Obesity: Effect of Meal Texture on Glucose-metabolism and Gut Hormone Response After Bariatric Surgery
Study Details
Study Description
Brief Summary
The investigators want to evaluate the difference in glucose metabolism and intestinal hormonal response after a liquid meal versus a solid meal in patients after bariatric surgery.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
N/A |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Other: Gastric bypass operated patients Two test days in a randomized, patient-blinded, cross-over design |
Other: Liquid meal
Four-hour liquid mixed meal test
Other: Solid meal
Four-hour solid mixed meal test
|
Other: Gastric sleeve operated patients Two test days in a randomized, patient-blinded, cross-over design |
Other: Liquid meal
Four-hour liquid mixed meal test
Other: Solid meal
Four-hour solid mixed meal test
|
Other: Control arm Two test days in a randomized, patient-blinded, cross-over design |
Other: Liquid meal
Four-hour liquid mixed meal test
Other: Solid meal
Four-hour solid mixed meal test
|
Outcome Measures
Primary Outcome Measures
- GLP-1 response [240 minutes]
GLP-1 response after a liquid meal test compared to a solid meal test
Secondary Outcome Measures
- Difference in gut hormone response after bariatric surgery [240 minutes]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Age > 18 years
-
RYGB or SG operation > 12 months prior to inclusion
-
Weight stable (± 3 kg during the last month)
-
HbA1c < 48 mmol/mol before surgery, and no history of diabetes
-
HbA1c < 48 mmol/mol and fasting plasma glucose < 6.1 mmol/l at inclusion
Exclusion Criteria:
-
Thyrotoxicosis or inadequately treated hypothyreosis
-
Hemoglobin < 6.5 mmol/l at inclusion
-
Pregnancy or breast feeding
-
Medication affecting the planned examinations
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Department of Endocrinology, Hvidovre University Hospital | Copenhagen | Hvidovre | Denmark | 2650 |
Sponsors and Collaborators
- Hvidovre University Hospital
Investigators
- Principal Investigator: NOra Hedbäck, MD, Department of Endocrinology Hvidovre Hospital Denmark
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- H-19027100