GWAScollateral: Genome-wide Association Study of Development of Collateral Circulation for Patients With Coronary or Peripheral Artery Disease

• Sponsor: Jung-min Ahn (Other)
• Overall Status: Recruiting
• CT.gov ID: NCT05043948
• Collaborator: (none)
• Enrollment: 400
• Location: 1
• Anticipated Duration (Months): 124.4
• Patients Per Site Per Month: 3.2

Study Details

Study Description

Brief Summary

The purpose of this study is to evaluate the genome-wide association for the development of collateral circulation for patients with coronary or peripheral artery disease and to develop the molecular genetic treatment model based on genome-wide association data.

Condition or Disease	Intervention/Treatment	Phase
Coronary Disease; Peripheral Arterial Disease; Collateral Circulation, Any Site	Diagnostic Test: Blood samples

Study Design

• Study Type: Observational
• Anticipated Enrollment: 400 participants
• Observational Model: Cohort
• Time Perspective: Prospective
• Official Title: Genome-wide Association Study of Development of Collateral Circulation for Patients With Coronary or Peripheral Artery Disease
• Actual Study Start Date: Aug 21, 2015
• Anticipated Primary Completion Date: Jun 30, 2025
• Anticipated Study Completion Date: Dec 31, 2025

Arms and Interventions

Arm	Intervention/Treatment
Coronary Artery Disease_collateral flow grade 2	Diagnostic Test: Blood samples; for evaluation of the genome-wide association study
Coronary Artery Disease_collateral flow grade 0	Diagnostic Test: Blood samples; for evaluation of the genome-wide association study
Peripheral Artery Disease_collateral flow grade 2	Diagnostic Test: Blood samples; for evaluation of the genome-wide association study
Peripheral Artery Disease_collateral flow grade 0	Diagnostic Test: Blood samples; for evaluation of the genome-wide association study

Outcome Measures

Primary Outcome Measures

1. Correlation between genome and collateral flow [5 years]

Eligibility Criteria

Criteria

• Ages Eligible for Study: 20 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• Age more than 20

• Chronic total occlusive lesion from the coronary or peripheral angiogram

Exclusion Criteria:

• Renal dysfunction

• Hepatic dysfunction

• Thrombocythemia or thrombocythemia

• Planned major surgery in 1 year

• History of gastrointestinal haemorrhage

• Malignant tumor

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Asan Medical Center	Seoul		Korea, Republic of

Sponsors and Collaborators

• Jung-min Ahn

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Jung-min Ahn, Assistant Professor, Asan Medical Center
• ClinicalTrials.gov Identifier: NCT05043948
• Other Study ID Numbers: GWAS_collateral
• First Posted: Sep 14, 2021
• Last Update Posted: Sep 14, 2021
• Last Verified: Sep 1, 2021

• Individual Participant Data (IPD) Sharing Statement: Undecided
• Plan to Share IPD: Undecided
• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Keywords provided by Jung-min Ahn, Assistant Professor, Asan Medical Center: Genome-wide association; Collateral circulation
• Additional relevant MeSH terms: Peripheral Arterial Disease; Peripheral Vascular Diseases; Coronary Disease

Study Results

No Results Posted as of Sep 14, 2021