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Genetics of Spina Bifida and Anencephaly

Sponsor
Duke University (Other)
Overall Status
Completed
CT.gov ID
NCT00636233
Collaborator
National Institute of Neurological Disorders and Stroke (NINDS) (NIH)
10,000
Enrollment
1
Location
291.1
Duration (Months)
34.4
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The goal of this research study is to discover the genetic and environmental factors that contribute to the cause of neural tube defects such as spina bifida and anencephaly. Ultimately, this type of research may result in improved diagnosis, improved treatment and possibly prevention.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    10000 participants
    Observational Model:
    Family-Based
    Time Perspective:
    Cross-Sectional
    Official Title:
    The Hereditary Basis of Neural Tube Defects
    Study Start Date :
    May 1, 1993
    Actual Primary Completion Date :
    Aug 2, 2017
    Actual Study Completion Date :
    Aug 2, 2017

    Arms and Interventions

    Arm Intervention/Treatment
    Anencephaly

    Fetuses with anencephaly, parents and siblings

    Outcome Measures

    Primary Outcome Measures

    1. genetic factors associated with neural tube defects [end of the study]

      This study aims to discover genetic factors associated with neural tube defects such as anencephaly.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    N/A and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No

    Not currently enrolling new participants.

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Duke University Medical Center Durham North Carolina United States 27710

    Sponsors and Collaborators

    • Duke University
    • National Institute of Neurological Disorders and Stroke (NINDS)

    Investigators

    • Principal Investigator: Allison Ashley-Koch, PhD, Duke Health

    Study Documents (Full-Text)

    None provided.

    More Information

    Additional Information:

    Publications

    None provided.
    Responsible Party:
    Duke University
    ClinicalTrials.gov Identifier:
    NCT00636233
    Other Study ID Numbers:
    • Pro00016517
    • R01NS039818
    First Posted:
    Mar 14, 2008
    Last Update Posted:
    Apr 2, 2020
    Last Verified:
    Mar 1, 2019
    Individual Participant Data (IPD) Sharing Statement:
    No
    Plan to Share IPD:
    No
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Keywords provided by Duke University
    anencephaly
    acrania
    Additional relevant MeSH terms:
    Anencephaly
    Neural Tube Defects

    Study Results

    No Results Posted as of Apr 2, 2020