Changes in Ocular Rigidity After Trabeculectomy in Patients With POAG
Study Details
Study Description
Brief Summary
It has been hypothesized that the biomechanical properties of the optic nerve head and/or sclera play a role in the development of glaucoma. One approach of gaining insight into the biomechanical properties of the eye by the means of clinical studies is based on the Friedenwald equation, representing a pressure-volume relationship. This equation represents the so called ocular rigidity, which expresses the elasticity of the globe.
In order to be able to solve the equation, measurements of fundus pulsation amplitude (FPA) with laser interferometry and dynamic contour tonometric assessment of the pulse amplitude (PA) have to be performed.
In addition choroidal thickness will be assessed with OCT before and after trabeculectomy, since results in choroidal thickness measurements in patients with glaucoma are controversial.
The focus of this study lies on the changes of ocular rigidity and choroidal thickness after surgical trabeculectomy in patients with primary open angle glaucoma (POAG) or pseudoexfoliation glaucoma (PEX).
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Other: trabeculectomy
|
Other: Changes in Ocular rigidity
measured before the operation and 28±7 days after the operation
|
Outcome Measures
Primary Outcome Measures
- Change in ocular rigidity [Baseline and 28±7 days postoperative]
Change in ocular rigidity after surgery
Secondary Outcome Measures
- Fundus pulsation amplitude [Baseline and 28±7 days postoperative]
- Ocular pulse amplitude [Baseline and 28±7 days postoperative]
- Mean arterial pressure [Baseline and 28±7 days postoperative]
- Pulse rate [Baseline and 28±7 days postoperative]
- Axial eye length [Baseline and 28±7 days postoperative]
- choroidal thickness [Baseline and 28±7 days postoperative]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Men and women aged over 18 years
-
Normal ophthalmic findings except POAG or Pseudoexfoliation glaucoma (PEX)
-
Patients scheduled for trabeculectomy
Exclusion Criteria:
-
Participation in a clinical trial in the 3 weeks preceeding the study
-
Symptoms of a clinically relevant illness in the 3 weeks before the first study day
-
Presence or history of a severe medical condition that will interfere with the study aim as judged by the clinical investigator
-
Other types of glaucoma, such as pigmentary glaucoma, history of acute angle closure
-
History of previous glaucoma surgery
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Postoperative IOP ≤ 8 mmHg
-
Ocular inflammation or infection within the past 3 months
-
Topical treatment with any ophthalmic drug except anti-glaucomatous medication
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Department of Clinical Pharmacology, Medical University of Vienna | Vienna | Austria | 1090 |
Sponsors and Collaborators
- Medical University of Vienna
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- OPHT-040411