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Gene Expression in Patients With Epiretinal Membranes

Sponsor
Medical University of Silesia (Other)
Overall Status
Unknown status
CT.gov ID
NCT01946451
Collaborator
(none)
1
Location
18
Duration (Months)

Study Details

Study Description

Brief Summary

The purpose of this study was to investigate the expression of selected genes both in epiretinal membranes (ERMs) and peripheral blood mononuclear cells (PBMCs) from patients with primary and secondary epiretinal membranes in proliferative diabetic retinopathy. Possible correlations between messenger ribonucleic acid (mRNA) levels of these genes were also identified.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Observational Model:
    Case-Control
    Time Perspective:
    Retrospective
    Official Title:
    Gene Expression and Their Correlations in Patients With Idiopathic and Secondary Epiretinal Membranes in Proliferative Diabetic Retinopathy
    Study Start Date :
    Jun 1, 2012
    Actual Primary Completion Date :
    Sep 1, 2013
    Anticipated Study Completion Date :
    Dec 1, 2013

    Arms and Interventions

    Arm Intervention/Treatment
    Idiophatic ERMs
    Secondary ERMs

    Outcome Measures

    Primary Outcome Measures

    1. Gene expression in patients with idiopathic and secondary epiretinal membranes in proliferative diabetic retinopathy. [The period between the diagnosis of the ERMs and the actual surgery for the condition was between 2 and 43 months.]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    55 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • Caucasian race,

    • both males and females,

    • aged ≥ 55 years,

    • suffering from idiopathic ERMs or secondary ERMs in proliferative diabetic retinopathy (PDR).

    • Presence of ERM was proven in optical coherence tomography (OCT) examination.

    Exclusion criteria:

    • aged < 55 years,

    • systemic connective tissue disease,

    • active inflammatory process

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Medical University of Silesia Katowice Poland

    Sponsors and Collaborators

    • Medical University of Silesia

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Dorota Romaniuk, MD, Medical University of Silesia
    ClinicalTrials.gov Identifier:
    NCT01946451
    Other Study ID Numbers:
    • SilesianMU
    First Posted:
    Sep 19, 2013
    Last Update Posted:
    Sep 19, 2013
    Last Verified:
    Sep 1, 2013
    Keywords provided by Dorota Romaniuk, MD, Medical University of Silesia
    idiopathic epiretinal membranes
    secondary epiretinal membranes
    Additional relevant MeSH terms:
    Retinal Diseases
    Diabetic Retinopathy
    Epiretinal Membrane

    Study Results

    No Results Posted as of Sep 19, 2013