Genetic Studies of Strabismus and Associated Disorders
Sponsor
Boston Children's Hospital (Other)
Overall Status
Recruiting
CT.gov ID
NCT04770519
Collaborator
(none)
100
1
62.9
1.6
Study Details
Study Description
Brief Summary
Strabismus (misalignment of the eyes) often runs in families. In this study, the investigators are looking for genetic variants in families in which multiple people have strabismus. Families with at least 3 members with strabismus will be enrolled, and whole genome sequencing will be used to identify genetic variants shared by family members with strabismus.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Study Type:
Observational
Anticipated Enrollment
:
100 participants
Observational Model:
Family-Based
Time Perspective:
Retrospective
Official Title:
Genetic Studies of Strabismus and Associated Disorders
Actual Study Start Date
:
Sep 3, 2021
Anticipated Primary Completion Date
:
Dec 1, 2026
Anticipated Study Completion Date
:
Dec 1, 2026
Outcome Measures
Primary Outcome Measures
- Genetic variants [2 years]
genetic variants shared by family members with strabismus
Eligibility Criteria
Criteria
Ages Eligible for Study:
N/A
and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria: Member of a family with at least 3 biological relatives with strabismus. (Both affected and non-affected family members will be enrolled).
-
Exclusion Criteria: paralytic strabismus in affected family members
-
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Boston Children's Hospital | Boston | Massachusetts | United States | 02115 |
Sponsors and Collaborators
- Boston Children's Hospital
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
Mary Whitman,
Assistant Professor of Ophthalmology,
Boston Children's Hospital
ClinicalTrials.gov Identifier:
NCT04770519
Other Study ID Numbers:
- IRB-P00036313
First Posted:
Feb 25, 2021
Last Update Posted:
Sep 5, 2021
Last Verified:
Sep 1, 2021
Individual Participant Data (IPD) Sharing Statement:
Yes
Plan to Share IPD:
Yes
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Keywords provided by Mary Whitman,
Assistant Professor of Ophthalmology,
Boston Children's Hospital
Additional relevant MeSH terms: