Gene Expression Profiling in Subjects With Postoperative Atrial Fibrillation After Cardiac Surgery (GENEXPRO Surg)

• Sponsor: Brigham and Women's Hospital (Other)
• Overall Status: Recruiting
• CT.gov ID: NCT00833313
• Collaborator: (none)
• Enrollment: 350
• Location: 1
• Anticipated Duration (Months): 204
• Patients Per Site Per Month: 1.7

Study Details

Study Description

Brief Summary

Atrial fibrillation is a type of irregular heartbeat that is common after having heart surgery. There may be many different reasons why some people get atrial fibrillation after their heart surgery. These reasons may include that a person is older or that he/she is taking certain types of medications before surgery. Genes may also be a reason. Genes contain the material passed from parent to child that determines the make-up of the body and mind. For example, some genes control the color of your hair or eyes. Some people may have genes that make it more likely for them to get atrial fibrillation after their heart surgery. This research project is being done to find out if the cells of people who develop atrial fibrillation after heart surgery are different from the cells in people who do not develop atrial fibrillation after surgery.

Condition or Disease	Intervention/Treatment	Phase
Atrial Fibrillation	Procedure: Atrial biopsy

Detailed Description

Atrial fibrillation is a type of irregular heartbeat that is common after having heart surgery. There may be many different reasons why some people get atrial fibrillation after their heart surgery. These reasons may include that a person is older or that he/she is taking certain types of medications before surgery. Genes may also be a reason. Genes contain the material passed from parent to child that determines the make-up of the body and mind. For example, some genes control the color of your hair or eyes. Some people may have genes that make it more likely for them to get atrial fibrillation after their heart surgery. This research project is being done to find out if the cells of people who develop atrial fibrillation after heart surgery are different from the cells in people who do not develop atrial fibrillation after surgery.

This study seeks to identify regulatory events in atrial myocyte transcription and translation that are altered by germline variation

Study Design

• Study Type: Observational
• Anticipated Enrollment: 350 participants
• Observational Model: Cohort
• Time Perspective: Prospective
• Official Title: Gene Expression Profiling in Subjects With Postoperative Atrial Fibrillation After Cardiac Surgery (GENEXPRO Surg)
• Actual Study Start Date: Aug 1, 2008
• Anticipated Primary Completion Date: Aug 1, 2025
• Anticipated Study Completion Date: Aug 1, 2025

Outcome Measures

Primary Outcome Measures

1. Gene expression [Immediate]

Eligibility Criteria

Criteria

• Ages Eligible for Study: 20 Years to 99 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• Age 20-99 years

• Undergoing cardiac surgery

Exclusion Criteria:

• Prior cardiac surgery

• chest radiation

• recent chemotherapy

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Brigham and Women's Hospital	Boston	Massachusetts	United States	02115

Sponsors and Collaborators

• Brigham and Women's Hospital

Investigators

• Principal Investigator: Jochen D Muehlschlegel, MD, Brigham and Women's Hospital

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Jochen Daniel Muehlschlegel, MD, Associate Professor, Brigham and Women's Hospital
• ClinicalTrials.gov Identifier: NCT00833313
• Other Study ID Numbers: 2008-P000896
• First Posted: Feb 2, 2009
• Last Update Posted: May 11, 2021
• Last Verified: May 1, 2021

• Keywords provided by Jochen Daniel Muehlschlegel, MD, Associate Professor, Brigham and Women's Hospital: Atrial fibrillation; Gene expression; Genetic
• Additional relevant MeSH terms: Atrial Fibrillation

Study Results

No Results Posted as of May 11, 2021