HT: Metabolic Adaptations in Response to High Intensity Interval Training in Obese Adults
Study Details
Study Description
Brief Summary
The overall objectives are to:
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Assess mechanisms underlying HIIT-induced improvements in insulin resistance at the whole-body, tissue, and cellular levels.
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Systematically compare different HIIT regimens to help identify effective "doses" of HIIT that may be optimal for improving metabolic health in obese adults.
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Assess the ability/willingness of obese subjects to adhere to a long-term HIIT program.
Findings from these studies will greatly expand knowledge about the effects of HIIT on metabolic health, and will provide valuable information for development of programs aimed at maximizing key metabolic benefits of exercise.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
If subjects are eligible for the study, they will be randomized into one of four different exercise training groups. Before training (and twice after 3 months of training) subjects will participate in a "clinical study" in which they will be required to stay overnight in the hospital. During the clinical study, the research team will perform a series of metabolic tests. Before and after the 3 months of training, the research team will assess subjects "free-living" 24h blood sugar control using a Continuous Glucose Monitor (CGM). The research team will measure several other relevant clinical markers (e.g., whole body and regional body fat assessments [Dual Energy X-ray Absorptiometry (DEXA) and Magnetic Resonance Imager (MRI)], hepatic lipid accumulation [MRI analysis], blood lipid profile, resting metabolic rate, glycated hemoglobin [hemoglobin A1c]). After the first 3 months of training, adherence to the subjects assigned training program will be tracked for the next 9 months (1 year of training in total). One year after initiating a training program, subjects will be asked to return to the clinic for a quick follow-up visit where the research team will complete some standard clinical assessments (e.g., body weight, body composition, blood pressure, and a blood sample).
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Other: High Intensity Interval Training #1 Obese adults with impaired glucose tolerance will be randomized into one of four different exercise training groups for a 3 month exercise intervention. |
Other: High Intensity Interval Training #1
(HIIT#1) 10 x 1 min. at ~90%HRmax - with low intensity warm-up, recovery, and cool down - total of 25 min/session .
|
| Other: Moderate intensity continuous training Obese adults with impaired glucose tolerance will be randomized into one of four different exercise training groups for a 3 month exercise intervention. |
Other: Moderate intensity continuous training
Moderate-intensity continuous training (MICT) = steady-state exercise at 60-70%HRmax for 45min. Representing a commonly prescribed exercise program.
|
| Other: High Intensity Interval Training #2 Obese adults with impaired glucose tolerance will be randomized into one of four different exercise training groups for a 3 month exercise intervention. |
Other: High Intensity Interval Training #2
(HIIT #2) 5 x 1 min at 90%HRmax + 10 min steady-state exercise at 70%HRmax [25min; ~150kcals; 4d/wk]
|
| Other: High Intensity Interval Training #3 Obese adults with impaired glucose tolerance will be randomized into one of four different exercise training groups for a 3 month exercise intervention. |
Other: High Intensity Interval Training #3
(HIIT #3) 5 x 1 min at 90%HRmax [15min; ~90kcals; 4d/wk]
|
Outcome Measures
Primary Outcome Measures
- Insulin Sensitivity [Change from Baseline at 3 months]
A hyperinsulinemic-euglycemic clamp will be used to assess peripheral insulin sensitivity
Secondary Outcome Measures
- Continuous Glucose Monitoring [Change from Baseline at 3 months]
- Resting Metabolic Rate [baseline and 3 months]
- Muscle Biopsy [Change from Baseline at 3 months]
To measure Mitochondrial Proteins
- Adipose Tissue Biopsy [Change from Baseline at 3 months]
To measure cytokines
Eligibility Criteria
Criteria
Inclusion Criteria:
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Age: 18-40
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Body Mass Index: 30-40 kg/m2
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Waist circumference: 88-98cm for women and 100-110cm for men
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Glucose intolerant (i.e., 2h glucose concentration during a screening oral glucose tolerance test (OGTT)= 140-199mg/dl
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No regularly planned exercise/physical activity
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Women must have regularly occurring menses and must be premenopausal
Exclusion Criteria:
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EKG abnormalities as assessed by the cardiologist on the research team
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Evidence/history of cardiovascular or metabolic disease
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Medications known to affect lipid or glucose metabolism
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Pregnant or lactating
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Tobacco or e-cigarette use
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Suzette Howton | Ann Arbor | Michigan | United States | 48178 |
Sponsors and Collaborators
- University of Michigan
Investigators
- Principal Investigator: Jeff Horowitz, University of Michigan
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- HUM00106883