habits and lifestyles, and the presence of environmental and cultural barriers. Developing and implementing a preventive strategy following the evidence-based principle remains a challenge.
In Taiwan, the number of Indigenous peoples has grown; however, their life expectancy remains substantially lower than that of the non-Indigenous population. Cancer is the most prevalent cause of death for Indigenous peoples and a disproportionate prevalence of certain kinds of cancer is noted for Indigenous peoples. These observations provide an opportunity to establish a plan of action, in which a specific intervention is developed to decrease the threat from each specific cancer so that the overall disparate burden can be reduced in a stepwise manner.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Other: Gastric cancer prevention 13C-urea breath test and anti-H. pylori treatment for those who are tested positive. |
Other: Gastric cancer prevention
Participants will receive the 13C-urea breath test and those with test positive will further receive H. pylori eradication treatment.
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Outcome Measures
Primary Outcome Measures
- Gastric cancer incidence [After at least 5 years, the gastric cancer incidence per 100,000 person-years is calculated by the person-years of follow-up.]
To assess the effect of H. pylori eradication for gastric cancer prevention
- Helicobacter eradication rate [At least 5 years]
To assess the eradication rate of anti-H. pylori treatment.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Aged 20-60 years
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Mentally competent to be able to understand the consent form
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Able to communicate with study staff for individuals
Exclusion Criteria:
- Pregnancy
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | National Taiwan University Hospital | Taipei City | Taiwan | 10002 |
Sponsors and Collaborators
- National Taiwan University Hospital
- Ministry of Health and Welfare, Taiwan
Investigators
- Principal Investigator: Yi-Chia Lee, MD, PhD, National Taiwan University Hospital
Study Documents (Full-Text)
None provided.More Information
Additional Information:
Publications
None provided.- 201804108RINB
- 1070056368