Treatment of Newly Diagnosed Gastroesophageal Reflux Disease in a National Population-based Cohort

Sponsor

University of Southern Denmark (Other)

Overall Status

Completed

CT.gov ID

NCT03524781

Collaborator

Kolding Sygehus (Other), Odense Patient Data Explorative Network (Other)

36,292

Enrollment

Location

Actual Duration (Months)

1343.8

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This study evaluates the treatment of newly diagnosed gastro-esophageal reflux disease in a Danish national cohort, comparing medical and surgical treatment.

Condition or Disease	Intervention/Treatment	Phase
Gastroesophageal Reflux

Detailed Description

Aim: To compare rate of surgery with medical treatment in patients with newly diagnosed gastro-esophageal reflux disease in a nationwide population based cohort over 15 years.

Background: Between 1990 and 1997, frequency of anti-reflux surgery in USA rose from 4,4 per 100.000 inhabitants to 12 per 100.000 inhabitants. In the same period a trans-abdominal laparoscopic approach increased to 64% of cases and mortality as well as morbidity decreased. The operation rate peaked around 2000 with an increase of 260% to approximately 16.7 operations per 100.000 inhabitants. Complications fell to its lowest point around 2000 as well.

Hereafter, the frequency of anti-reflux surgery dropped by 40% between 2000 and 2006. Complications in the form of morbidity and mortality rates steadily rose again, but the patients having performed surgery were now older and have longer hospital stays and more comorbidity. A slight rise in frequency of anti-reflux surgery to 6,1 per 100.000 inhabitants was registered in 2010 and at this time length of stay, morbidity and mortality rates have decreased, probably illustrating an increased experience. Interesting to note is, that in the American data, use of laparoscopic approach does tend to plateau at 70-80%.

It is unknown whether anti-reflux surgery in Denmark has followed the same trend. There are important differences in the setup of surgical service that may affect the results, as open anti-reflux surgery never gained much popularity in Denmark. Also, significantly fewer centers offer the procedure. In a study of re-operative anti-reflux surgery based on data from 1997-2005, a primary anti-reflux surgery rate of 5.2 per 100.000 inhabitants was reported. However, we do not know how this rate has developed or was preceded.

Hypothesis: From 2000-2015 there has been an increase in diagnosis of GERD and in the use of anti-secretory drugs, but a decrease in the utilization of anti-reflux surgery.

Methods and materials: Patient selection will be done through the Danish National Patient Registers. Included will be the period 2000-2015 for a total of 15 years of follow-up.

All adult Danish patients diagnosed with GERD and GERD-related diagnosis will be identified (ICD-10 DK21.0-21.9B & DK20.9B) using The National Patient Registry.To validate GERD-diagnosis, upper endoscopy must have been performed no more than three months before time of diagnosis.

Patients with GERD-diagnosis within previous four years or with concomitant diagnosis requiring independent anti-secretory treatment will be excluded (DK25.0-9, DK26.0-9, DK27.0-9, DK22.7 & DE16.4B). Patients diagnosed with cancer of the gastrointestinal tract (DC15-26) will also be excluded.

Using the Danish National Prescription Register, use of H2-antagonists (A02BA), proton pump inhibitors (A02BC), prostaglandins A02BB and bismuth, alginate and sucralfate (A02BX) will be identified in daily doses within two years of GERD-diagnosis. Anti-reflux surgery within the same period will be identified from The National Patient Registry using the procedure codes (NOMESCO: KJBC00, KJBC01, KJBC02, KJBW96, KJBW97).

From The National Patient Registry, age, sex and Charlson Comorbidity Index will be retrieved. Mortality during follow-up will be retrieved from The Civil Registration System.

Study Design

Study Type:

Observational [Patient Registry]

Actual Enrollment :

36292 participants

Observational Model:

Cohort

Time Perspective:

Prospective

Official Title:

Treatment of Newly Diagnosed Gastroesophageal Reflux Disease in a National Population-based Cohort

Actual Study Start Date :

May 2, 2018

Actual Primary Completion Date :

Jan 1, 2019

Actual Study Completion Date :

Aug 1, 2020

Outcome Measures

Primary Outcome Measures

Treatment of GERD [2 years after diagnosis]
Medical treatment, surgical treatment or no treatment

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Danish adult patient with GERD-diagnosis verified by upper endoscopy 1997-2014

Exclusion Criteria:

Any diagnosis of cancer in the gastrointestinal tract during follow-up
Patients with GERD-diagnosis within previous four years or with concomitant diagnosis requiring independent anti-secretory treatment will be excluded (DK25.0-9, DK26.0-9, DK27.0-9, DK22.7 & DE16.4B).