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Genetic Susceptibility to Radiation Induced Thyroid Cancer

Sponsor
Institut National de la Santé Et de la Recherche Médicale, France (Other)
Overall Status
Unknown status
CT.gov ID
NCT04139096
Collaborator
(none)
60
Enrollment
1
Location
7.3
Anticipated Duration (Months)
8.3
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Case control on thyroid cancer occuring in a cohort of 7300 subjects treated during their childhood, mostly by radiotherapy, for a skin Angioma at Gustave Roussy, Villejuif France between 1947 and 1973.

This case control study, which is included in a larger european project, aims to investigate the DNA variant interacting with the risk of radiation induced thyroid cancer after irradiation.

The sutdy is planed to include about 30 cases and 30 controls. Matching criteria are date of birth, gender, and age at irradiation.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    60 participants
    Observational Model:
    Case-Control
    Time Perspective:
    Retrospective
    Official Title:
    Genetic Susceptibility to Radiation Induced Thyroid Cancer
    Actual Study Start Date :
    Sep 22, 2019
    Anticipated Primary Completion Date :
    Apr 30, 2020
    Anticipated Study Completion Date :
    Apr 30, 2020

    Outcome Measures

    Primary Outcome Measures

    1. Number of Differentiated thyroid carcinoma [From hemangioma diagnosis to the end of the followup, in average 45 years after hemangioma diagnosis]

      Number of differentiated thyroid carcinoma occuring in a cohort of subjects treated for a skin hemangioma during the follow-up

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    Diganosis of thyroid cancer during the followup or selected as a control matched on gender, date of birth and age at skin hemangioma diagnosis.

    Exclusion Criteria:

    No available adress Refusal

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Gustae Roussy Villejuif Val De Marne France 948000

    Sponsors and Collaborators

    • Institut National de la Santé Et de la Recherche Médicale, France

    Investigators

    • Principal Investigator: Florent de Vathaire, PhD, Institut National de la Santé Et de la Recherche Médicale, France

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Institut National de la Santé Et de la Recherche Médicale, France
    ClinicalTrials.gov Identifier:
    NCT04139096
    Other Study ID Numbers:
    • C 17-69
    First Posted:
    Oct 25, 2019
    Last Update Posted:
    Oct 25, 2019
    Last Verified:
    Oct 1, 2019
    Additional relevant MeSH terms:
    Thyroid Neoplasms
    Thyroid Diseases
    Disease Susceptibility
    Genetic Predisposition to Disease

    Study Results

    No Results Posted as of Oct 25, 2019