Genetic Examination of Patients With Primary Multiple Hernia
Sponsor
Herlev Hospital (Other)
Overall Status
Unknown status
CT.gov ID
NCT00979095
Collaborator
(none)
60
1
30
2
Study Details
Study Description
Brief Summary
The investigators are performing a genetic study of patients with multiple hernias (at least 3 primary hernias) versus a healthy control group. This genetic information is compared with circulating and subcutaneously biomarkers such as matrix-metalloproteinases (MMP's).
The hypothesis is that patients with multiple hernias have different expression of specific genes compared to the healthy control group.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
|
Detailed Description
Other examinations performed on the patients enrolled in this study:
-
Ultrasound (US) examination of the abdominal aorta to discover possible abdominal aortic aneurysms.
-
Beightons score to evaluate the degree of joint hypermobility.
Study Design
Study Type:
Observational
Anticipated Enrollment
:
60 participants
Observational Model:
Case-Control
Time Perspective:
Prospective
Official Title:
Genetic Differences Between Patients With Multiple Hernia and a Healthy Control Group
Study Start Date
:
Jun 1, 2009
Anticipated Primary Completion Date
:
Jun 1, 2011
Anticipated Study Completion Date
:
Dec 1, 2011
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Multiple hernia Patients with more than 3 primary hernias |
|
| Control group Patients without hernias |
Outcome Measures
Primary Outcome Measures
- Genetic expression of relevant genes between the groups [12 months]
Secondary Outcome Measures
- Amount of serological biomarkers (MMP's) correlated to gene expression [12 months]
Eligibility Criteria
Criteria
Ages Eligible for Study:
18 Years
and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:
- Patients with minimum 3 primary hernias
Exclusion Criteria:
- Patients under 18 years
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Jacob Rosenberg | Herlev Hospital | Herev | Denmark | 2730 |
Sponsors and Collaborators
- Herlev Hospital
Investigators
- Study Director: Jacob Rosenberg, Prof. MD, Herlev Hospital
- Principal Investigator: Jakob Burcharth, MD, Herlev Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
,
,
ClinicalTrials.gov Identifier:
NCT00979095
Other Study ID Numbers:
- H-D-2008-126
First Posted:
Sep 17, 2009
Last Update Posted:
Oct 13, 2010
Last Verified:
Oct 1, 2010