Glucose Metabolism and Sleep in People With Family History of Type 2 Diabetes.

Sponsor

University of Chicago (Other)

Overall Status

Completed

CT.gov ID

NCT00720889

Collaborator

National Heart, Lung, and Blood Institute (NHLBI) (NIH)

Enrollment

Location

Duration (Months)

0.5

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The use of sugar and starch-like foods for energy (carbohydrate metabolism) changes when people sleep. However, it is still not known if differences in the amount of nighttime sleep have an effect on the carbohydrate metabolism of people who have a relative with type 2 diabetes (parent, sibling, or grandparent). This study is being done to test the hypothesis that individual differences in habitual sleep duration may be related to differences in the carbohydrate metabolism of people who have a history of type 2 diabetes in their family.

Condition or Disease	Intervention/Treatment	Phase
Sleep Insulin Resistance Type 2 Diabetes

Detailed Description

On two consecutive inpatient days, the participants in this study will undergo two different tests. The first test will determine how much insulin can their body produce in response to an intravenous glucose infusion over a period of several hours. The second test will determine how effective is the action of the sugar-processing hormone, insulin, in their body when it is infused intravenously together with glucose over a period of several hours.

Study Design

Study Type:

Observational

Actual Enrollment :

20 participants

Observational Model:

Case-Control

Time Perspective:

Cross-Sectional

Official Title:

Sleep, Energy Metabolism and Diabetes Risk.

Study Start Date :

Jul 1, 2008

Actual Primary Completion Date :

Mar 1, 2012

Actual Study Completion Date :

Mar 1, 2012

Arms and Interventions

Arm	Intervention/Treatment
Reduced sleep Habitual sleep duration of less than 6 hours per night on most days of the week and total sleep of less than 43 hours per week.
Reference sleep Habitual sleep duration between 7 and 8.5 hours per night on most days of the week and total sleep of at least 53 hours per week.

Outcome Measures

Primary Outcome Measures

Total body insulin sensitivity [at the end of a 4-hour hyperinsulinemic clamp]

Secondary Outcome Measures

First and second phase insulin secretion [during a 3-hour hyperglycemic clamp]
Endogenous glucose production [before and during a 4-hour hyperinsulinemic clamp]
Glycerol turnover and free fatty acid concentration [before and during a 4-hour hyperinsulinemic clamp]