Evaluation of Antioxidant and Anti-inflammatory Effect of Matcha Tea Intake on Periodontal Health

• Sponsor: Hayder Raad Abdulbaqi (Other)
• Overall Status: Active, not recruiting
• CT.gov ID: NCT05681325
• Collaborator: (none)
• Enrollment: 40
• Location: 1
• Arms: 2
• Anticipated Duration (Months): 17.5
• Patients Per Site Per Month: 2.3

Study Details

Study Description

Brief Summary

Aim of the study:

This study aims to evaluate the antioxidant and beneficial effects of matcha tea daily intake on periodontal health.

Objectives:

• To evaluate the salivary level of antioxidants (catalase, total antioxidant capacity) after matcha tea intake compared to green tea over a period of one month.

• To evaluate the clinical periodontal parameters including bleeding on probing (BOP), probing pocket depth (PPD) and plaque index (PI) after matcha tea intake compared to green tea over a period of one month.

• To evaluate the salivary levels of IL-1B after matcha tea intake compared to green tea over a period of one month.

Condition or Disease	Intervention/Treatment	Phase
Gingival Disease	Dietary Supplement: green tea; Dietary Supplement: matcha tea	N/A

Study Design

• Study Type: Interventional
• Anticipated Enrollment: 40 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: Single (Investigator)
• Primary Purpose: Treatment
• Official Title: Evaluation of Antioxidant and Anti-inflammatory Effect of Matcha Tea Intake on Periodontal Health
• Actual Study Start Date: Jan 25, 2022
• Anticipated Primary Completion Date: Apr 12, 2023
• Anticipated Study Completion Date: Jul 12, 2023

Arms and Interventions

Arm	Intervention/Treatment
Active Comparator: green tea group Mahmood Green Tea Sri Lanka. It will be given 2 cups / day for 30 days.	Dietary Supplement: green tea; It will be given 2 cups / day for 30 days. To prepare each cup, a tea pack will be immersed into a cup of hot water.
Experimental: matcha tea group Jade Leaf Organic Japanese Matcha, USA. It will be given 2 cups / day for 30 days.	Dietary Supplement: matcha tea; It will be given 2 cups / day for 30 days. To prepare each cup, a tea pack will be immersed into a cup of hot water.

Outcome Measures

Primary Outcome Measures

1. change in salivary level of antioxidant marker [30 Days (baseline to one moth of tea intake)]

   change in level of catalase enzyme in ku/L

2. change in salivary level of ant-inflammatory marker [30 Days (baseline to one moth of tea intake)]

   change in level of interleukin- one beta (IL-1B) in pg/L

Secondary Outcome Measures

1. change in percentage of bleeding on probing (BOP) [30 Days (baseline to one moth of tea intake)]

   change in BOP percentage. less percentage means less inflammation in gingival tissue

2. change in plaque index (PI) scores [30 Days (baseline to one moth of tea intake)]

   change in PI scores. less scores mean less dental plaque accumulated onto teeth surfaces

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 40 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• • having at least 20 teeth,

• underwent no medical treatment during the last 3 months before examination and sampling,

• non-smoker,

• no history of systemic disease,

• gingivitis patient (having >10% bleeding sites with no PPD >3 mm).

Exclusion Criteria:

• • wore orthodontic appliances,

• pregnant or currently in the breast-feeding period,

• periodontitis patient,

• smoker,

• has a history of systemic disease.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Universality of Baghdad, College of dentistry	Baghdad		Iraq

Sponsors and Collaborators

• Hayder Raad Abdulbaqi

Investigators

• Study Director: HIND KAREEM, BDS, University of Baghdad, College of Dentistry

Study Documents (Full-Text)

None provided.

More Information

Publications

• Kolackova T, Kolofikova K, Sytarova I, Snopek L, Sumczynski D, Orsavova J. Matcha Tea: Analysis of Nutritional Composition, Phenolics and Antioxidant Activity. Plant Foods Hum Nutr. 2020 Mar;75(1):48-53. doi: 10.1007/s11130-019-00777-z.
• Zhang Y, Kang N, Xue F, Qiao J, Duan J, Chen F, Cai Y. Evaluation of salivary biomarkers for the diagnosis of periodontitis. BMC Oral Health. 2021 May 17;21(1):266. doi: 10.1186/s12903-021-01600-5.

• Responsible Party: Hayder Raad Abdulbaqi, professor, University of Baghdad
• ClinicalTrials.gov Identifier: NCT05681325
• Other Study ID Numbers: matcha on periodontal health
• First Posted: Jan 12, 2023
• Last Update Posted: Jan 12, 2023
• Last Verified: Jan 1, 2023

• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Additional relevant MeSH terms: Gingival Diseases

Study Results

No Results Posted as of Jan 12, 2023