Dose Escalation Study to Determine the Safety of IFN-Beta Gene Transfer in the Treatment of Grade III & Grade IV Gliomas

Sponsor

Biogen (Industry)

Overall Status

Completed

CT.gov ID

NCT00031083

Collaborator

(none)

Enrollment

Locations

18.3

Actual Duration (Months)

2.4

Patients Per Site

0.1

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

In this study an investigational replication-defective, recombinant adenovirus expressing the interferon-beta gene (BG00001) will be directly injected into tumors, in patients with recurrent Grade III and Grade IV Gliomas, in order to deliver the hIFN-beta gene. The purpose of the study is to evaluate the safety and any harmful effects of injection of BG00001 into brain tumors. Also, this study will help determine whether the virus carrying the beta interferon gene will enter brain tumor cells and cause the cancer cells to die. This study will require one hospital admission for the actual procedure of drug administration. All other visits will be conducted on an out-patient basis

Condition or Disease	Intervention/Treatment	Phase
Glioblastoma Multiforme Anaplastic Astrocytoma Oligoastrocytoma, Mixed Gliosarcoma	Genetic: Interferon-beta	Phase 1

Study Design

Study Type:

Interventional

Allocation:

Non-Randomized

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Primary Purpose:

Treatment

Official Title:

A Multi-center, Open Label, Two Part, Dose Escalation Study to Determine the Tolerability of Interferon-Beta Gene Transfer (BG00001) in the Treatment of Recurrent or Progressive Grade III and Grade IV Gliomas

Actual Study Start Date :

Apr 2, 2002

Actual Study Completion Date :

Oct 10, 2003

Outcome Measures

Primary Outcome Measures

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Must be greater than or equal to 18 years of age.
Subjects must have histologically proven GBM, AA, AMO, malignant astrocytoma NOS or gliosarcoma and recurrent or progressive tumor following prior treatment.
Tumor must be amenable to radical resection, and resection must be clinically indicated.
Must have an ECOG performance status of 0-2.
Must be on anticonvulsant therapy, and must have therapeutic serum levels within 2 weeks prior to Day 1, if therapeutic levels are defined for the anticonvulsant being used.

Exclusion Criteria:

Abnormal blood tests exceeding any of the limits defined below:

Alanine transaminase (ALT) > four times (4X) the upper limit of normal (ULN).
Aspartate transaminase (AST) > 4X the ULN.
Total bilirubin >1.5 mg/dL.
Absolute neutrophil count <1,500 cells/mm3.
Platelet count <100,000 cells/mm3.
Serum creatinine >2X ULN.
Prothrombin time (PT) >2 seconds above the ULN.
Serum sodium (Na) <125 mEq/L or >150 mEq/L.
Serum potassium (K) <3.5 mEq/L or > 5.5 mEq/L.

Brainstem, or optic chiasm involvement of tumor.
Uncontrolled seizure disorder.
History of a new diagnosis or treatment of an invasive malignancy other than Grade III or Grade IV Glioma within 5 years of enrollment. Curatively treated subjects with a history of basal cell or squamous cell carcinoma of the skin, superficial transitional cell carcinoma of the bladder, and non-invasive carcinoma of the uterine cervix are not excluded.

Treatment History:

Treatment with radiation therapy, including interstitial radiation or radiosurgery, must be completed at least 8 weeks prior to Day 1.
Treatment with nitrosoureas must be completed at least 6 weeks prior to Day 1. Treatment with other chemotherapeutic agents must be completed at least 4 weeks prior to Day 1.
Treatment with any investigational drug or approved therapy for investigational use must be completed at least 4 weeks prior to Day 1.
History of intolerance to corticosteroids that would preclude use during this study, or history of any medical condition that precludes the use of corticosteroids.
Any prior treatment with a gene delivery vector, or an adenovirus therapeutic.
Women of child bearing potential must have a negative serum pregnancy test.
Women who are not postmenopausal, surgically sterile, or willing to practice effective contraception during the study. Men who are not surgically sterile or willing to practice effective contraception during the study.
Nursing mothers, pregnant women and women planning to become pregnant while on study.
Previous treatment with BG00001.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	University of Alabama at Birmingham	Birmingham	Alabama	United States	35294
2	University of Arizona at Tucson	Tucson	Arizona	United States	85724
3	University of Colorado Health Sciences Center	Denver	Colorado	United States	80262
4	Massachusetts General Hospital	Boston	Massachusetts	United States	2114
5	Hospital of the University of Pennsylvania	Philadelphia	Pennsylvania	United States	19104