Gastrointestinal Evaluation in Young Men With Iron Deficiency Anemia

Sponsor

Assaf-Harofeh Medical Center (Other)

Overall Status

Unknown status

CT.gov ID

NCT00498511

Collaborator

(none)

Location

Study Details

Study Description

Brief Summary

Both upper gastrointestinal endoscopy and colonoscopy are recommended in men and post-menopausal women with iron deficiency anemia. Due to lack of data on the yield of these endoscopies in young men, they are currently investigated as older men. The aim of this study is to evaluate prospectively the prevalence of various gastrointestinal lesions in young men with iron deficiency anemia. Our hypothesis is that the diagnostic yield of colonoscopy in young anemic men without gastrointestinal symptoms is very low, especially if a potential lesion is detected during upper gastrointestinal endoscopy. Therefore, this study will try to identify predicting factors regarding the yield of both endoscopies. Another purpose is to evaluate the outcome of patients with negative endoscopic results, during a follow-up of two years.

Condition or Disease	Intervention/Treatment	Phase
Anemia, Iron-Deficiency	Procedure: upper gastrointestinal endoscopy, colonoscopy

Study Design

Study Type:

Observational

Observational Model:

Defined Population

Time Perspective:

Prospective

Official Title:

Prospective Evaluation of the Gastrointestinal Tract in Young Men With Iron Deficiency Anemia

Study Start Date :

Aug 1, 2007

Outcome Measures

Primary Outcome Measures

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 40 Years

Sexes Eligible for Study:

Male

Accepts Healthy Volunteers:

Inclusion Criteria:

Men < 40 years old of age with iron deficiency.
hemoglobin level less than 13 gr/dl documented during the 2 years prior to entering the study with one of the following: 1) iron level less than 45 μg /dl and transferrin saturation less than 10%; 2) ferritin level less than 20 μg/L (both documented during the 4 months prior to entering the study).

Exclusion Criteria:

Previously diagnosed disease that explain iron deficiency anemia
Colonoscopy performed during the last 4 years
Upper gastrointestinal endoscopy performed during the last 2 years

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Institute of Gastroenterology and Liver Diseases, Assaf harofeh Medical Center	Zerifin		Israel	70300

Sponsors and Collaborators

Assaf-Harofeh Medical Center

Investigators

Principal Investigator: Alain Nimrod Kimchi, M.D., Institute of Gastroenterology and Liver Diseases, Assaf-Harofeh Medical Center, 70300 Zerifin, Israel