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Genetics of Schizophrenia

Sponsor
Sheba Medical Center (Other)
Overall Status
Unknown status
CT.gov ID
NCT00619437
Collaborator
(none)
100
Enrollment
1
Location
20
Duration (Months)
5
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Genetic etiology in schizophrenia is widely accepted. However, many chromosomal sites were shown to characterize the families of patients with schizophrenia. This is probably due to the high genetic heterogenity of this illness. Thus, it is important to investigate the genetic factor in relatively genetically homogenous populations. Many studies have indicate that Ashkenazy Jews show relative gentic homogenity. Indeed, the genes responsible for most Mendelian disorders of Jewish peoples have been identified. The study will apply genome-wide mutation screening methods to identify candidate allells in subjects of Ashkenazi Jewish ancestry with multiplex schizophrenia.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    100 participants
    Observational Model:
    Family-Based
    Time Perspective:
    Prospective
    Official Title:
    Genetics of Schizophrenia
    Study Start Date :
    Apr 1, 2008
    Anticipated Study Completion Date :
    Dec 1, 2009

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      18 Years to 78 Years
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      No
      Inclusion Criteria:

      1. Age 18+;

      2. Meet DSM-IV criteria for Schizophrenia;

      3. At least one first-degree relative who Meet DSM-IV criteria for Schizophrenia;

      4. Can sign the informed consent form.

      Exclusion Criteria:

      1. Patients suffering from terminal or incurabale disease;

      2. Minors, incompetents

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 Sheba Medical Center Tel Hashomer Israel

      Sponsors and Collaborators

      • Sheba Medical Center

      Investigators

      • Study Director: Michael Bunzel, MD, Psychiatric ward, Sheba Medical Center

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      , ,
      ClinicalTrials.gov Identifier:
      NCT00619437
      Other Study ID Numbers:
      • SHEBA-07-4620-RG-CTIL
      First Posted:
      Feb 21, 2008
      Last Update Posted:
      Feb 21, 2008
      Last Verified:
      Feb 1, 2008
      Keywords provided by , ,
      schizophrenia
      genetics
      family
      multiplex
      haplotypes
      Additional relevant MeSH terms:
      Schizophrenia

      Study Results

      No Results Posted as of Feb 21, 2008