Genotype/Phenotype Correlation of Movement Disorders and Other Neurological Diseases
Sponsor
National Institute of Neurological Disorders and Stroke (NINDS) (NIH)
Overall Status
Completed
CT.gov ID
NCT00001667
Collaborator
(none)
300
1
37
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Study Details
Study Description
Brief Summary
The purpose of this protocol is to identify families with inherited neurologic conditions, especially movement disorders, to evaluate affected and unaffected individuals clinically, and to obtain blood samples for genetic analysis.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
|
Detailed Description
The purpose of this protocol is to identify families with inherited neurologic conditions, especially movement disorders, to evaluate affected and unaffected individuals clinically, and to obtain blood samples for genetic analysis.
Study Design
Study Type:
Observational
Official Title:
Genotype/Phenotype Correlation of Movement Disorders and Other Neurological Diseases
Study Start Date
:
Mar 1, 1997
Study Completion Date
:
Apr 1, 2000
Outcome Measures
Primary Outcome Measures
Eligibility Criteria
Criteria
Ages Eligible for Study:
N/A
and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Neurologic disease or movement disorders affecting 2 or more family members.
No conditions in which phlebotomy is contra-indicated.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | National Institute of Neurological Disorders and Stroke (NINDS) | Bethesda | Maryland | United States | 20892 |
Sponsors and Collaborators
- National Institute of Neurological Disorders and Stroke (NINDS)
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
- Higgins JJ, Nee LE, Vasconcelos O, Ide SE, Lavedan C, Goldfarb LG, Polymeropoulos MH. Mutations in American families with spinocerebellar ataxia (SCA) type 3: SCA3 is allelic to Machado-Joseph disease. Neurology. 1996 Jan;46(1):208-13.
- Ichinose H, Ohye T, Matsuda Y, Hori T, Blau N, Burlina A, Rouse B, Matalon R, Fujita K, Nagatsu T. Characterization of mouse and human GTP cyclohydrolase I genes. Mutations in patients with GTP cyclohydrolase I deficiency. J Biol Chem. 1995 Apr 28;270(17):10062-71.
- Silveira I, Lopes-Cendes I, Kish S, Maciel P, Gaspar C, Coutinho P, Botez MI, Teive H, Arruda W, Steiner CE, Pinto-Júnior W, Maciel JA, Jerin S, Sack G, Andermann E, Sudarsky L, Rosenberg R, MacLeod P, Chitayat D, Babul R, Sequeiros J, Rouleau GA. Frequency of spinocerebellar ataxia type 1, dentatorubropallidoluysian atrophy, and Machado-Joseph disease mutations in a large group of spinocerebellar ataxia patients. Neurology. 1996 Jan;46(1):214-8.
Responsible Party:
,
,
ClinicalTrials.gov Identifier:
NCT00001667
Other Study ID Numbers:
- 970097
- 97-N-0097
First Posted:
Dec 10, 2002
Last Update Posted:
Mar 4, 2008
Last Verified:
Feb 1, 1999
Keywords provided by ,
,
Additional relevant MeSH terms: