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A Gene Hunting Study for Familial Papillary Thyroid Cancer

Sponsor
Ohio State University Comprehensive Cancer Center (Other)
Overall Status
Unknown status
CT.gov ID
NCT02776969
Collaborator
(none)
1,200
Enrollment
1
Location
281
Duration (Months)
4.3
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The aim of this project is to identify genetic risk factors associated with familial papillary thyroid carcinoma (PTC). Papillary thyroid cancer is a type of cancer that shows high heritability. However, the specific genetic factors that cause an increased risk have been elusive.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    The aim of this project is to identify genetic risk factors associated with familial papillary thyroid carcinoma (PTC). This can be accomplished in several ways, including loss of heterozygosity studies as well as comparative gene expression analysis. When possible, linkage analysis on families with multiple individuals affected with PTC may also help identify the putative gene(s).

    Study participants will be asked to:

    1. Complete family history and medical history questionnaires

    2. Sign a medical record release so that thyroid cancer pathology reports can be obtained

    3. Supply a blood sample for genetic studies

    4. Provide study related information to family members who are needed for family studies

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    1200 participants
    Observational Model:
    Cohort
    Time Perspective:
    Prospective
    Official Title:
    A Strategy to Search for Genes Predisposing to Papillary Carcinoma of the Thyroid When Mutated
    Study Start Date :
    Jul 1, 1998
    Anticipated Primary Completion Date :
    Dec 1, 2021
    Anticipated Study Completion Date :
    Dec 1, 2021

    Outcome Measures

    Primary Outcome Measures

    1. Genetic variants associated with familial papillary thyroid cancer as assessed by multiple genetic testing methodologies [Up to 5 years]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Eligibility Criteria:

    • Patients with a diagnosis of PTC and a family history of PTC in 3 or more living relatives

    • Affected and unaffected family members of the proband*

    • For familial cases (families with 4 or more cases of PTC), participation will be offered to all living family members with PTC or benign thyroid disease as well as selected unaffected first and second degree relatives. Participation may also be offered to spouses when needed for analyzing parent/offspring samples.

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Ohio State University Columbus Ohio United States 43210

    Sponsors and Collaborators

    • Ohio State University Comprehensive Cancer Center

    Investigators

    • Principal Investigator: Albert de la Chapelle, MD, Ohio State University Comprehensive Cancer Center

    Study Documents (Full-Text)

    None provided.

    More Information

    Additional Information:

    Publications

    None provided.
    Responsible Party:
    Albert De la Chapelle, Principal Investigator, Ohio State University Comprehensive Cancer Center
    ClinicalTrials.gov Identifier:
    NCT02776969
    Other Study ID Numbers:
    • OSU-9812
    First Posted:
    May 19, 2016
    Last Update Posted:
    Mar 5, 2020
    Last Verified:
    Mar 1, 2020
    Individual Participant Data (IPD) Sharing Statement:
    No
    Plan to Share IPD:
    No
    Keywords provided by Albert De la Chapelle, Principal Investigator, Ohio State University Comprehensive Cancer Center
    Papillary Carcinoma
    Gene Hunting
    Familial
    Additional relevant MeSH terms:
    Thyroid Diseases

    Study Results

    No Results Posted as of Mar 5, 2020