HASA: Geriatric HIV Cohort in Sub Sahara Africa
Study Details
Study Description
Brief Summary
The overall goal of the proposal is to improve capacity for detection and management of non-communicable diseases and geriatric syndromes in the aging HIV population in sub-Saharan Africa
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Detailed Description
The establishment and scale up of solid and sustainable HIV programs in sub-Saharan Africa (SSA) has led to a reduction in mortality and morbidity from HIV related opportunistic infections and some HIV related cancers. This improved survival has resulted in two phenomena: the first is the surfacing of non-communicable diseases (NCDs) in the HIV population, especially in those on long-term ART, and the second is increased longevity leading to increasing numbers of elderly HIV infected individuals
Study Design
Outcome Measures
Primary Outcome Measures
- Change in proportion of participants with any non communicable disease [Enrollment, year 1, year 2]
Proportion with any non communicable disease (including hypertension, cardio vascular disease, respiratory disease, renal disease, non HIV related cancers, frailty)
- Change in Quality of life [Enrollment, year 1, year 2]
Quality of life measured using the WHO Quality of life for elderly (WHOQOL-OLD)
Secondary Outcome Measures
- Change in proportion of patients with polypharmacy monitoring [Enrollment, year 1, year 2]
Polypharmacy defined as 5 or more drugs beyond antiretroviral drugs, used in the same individuals for more than 4 weeks. Information of polypharmacy will be collected by the clinic files and self reported by the participants
- Change in Nutritional status assessed by Mini Nutritional Assessments (MNA) [Enrollment, year 1, year 2]
Nutrition screening and assessment to identify geriatric patients age who are malnourished or at risk of malnutrition.
- Change in proportion of patients with history of falls [Enrollment, year 1, year 2]
Occurrence of falls measured with the History of Falls questionnaire
- Change in proportion of patients with urinary incontinence measured by ICIQ-UI Short [Enrollment, year 1, year 2]
Presence of urinary incontinence measured with the Internal Consultation on Incontinence Questionnaire
- Change in proportion of patients with depression [Enrollment, year 1, year 2]
Depression measurement using the People Health Questionnaire-9 (scale 0-30, higher: worse)
- Change in proportion of patients with disability [Enrollment, year 1, year 2]
Assessment of the Instrumental Activities of Daily Living (score 0-8, higher: better)
- Change in proportion of patients with cognitive deficit [Enrollment, year 1, year 2]
Screening using Montreal Cognitive Assessment (score 0-30; higher: better)
Eligibility Criteria
Criteria
Inclusion Criteria:
Age 60 years and above
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Evidence of a personally signed and dated informed consent document indicating that the subject (or a legal representative) has been informed of all pertinent aspects of the study.
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Subjects who are willing and able to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures.
Exclusion Criteria:
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Any clinical (physical and psychiatric) condition which prevents the patients to participate safely in the study procedures according to the judgments of a physician.
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Subjects already enrolled in experimental clinical trial.
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Makerere University
Investigators
- Principal Investigator: Barbara Castelnuovo, PhD, Infectious Diseases Institute (IDI)
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- TMA2017GSF-1936