Comparison of the Effects of TIVA vs VIMA on Content of GSK-3beta in Leucocytes in On-pump Patients
Sponsor
Moscow Regional Research and Clinical Institute Moniki n.a. M.F. Vladimirskiy (Other)
Overall Status
Terminated
CT.gov ID
NCT02686710
Collaborator
(none)
10
1
3
34
0.3
Study Details
Study Description
Brief Summary
Assessment of GSK-3beta contents in leukocytes in on-pump cardiosurgical patients receiving either volatile or intravenous anesthesia
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
| Phase 4 |
Study Design
Study Type:
Interventional
Actual Enrollment
:
10 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
None (Open Label)
Primary Purpose:
Diagnostic
Official Title:
Comparison of the Effects of TIVA vs VIMA on Content of GSK-3beta in Leucocytes in On-pump Patients: a Randomized Clinical Trial
Study Start Date
:
Feb 1, 2016
Actual Primary Completion Date
:
Dec 1, 2018
Actual Study Completion Date
:
Dec 1, 2018
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Active Comparator: VIMA Patiens receiving volatile induction and maitenance of anesthesia |
Drug: Sevoflurane
|
| Active Comparator: TIVA Patiens receiving total intravenous anesthesia based on propofol |
Drug: Propofol
|
| Active Comparator: Combi Patiens receiving total intravenous induction and volatile anesthesia |
Drug: Sevoflurane
Drug: Propofol
|
Outcome Measures
Primary Outcome Measures
- Gsk-3beta base line content [base line]
- Gsk-3beta content after induction [20 minutes after tracheal intubation]
- Gsk-3beta content after surgery [immediately after surgery]
Eligibility Criteria
Criteria
Ages Eligible for Study:
18 Years
to 80 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
elective on-pump CABG
Exclusion Criteria:
re-operation
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Moscow Regional Research and Clinical Institute Moniki n.a. M.F. Vladimirskiy | Moscow | Russian Federation | 129110 |
Sponsors and Collaborators
- Moscow Regional Research and Clinical Institute Moniki n.a. M.F. Vladimirskiy
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
Valery V. Likhvantsev, Professor,
senior researcher, Moscow Regional Research and Clinical Institute Moniki n.a. M.F. Vladimirskiy,
Moscow Regional Research and Clinical Institute Moniki n.a. M.F. Vladimirskiy
ClinicalTrials.gov Identifier:
NCT02686710
Other Study ID Numbers:
- GSK-TV-L
First Posted:
Feb 19, 2016
Last Update Posted:
Aug 15, 2019
Last Verified:
Aug 1, 2019