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Genetic Variability in Taste Perception

Sponsor
Monell Chemical Senses Center (Other)
Overall Status
Completed
CT.gov ID
NCT01841710
Collaborator
Children's Hospital of Philadelphia (Other), University of Pennsylvania (Other), National Institute on Deafness and Other Communication Disorders (NIDCD) (NIH)
90
Enrollment
1
Location
36
Duration (Months)
2.5
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This proposal describes a pilot study aimed at determining whether genetic variations in taste receptors determine differential taste tolerability of pediatric medications.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    This is a cross-sectional call-back study of taste perception and the relationship between taste perception and taste receptor genotype.

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    90 participants
    Observational Model:
    Cohort
    Time Perspective:
    Cross-Sectional
    Official Title:
    Genetic Variability in Taste Perception
    Study Start Date :
    Dec 1, 2012
    Actual Primary Completion Date :
    Dec 1, 2015
    Actual Study Completion Date :
    Dec 1, 2015

    Arms and Interventions

    Arm Intervention/Treatment
    Women

    Outcome Measures

    Primary Outcome Measures

    1. Psychophysical data for taste solutions [1-2 hours]

      Primary outcome variables are intensity ratings of pediatric medications as well as a variety of generally recognized as safe bitter and non-bitter compounds.

    Secondary Outcome Measures

    1. Maternal practices and perceptions of medication use [1-2 hours]

      Secondary outcome variables include questions related to maternal practices and perceptions of medication use and compliance of their children.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    Female
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:
    • Adult females who were previously enrolled in Efficacy of Bitter Blockers on Taste Acceptance in Pediatric Populations Study (Protocol #809789)
    Exclusion Criteria:

    • Women who are pregnant

    • Women on drugs with potential serious adverse effects that are mediated through cytochrome P450.

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Monell Chemical Senses Center Philadelphia Pennsylvania United States 19104

    Sponsors and Collaborators

    • Monell Chemical Senses Center
    • Children's Hospital of Philadelphia
    • University of Pennsylvania
    • National Institute on Deafness and Other Communication Disorders (NIDCD)

    Investigators

    • Principal Investigator: Julie A. Mennella, PhD, Monell Chemical Senses Center
    • Principal Investigator: Elizabeth Lowenthal, MD MSCE, University of Pennsylvania

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Julie A. Mennella, Member, Monell Chemical Senses Center
    ClinicalTrials.gov Identifier:
    NCT01841710
    Other Study ID Numbers:
    • 816980
    • R01DC011287
    First Posted:
    Apr 26, 2013
    Last Update Posted:
    Mar 16, 2016
    Last Verified:
    Mar 1, 2016
    Keywords provided by Julie A. Mennella, Member, Monell Chemical Senses Center
    Bitter Taste
    Pediatric Medications

    Study Results

    No Results Posted as of Mar 16, 2016