Genetic Characterization of Parkinson's Disease

Sponsor
National Institute of Neurological Disorders and Stroke (NINDS) (NIH)
Overall Status
Completed
CT.gov ID
NCT00105131
Collaborator
(none)
2,500
1
8
310.6

Study Details

Study Description

Brief Summary

This study will explore the risks and causes of Parkinson's disease, a chronic progressive nervous system disorder. Patients typically have tremors, muscle weakness and a shuffling gait.

Patients with Parkinson's disease, their relatives and healthy volunteers may be eligible for this study. Candidates must be 18 years of age or older. Patients whose parkinsonism is due to a secondary cause, such as infection or injury, and healthy volunteers who have a first degree family member (parent, grandparent, child, sibling) with Parkinson's disease are excluded from enrollment.

Participants are asked about possible symptoms they may have and about their general health. They provide a blood sample to obtain DNA for genetic analysis to look for genetic differences that might be related to risks for Parkinson's disease. White blood cells may be treated in the laboratory to grow a cell line, which provides a source of substances in the blood without having to draw samples repeatedly.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Parkinson's disease (PD) was noted to have a familial component as early as 1880. More recently, the discovery of several genetic factors influencing Parkinson's disease has emphasized the importance of heredity in PD.

    Objective: The goal of this protocol will be to contribute to the genetic understanding of Parkinson's disease. Clinical data will be collected in order to document the features of Parkinson's disease in affected individuals (phenotyping). Genetic characterization will be undertaken for the discovery of specific genes which cause or contribute to the risk for Parkinson's disease (genotyping).

    Design: The study design has two components. The first (aim 1) involves positional cloning for gene discovery in families with apparent Mendelian inheritance. The second (aim 2) will utilize an association study design, using genetic case-control methods for assessment of genetic risk factors. We will examine individuals affected by Parkinson's disease and their family members towards Specific Aim 1. Specific Aim 2 will involve evaluation of individuals with apparent sporadic Parkinson's disease, and also, healthy adult volunteers who will be recruited as control subjects.

    Outcome Measures:
    Primary Outcome Measures for Specific Aim 1 are:
    1. The identification of new genes causal for Parkinson's disease.

    2. The identification of new mutations in known genes.

    Primary Outcome Measures for Specific Aim 2 are:
    1. The discovery of gene variants which confer risk for Parkinson's disease.

    2. The validation of already reported polymorphisms as risk factors for PD.

    Secondary Outcome Measures (both Specific Aims 1 and 2): Genotype/phenotype correlations for specific genetic forms of Parkinson's disease. For example, we will assess if a particular age of onset, cardinal or secondary feature of PD or associated clinical course is associated with a given genotype.

    Future Direction: Because 1) the larger sample base the greater the likelihood of the discovery of genes of minor effect and 2) discoveries of genetic risk factors require validation in additional sample series, it is likely that renewal of this protocol will be sought after five years.

    Study Population: We aim to enroll a total of 2500 subjects over five years. These will include approximately 500 samples for the Mendelian studies (Specific Aim 1), and 2000 for association studies (Specific Aim 2). These estimates are based both on feasibility and on statistical power. Subjects will be evaluated at the NIH Clinical Center.

    Study Design

    Study Type:
    Observational
    Official Title:
    Genetic Characterization of Parkinson's Disease
    Study Start Date :
    Mar 1, 2005
    Study Completion Date :
    Nov 1, 2005

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      N/A and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      Yes
      INCLUSION CRITERIA:

      Individuals with Parkinson's disease OR

      Family members of an individual diagnosed with Parkinson's disease OR

      Healthy adult controls obtained through the NIH Clinical Research Volunteers Program (CVRP) or other healthy control volunteers who come forward.

      EXCLUSION CRITERIA:

      Under the age of 18 years of age OR

      Individuals with Parkinsonism secondary to a specific cause such as toxin exposure, birth injury, head injury, or brain infection such as encephalitis.

      Healthy volunteers with a medical history or first degree family history of Parkinson's disease.

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 National Institute of Neurological Disorders and Stroke (NINDS) Bethesda Maryland United States 20892

      Sponsors and Collaborators

      • National Institute of Neurological Disorders and Stroke (NINDS)

      Investigators

      None specified.

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      Responsible Party:
      , ,
      ClinicalTrials.gov Identifier:
      NCT00105131
      Other Study ID Numbers:
      • 050115
      • 05-N-0115
      First Posted:
      Mar 7, 2005
      Last Update Posted:
      Mar 4, 2008
      Last Verified:
      Nov 1, 2005

      Study Results

      No Results Posted as of Mar 4, 2008