Investigation of the Perceptual and Acoustic Voice in Trans Man
Study Details
Study Description
Brief Summary
The aim of the study is to follow acoustic and perceptual voice changes in trans men during hormone therapy and to examine the relationship between psychosocial and vocal characteristics and testosterone measured in routine follow-up in accordance with international follow-up guidelines.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Trans men who have completed the evaluation and follow-up procedure and decided to use sex hormones will be included in the study. Participants will be followed for 6 months with three-month-follow ups. Acoustic and perceptual changes in voice will be monitored during hormone therapy. The relationship between testosterone and psychosocial and vocal characteristics will be examined. At the baseline of the study, participants will be evaluated with Videolaryngostroboscopy (VLS). As a result of VLS, perceptual and acoustic voice evaluation will be made to the participants who are determined to have healthy vocal folds. During routine psychiatric visits, participants will be asked to fill in self-report scales. Endocrinological routine evaluations will be applied to the participants and the data of these routine evaluations will be used in the study. All of these evaluations (perceptual and acoustic voice evaluation, endocrinological and psychiatric evaluations) will be repeated at the 3rd and 6th months of the hormone therapy, except for the VLS evaluation.
IBM SPSS Statistics 26.0 and Microsoft Excel 365 programs will be used for statistical analysis. The number of participants to be included in the study was calculated using the G Power 3.1 program. In the analysis, the number of participants was determined as 28 (G power=0.80, α =0.05). The normal distribution of the data will be examined by visual and analytical methods (Shapiro-Wilk test, Kolmogorov-Smirnov test).The analysis of each variable measured at three time points will be evaluated using ANOVA if the assumptions of parametric tests are met, and using the Friedman test if the assumptions of parametric tests are not met. When the parametric conditions are met Paired t test will be used to compare the measurement values, and when the parametric conditions are not met, the Wilcoxon signed-rank test will be used. Multiple Regression Analysis will be used to determine the factors affecting the person's own perception of voince. Finally, statistical significance level was accepted as p<0.05.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Trans man "Trans man" is assigned female at birth and identify as man |
Other: Testosterone Hormon Therapy
Testosterone isocaproate, ... ml, once per 21 days for 6 months period.
|
Outcome Measures
Primary Outcome Measures
- Change in Self-perception of voice [change from baseline to 3rd month]
Transsexual Voice Questionnaire (TVQ-Female to male) Score Self-perception of voice masculinity (SPVM) Score
- Change in Self-perception of voice [change from baseline to 6rd month]
Transsexual Voice Questionnaire (TVQ-Female to male) Score Self-perception of voice masculinity (SPVM) Score
- Change in Self-perception of voice [change from 3rd months to 6th months]
Transsexual Voice Questionnaire (TVQ-Female to male) Score Self-perception of voice masculinity (SPVM) Score
Secondary Outcome Measures
- Change in Acoustic Voice Characteristics [change from baseline to 3rd month]
Digital recordings will be made using the Computerized Speech Lab (KayPENTAX) while performing the following tasks: sustained vowel /a:/, sponteous speech and "Pinokyo passage" reading. Voice recordings will be analyzed using the Real-Time Pitch Program and the Multidimensional Voice Program for measure F0, Mean F0, Jitter percent, Shimmer Percent, and noise-to-harmonic ratio (NHR).
- Change in Acoustic Voice Characteristics [change from baseline to 6rd month]
Digital recordings will be made using the Computerized Speech Lab (KayPENTAX) while performing the following tasks: sustained vowel /a:/, sponteous speech and "Pinokyo passage" reading. Voice recordings will be analyzed using the Real-Time Pitch Program and the Multidimensional Voice Program for measure F0, Mean F0, Jitter percent, Shimmer Percent, and noise-to-harmonic ratio (NHR).
- Change in Acoustic Voice Characteristics [change from 3rd months to 6th months]
Digital recordings will be made using the Computerized Speech Lab (KayPENTAX) while performing the following tasks: sustained vowel /a:/, sponteous speech and "Pinokyo passage" reading. Voice recordings will be analyzed using the Real-Time Pitch Program and the Multidimensional Voice Program for measure F0, Mean F0, Jitter percent, Shimmer Percent, and noise-to-harmonic ratio (NHR).
- Changes in the person's severity of depression [change from baseline to 3rd month]
- Beck depression inventory (BDI)
- Changes in the person's severity of depression [change from baseline to 6rd month]
- Beck depression inventory (BDI)
- Changes in the person's severity of depression [change from 3rd months to 6th months]
- Beck depression inventory (BDI)
- Changes in the person's perception of support [change from baseline to 3rd month]
- Multidimensional Scale of Perceived Social Support.
- Changes in the person's perception of support [change from baseline to 6rd month]
- Multidimensional Scale of Perceived Social Support.
- Changes in the person's perception of support [change from 3rd months to 6th months]
- Multidimensional Scale of Perceived Social Support.
- Changes in the person's anxiety level [change from baseline to 3rd month]
- State-trait anxiety Inventory
- Changes in the person's anxiety level [change from baseline to 6rd month]
- State-trait anxiety Inventory
- Changes in the person's anxiety level [change from 3rd months to 6th months]
- State-trait anxiety Inventory
- Changes in the person's gender perception and gender transition process [change from baseline to 3rd month]
- Transition questionnaire: The Transition Questionnaire is a self-report instrument that collects information on an individual's self-perception of status about the social and medical steps in the process of gender transition.
- Changes in the person's gender perception and gender transition process [change from baseline to 6rd month]
- Transition questionnaire: The Transition Questionnaire is a self-report instrument that collects information on an individual's self-perception of status about the social and medical steps in the process of gender transition.
- Changes in the person's gender perception and gender transition process [change from 3rd months to 6th months]
- Transition questionnaire: The Transition Questionnaire is a self-report instrument that collects information on an individual's self-perception of status about the social and medical steps in the process of gender transition.
- Changes in the person's body image perception [change from baseline to 3rd month]
-Body cathexis scale
- Changes in the person's body image perception [change from baseline to 6rd month]
-Body cathexis scale
- Changes in the person's body image perception [change from 3rd months to 6th months]
-Body cathexis scale
- Change in testosterone level [change from baseline to 3rd month]
Testosterone level measurement
- Change in testosterone level [change from baseline to 6rd month]
Testosterone level measurement
- Change in testosterone level [change from 3rd months to 6th months]
Testosterone level measurement
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Being diagnosed with "Gender Dysphoria" according to DSM 5
-
Having decided to start hormone therapy
Exclusion Criteria:
-
Diagnosis of vocal fold lesion in videolaryngostroboscopy evaluation
-
Having previously received voice therapy or undergone voice surgery
-
Having a systematic/or neurological disorder that may affect voice quality
-
Having had hormone therapy or still on hormone therapy
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Hacettepe University, Speech and Language Therapy | Ankara | Turkey |
Sponsors and Collaborators
- Hacettepe University
Investigators
- Study Director: Fatma Esen AYDINLI, Assoc. Prof., Hacettepe University, Speech and Language Therapy Departmant
- Study Chair: Merve OGULMUS, SLP., Hacettepe University, Speech and Language Therapy
- Study Chair: Koray Baser, Assoc. Prof., Hacettepe Univeristy, Faculty of Medicine, Mental Health and Disease Department
- Study Chair: Bulent Okan YILDIZ, Prof., Hacettepe University, Faculty of Medicine, Endocrinology department
- Study Chair: Taner YILMAZ, Prof., Hacettepe University, Faculty of Medicine, Otorhinolaryngology department
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- HUSLPTRANSMANVOICE