Glutamatergic Amino Acids and Oxytocin Levels in the Plasma of Patients in First Psychotic Episode (FPE)- Before and After Neuroleptic Treatment
Study Details
Study Description
Brief Summary
The goal of our research is to check the levels of D-Serine, Glycine, and other Glutamatergic amino acids, in patients with First Psychotic Episode (FPE). These patients are in the early stage of the disease, treated with neuroleptics for short periods of time, and are usually hospitalized for the first time. The hypothesis of the research is that we will find low levels of Glycine and D-Serine in these patients. Following an Anti-psychotic treatment we will expect these levels to return to the norm, and that this correction will be accompanied by a reduction of positive and negative symptoms.
In addition, we will check the D-Serine and Glycine levels in the plasma of first degree relatives of the patients and a group of healthy subjects. The results of this study might support the hypothesis that the Glutamatergic system in involved in the pathology of Schizophrenia from it's early stages.
In addition, we will check the levels of Oxytocin and Estrogen in the plasma of patients in FPE. Our hypothesis is that we will find low levels of Estrogen and High levels of Oxytocin in this group of patients. The results of the study might support the hypothesis that Estrogen and Oxytocin are involved in the pathology of Schizophrenia from it's early stages.
Condition or Disease | Intervention/Treatment | Phase |
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Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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1 40 subjects in a First Psychotic Episode |
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2 20 First Degree relatives |
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3 20 Healthy subjects |
Outcome Measures
Primary Outcome Measures
- Glycine and D-Serine levels in the plasma. [6-8 weeks]
Eligibility Criteria
Criteria
Inclusion Criteria:
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Subjects between 18-60 years
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Clinical Diagnosis of Schizophrenia, Schizophreniphorm disorder, Schizoaffective Disorder, Brief esychotic episode
Exclusion Criteria:
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two years or more of positive symptoms
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Neuroleptic treatment for more then twe weeks in the prior month, or for more then six weeks at any time.
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Drug induced psychotic episode
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Shalvata Medical Center | Hod Hasharom | Israel |
Sponsors and Collaborators
- Shalvata Mental Health Center
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- uriel111