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GP: Genetic Polymorphisms in Idiopathic Pulmonary Fibrosis (IPF)

Sponsor
University of Pittsburgh (Other)
Overall Status
Recruiting
CT.gov ID
NCT00258570
Collaborator
(none)
2,000
Enrollment
1
Location
270
Duration (Months)
7.4
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purposes of this study are:

  • to determine if there are specific genetic traits that might explain why patients have developed pulmonary fibrosis;

  • to determine if specific genetic traits account for differing patterns of inflammation and scar tissue that has formed in the patient's lungs.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Idiopathic pulmonary fibrosis is one of a collection of severe lung diseases that lead to abnormal inflammation and scarring of the lungs. The accumulation of scar tissue in the lung destroys normal lung tissue and results in the symptoms associated with this disease. The cause of the disease is currently unknown. In this study, we are attempting to determine if there are specific genetic traits that might explain why patients have developed pulmonary fibrosis. We are also attempting to determine if specific genetic traits account for differing patterns of inflammation and scar tissue that has formed in the patient's lungs. The purpose of this research is to identify genes that control the processes of lung inflammation, lung scarring, and lung repair. As more information becomes available, we will also conduct studies of additional genes that are found to be involved in this disease process.

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    2000 participants
    Observational Model:
    Cohort
    Time Perspective:
    Other
    Official Title:
    Genetic Polymorphisms in Idiopathic Pulmonary Fibrosis
    Study Start Date :
    Jan 1, 2003
    Anticipated Primary Completion Date :
    Jul 1, 2025
    Anticipated Study Completion Date :
    Jul 1, 2025

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      18 Years and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      No
      Inclusion Criteria:

      • 18 years of age or older

      • Diagnosis of pulmonary fibrosis confirmed by physical examination, pulmonary function testing, chest X-ray, and computed tomography (CT) scans.

      • Adult patients who are seeking treatment at the Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease.

      Exclusion Criteria:

      • Under 18 years of age

      • Non-fibrotic ILD

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 University of Pittsburgh Pittsburgh Pennsylvania United States 15213

      Sponsors and Collaborators

      • University of Pittsburgh

      Investigators

      • Principal Investigator: Kevin F Gibson, MD, University of Pittsburgh, Simmons Center for ILD

      Study Documents (Full-Text)

      None provided.

      More Information

      Additional Information:

      Publications

      None provided.
      Responsible Party:
      Kevin F. Gibson, Professor of Medicine, University of Pittsburgh
      ClinicalTrials.gov Identifier:
      NCT00258570
      Other Study ID Numbers:
      • 020123
      First Posted:
      Nov 24, 2005
      Last Update Posted:
      Nov 3, 2021
      Last Verified:
      Nov 1, 2021
      Keywords provided by Kevin F. Gibson, Professor of Medicine, University of Pittsburgh
      "Lung[A04.400]"
      Additional relevant MeSH terms:
      Pulmonary Fibrosis
      Idiopathic Pulmonary Fibrosis
      Fibrosis

      Study Results

      No Results Posted as of Nov 3, 2021