Genetic Mutation in Epithelial Ovarian Cancer
Study Details
Study Description
Brief Summary
Little is known about the characteristics of genetic mutation in a large multi-gene panel in epithelial ovarian cancer. This study is to explore the targeted genetic mutations via a multi-gene panel, which consists of more than 500 hundred genes. The mutation characteristics are to be revealed in single nucleotide variants, copy number variations, insertion-deletion variations, and genomic structural variations. The total mutation burden (TMB) will be calculated. The status of microsatellite instability, expression of PD-1 and PD-L1 antibodies are also tested. These findings will be studies in association with the patients' prognosis and sensitivity to platinum-based chemotherapy.
Condition or Disease | Intervention/Treatment | Phase |
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Study Design
Outcome Measures
Primary Outcome Measures
- Frequency of genetic mutations [Two years]
Frequency of various genetic mutations among recruited patients
Secondary Outcome Measures
- Total mutation burden [Two years]
Total mutation burden calculated in definite patient
- Frequency of microsatellite Instability [Two years]
Microsatellite Instability in definite patient
- Expression rates of PD-1 and PD-L1 antibodies [Two years]
Expression rates of PD-1 and PD-L1 antibodies among recruited patients
Eligibility Criteria
Criteria
Inclusion Criteria:
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Aged 18 years or older
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Pathology confirmed of recurrent cervical adenocarcinoma, squamous carcinoma or adenosquamous carcinoma
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With available materials for analysis
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With detailed clinicopathological information
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Given consent to participate the trial
Exclusion Criteria:
- Not meeting all of the inclusion criteria
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Lei Li | Beijing | Beijing | China | 100730 |
Sponsors and Collaborators
- Lei Li
Investigators
- Principal Investigator: Lei Li, M.D., Peking Union Medical College Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- EOC-TMB