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Genetic Analysis of Thyrotoxic Periodic Paralysis

Sponsor
Ramathibodi Hospital (Other)
Overall Status
Completed
CT.gov ID
NCT00443833
Collaborator
(none)
80
Enrollment
23
Duration (Months)

Study Details

Study Description

Brief Summary

Thyrotoxic periodic paralysis (TPP) is characterized by episodes of reversible hypokalemia and weakness in thyrotoxic patients. It is commonly found in males of Asian descent and is also seen in individuals having Native American or Hispanic ancestry. Therefore genetic etiology has been hypothesized. This study, we aim to find the susceptibility genes that associate with TPP. Both candidate genes approach and genome wide association study have been conducted.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    This study is a genetic association study. It included 50 cases of TPP patients and 80 cases of male, hyperthyroid patients who didn't have hypokalemia as a well characterized controls. After informed consent were obtained, genomic DNA from leukocyte were extracted. Pooled DNA were constructed and whole genome scan using 10K GeneChip microarray were genotyped on pooled genomic DNA.

    Study Design

    Study Type:
    Observational
    Observational Model:
    Case-Control
    Time Perspective:
    Other
    Official Title:
    Genetic Analysis of Thai Patients With Thyrotoxic Periodic Paralysis
    Study Start Date :
    Jan 1, 2004
    Study Completion Date :
    Dec 1, 2005

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      15 Years and Older
      Sexes Eligible for Study:
      Male
      Accepts Healthy Volunteers:
      No
      Inclusion Criteria:

      TPP

      • Hyperthyroid patients from any causes

      • Evidence of hypokalemia (k<3.5 mg/dl)from intracellular shift (Urine K<15 mg/dl, TTKG<2)

      • Episodic paralysis

      Exclusion Criteria:
      • Hypokalemia from GI or renal loss

      Contacts and Locations

      Locations

      No locations specified.

      Sponsors and Collaborators

      • Ramathibodi Hospital

      Investigators

      • Principal Investigator: Wallaya Jongjaroenprasert, MD, Endocrinology Unit, Ramathibodi Hospital, Mahidol University

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      , ,
      ClinicalTrials.gov Identifier:
      NCT00443833
      Other Study ID Numbers:
      • 11-46-21
      First Posted:
      Mar 6, 2007
      Last Update Posted:
      Mar 6, 2007
      Last Verified:
      Mar 1, 2007
      Keywords provided by , ,
      Thyrotoxicosis
      genetic association study
      periodic paralysis
      whole genome scan
      Additional relevant MeSH terms:
      Paralysis

      Study Results

      No Results Posted as of Mar 6, 2007