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The Effect of Local Injectet GH on the Collagen Synthesis in the Ligamentum Patella

Sponsor
University of Aarhus (Other)
Overall Status
Completed
CT.gov ID
NCT01158612
Collaborator
Bispebjerg Hospital (Other)
12
Enrollment
1
Location
2
Arms
12
Duration (Months)
1
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Tendon and ligament injuries are a frequent problem among athletes but also in the general population. The healing process is a prolonged process, and complete recovery of tissue strength is nearly never reached. The purpose of this study is to examine the effect of local injection of human Growth Hormone on tendon collagen synthesis.

Condition or Disease Intervention/Treatment Phase
  • Drug: Growth Hormone
 N/A

Detailed Description

Tendon and ligament injuries are a frequent problem among athletes but also in the general population. The healing process is a prolonged process, and complete recovery of tissue strength is nearly never reached. The purpose of this study is to examine the effect of local injection of human Growth Hormone on tendon collagen synthesis.

in order to investigate the collagen synthesis potential and the influence of growth hormone, 12 elderly males age > 50 year, is enrolled in this study.

Study Design

Study Type:
Interventional
Actual Enrollment :
12 participants
Allocation:
Non-Randomized
Intervention Model:
Parallel Assignment
Masking:
Double (Participant, Care Provider)
Primary Purpose:
Treatment
Official Title:
The Effect of Local Injectet GH on the Collagen Synthesis in the Ligamentum Patella
Study Start Date :
Aug 1, 2010
Actual Primary Completion Date :
Jul 1, 2011
Actual Study Completion Date :
Aug 1, 2011

Arms and Interventions

Arm Intervention/Treatment
Experimental: Growth hormone

The effect of Growth hormone on the collagen synthesis rate

Drug: Growth Hormone
infusion of Growth hormone in the patella tendon.
Other Names:
  • infusion of Saline in the patella tendon.

    		•
    Placebo Comparator: Saline

    Drug: Growth Hormone
    infusion of Growth hormone in the patella tendon.
    Other Names:
  • infusion of Saline in the patella tendon.

    		•

    Outcome Measures

    Primary Outcome Measures

    1. • Fraktionele collagen protein synthesis in human patella tendon [01122010]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    55 Years to 70 Years
    Sexes Eligible for Study:
    Male
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:
    • BMI 18.5 - 25.0
    Exclusion Criteria:
    • earlier knee injury

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Århus universitetshospital nørrebrogade 44 Århus C Denmark 8000

    Sponsors and Collaborators

    • University of Aarhus
    • Bispebjerg Hospital

    Investigators

    • Principal Investigator: Mette Hansen, PH.D.,

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    University of Aarhus
    ClinicalTrials.gov Identifier:
    NCT01158612
    Other Study ID Numbers:
    • H-2-2010-039
    First Posted:
    Jul 8, 2010
    Last Update Posted:
    Nov 6, 2011
    Last Verified:
    Nov 1, 2011
    Additional relevant MeSH terms:
    Hormones

    Study Results

    No Results Posted as of Nov 6, 2011