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Genetic Basis of Rosacea

Sponsor
Stanford University (Other)
Overall Status
Completed
CT.gov ID
NCT02787616
Collaborator
(none)
306
Enrollment
1
Location
79.1
Actual Duration (Months)
3.9
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Rosacea is a common disease characterized by inflammation and vascular abnormalities of the facial skin and ocular surface. The exact pathogenesis of papulopustular rosacea is not well understood and current methods to treat this disease are often unsatisfactory. The purpose of this study is to develop gene expression profiles of papulopustular rosacea compared to those of normal skin. The investigators hope to better understand the abnormal gene functions that might contribute to this condition. This understanding may lead to the development of additional and better treatments for rosacea.

Condition or Disease Intervention/Treatment Phase
  • Genetic: buccal swab

Study Design

Study Type:
Observational
Actual Enrollment :
306 participants
Observational Model:
Cohort
Time Perspective:
Prospective
Official Title:
Validation of Candidate Rosacea Genes By Targeted Interrogation of Alleles and Assessment of Rosacea Co-morbidities
Actual Study Start Date :
Apr 13, 2012
Actual Primary Completion Date :
Nov 16, 2018
Actual Study Completion Date :
Nov 16, 2018

Arms and Interventions

Arm Intervention/Treatment
Rosacea Group

Genetic: buccal swab
cheek swab for DNA sampling
Non-Rosacea Group

Genetic: buccal swab
cheek swab for DNA sampling

Outcome Measures

Primary Outcome Measures

  1. Targeted interrogation of alleles and assessment of rosacea co-morbidities. [Up to 2 years]

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Eligibility Criteria for Rosacea Group:
Inclusion criteria for rosacea participants:

  1. Clinical signs and symptoms of rosacea (papulopustular or erythrotelangiectatic subtypes) present at enrollment as determined by the investigator

  2. All four grandparents of European descent

  3. Fitzpatrick skin type I or II

  4. Age 18 years or older

Exclusion criteria for rosacea participants:

  1. Unable or unwilling to provide written informed consent

  2. Concomitant facial or medical condition that obscures diagnosis of rosacea (such as malar erythema from lupus erythematosus)

  3. Acne vulgaris

  4. Unable or unwilling to provide peripheral blood sample (a few teaspoons)

  5. Inability for investigator to verify rosacea diagnosis on clinical examination due to rosacea treatment(s) leading to complete lack of signs and symptoms (such prior laser treatments, systemic tetracycline usage, etc.)

  6. Use of topical prescription medications or procedures to the face within one month of enrollment

  7. Women who are pregnant or lactating

Eligibility Criteria for Non-Rosacea Group:
Inclusion criteria for control participants:

  1. No history of rosacea

  2. No clinical signs or symptoms of rosacea

  3. No family history of rosacea

  4. All four grandparents of European descent

  5. Fitzpatrick skin type I or II

  6. Age 18 years or older

Exclusion criteria for control participants:

  1. Unable or unwilling to provide written informed consent

  2. Acne vulgaris

  3. Unable or unwilling to provide peripheral blood sample (a few teaspoons)

  4. Women who are pregnant or lactating

  5. Use of topical prescription medications or procedures to the face within one month of enrollment

  6. Skin conditions that might interfere with interpretation of procedure results (at the discretion of the investigator)

Contacts and Locations

Locations

Site City State Country Postal Code
1 Stanford Dermatology Redwood City California United States 94603

Sponsors and Collaborators

  • Stanford University

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Anne Chang, Associate Professor of Dermatology, Stanford University
ClinicalTrials.gov Identifier:
NCT02787616
Other Study ID Numbers:
  • R15006
First Posted:
Jun 1, 2016
Last Update Posted:
Sep 26, 2019
Last Verified:
Sep 1, 2019
Additional relevant MeSH terms:
Rosacea

Study Results

No Results Posted as of Sep 26, 2019