WGDC: Wenzhou Gestational Diabetes Cohort
Study Details
Study Description
Brief Summary
The Wenzhou Gestational Diabetes Cohort (WGDC) is a prospective cohort study among women with gestational diabetes mellitus (GDM) during pregnancy and their offspring living in Wenzhou, China. The primary aim of this cohort is to characterize the continuous blood glucose response to dietary intake and physical activity among pregnant women with GDM over 2 weeks, and to facilitate the development of personalized nutritional/lifestyle recommendation among these patients. Another aim of the WGDC is to investigate the association of dietary and physical activity together with continuous glucose change during pregnancy on the adverse birth outcomes including preterm birth, macrosomia and large-for-gestational-age birth. The secondary aim is to investigate the prospective associations of diet, physical activity and continuous glucose change over 2 weeks among the patients with long-term metabolic health of the women and their offspring.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
In China, an alarming increase in the prevalence of GDM has been observed in the past decade. GDM is of concern because it is associated with several maternal and fetal medical disorders. Lifestyle changes such as diet and physical activity modifications are key for the prevention and treatment of GDM. However, the associations between dietary intake and physical activity and health outcomes for GDM women and their children remain unclear due to subjective measurements of diet and physical activity. Recently, the development of objective measurements such as food image identification and wearable activity trackers give an opportunity to gain more precise insight into these associations. In addition, for the same food and physical activity exposure, GDM women may have different blood glucose responses, but the nature of variation is currently poorly characterized. Therefore, the present WGDC design incorporates three unique components, 1) objective measurement of physical activity during pregnancy using accelerometer; 2) measurement of dietary intake using both Food Frequency Questionnaire and daily dietary records; 3) measurement of blood glucose levels over 2 weeks using continuous glucose monitors, with three standardized test meals during the 2 weeks. We will then follow up these women participants during and after this pregnancy, and also follow up their offspring.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Other: Standardized breakfast Egg (50g), whole-wheat bread (35g), celery (30g), and dried bean curd (10g) |
Other: Standardized breakfast
Participants will be provided with a standardized breakfast on a morning of the days they wear a continuous glucose monitoring (CGM) device.
|
| Other: Standardized snack Tomato (50g) and skim milk (200g) |
Other: Standardized snack
Participants will be provided with a standardized snack 2 hour after they have the standardized breakfast.
|
| Other: Standardized lunch Rice (40g), oats (40g), shrimp (70g), lettuce (80g), lean pork (30g), carrot (10g), soaked auricularia auricula (20g), broccoli (80g), cucumber (10g), tomato egg drop soup (200g), salt (3g), and oil (8g) |
Other: Standardized lunch
Participants will be provided with a standardized lunch 2 h after they have the standardized snack.
|
Outcome Measures
Primary Outcome Measures
- Continuous blood glucose change over 2 weeks [two weeks after enrollment]
Glucose levels are assessed by continuous glucose monitoring over 2 weeks.
- Adverse birth outcomes [9-12 weeks after enrollment]
Number of participants with adverse birth outcomes, such as, preterm birth, macrosomia and neonatal hypoglycemia.
Secondary Outcome Measures
- Weight changes during early childhood [at delivery, age of 6 months, 1 year, 3 years and 6 years]
Weight in kilograms
- Number of participants developing type 2 diabetes [6 years and 10 years after delivery]
Risk of developing type 2 diabetes after the delivery of the women with gestational diabetes.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Women aged 18 years or older
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Women with GDM mainly at 24-28 weeks of gestation
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Women intended to deliver at Wenzhou People's Hospital
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Women intended to remain in Wenzhou with their child for ≥4 years
Exclusion Criteria:
- Women with cancer and other serious medical disorders
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Wenzhou People's Hospital | Wenzhou | Zhejiang | China | 325000 |
Sponsors and Collaborators
- Westlake University
- Wenzhou People's Hospital
Investigators
- Principal Investigator: Ju-Sheng Zheng, PhD, Westlake University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 20221213ZJS001