Study of Gulf War Illness (GWI) by Comparing GWI and Healthy Veterans
Study Details
Study Description
Brief Summary
Determine if:
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genetic differences of CNDP1 gene
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the previously defined GWI/Chronic Fatigue Syndrome (GWI/CFS) cerebrospinal fluid proteome contents
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psychometric
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other variables can differentiate between veterans of the 1990-1991 Persian Gulf War who have autonomic, neurological and other symptoms and those without these complaints.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| 1 GWI: veterans of the 1990-1991 Persian Gulf War who have autonomic, neurological and other symptoms |
|
| 2 HC: healthy veterans of the 1990-1991 Persian Gulf War |
Outcome Measures
Primary Outcome Measures
Eligibility Criteria
Criteria
Inclusion Criteria:
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Evidence of military enlistment between August 1, 1990 and July 31, 1991, and deployment for 30 consecutive days to:
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Persian Gulf waters and adjacent land areas
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Other global locations
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U.S. only
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Status prior to 1990 and 1991:
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Active duty
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National Guard
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Reserves
Exclusion Criteria:
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Current active duty military personnel
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Any one who was not active duty military personnel between August 1, 1990 and July 31, 1991
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HIV/AIDS; pregnancy or lactation; potential hepatitis; drug addiction; chronic inflammatory, infectious, or autoimmune medical illnesses not associated with GWI; incarceration; dementia, other cognitive limitation; or reliance on a care-giver in order to respond to the questionnaires and other study tests.
Amputations of one or both hands and forearms will be permitted but hand grip tests will not be tested
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Georgetown University | Washington | District of Columbia | United States | 20007 |
Sponsors and Collaborators
- Georgetown University
- U.S. Army Medical Research and Development Command
Investigators
- Principal Investigator: James N Baraniuk, MD, Georgetown University
Study Documents (Full-Text)
None provided.More Information
Additional Information:
Publications
- Baraniuk JN, Casado B, Maibach H, Clauw DJ, Pannell LK, Hess S S. A Chronic Fatigue Syndrome - related proteome in human cerebrospinal fluid. BMC Neurol. 2005 Dec 1;5:22.
- Casado B, Zanone C, Annovazzi L, Iadarola P, Whalen G, Baraniuk JN. Urinary electrophoretic profiles from chronic fatigue syndrome and chronic fatigue syndrome/fibromyalgia patients: a pilot study for achieving their normalization. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Jan 5;814(1):43-51.
- Fukuda K, Nisenbaum R, Stewart G, Thompson WW, Robin L, Washko RM, Noah DL, Barrett DH, Randall B, Herwaldt BL, Mawle AC, Reeves WC. Chronic multisymptom illness affecting Air Force veterans of the Gulf War. JAMA. 1998 Sep 16;280(11):981-8.
- Gray GC, Reed RJ, Kaiser KS, Smith TC, Gastañaga VM. Self-reported symptoms and medical conditions among 11,868 Gulf War-era veterans: the Seabee Health Study. Am J Epidemiol. 2002 Jun 1;155(11):1033-44. Erratum in: Am J Epidemiol. 2005 Feb 1;161(3):302.
- Janssen B, Hohenadel D, Brinkkoetter P, Peters V, Rind N, Fischer C, Rychlik I, Cerna M, Romzova M, de Heer E, Baelde H, Bakker SJ, Zirie M, Rondeau E, Mathieson P, Saleem MA, Meyer J, Köppel H, Sauerhoefer S, Bartram CR, Nawroth P, Hammes HP, Yard BA, Zschocke J, van der Woude FJ. Carnosine as a protective factor in diabetic nephropathy: association with a leucine repeat of the carnosinase gene CNDP1. Diabetes. 2005 Aug;54(8):2320-7.
- 2008-012
- USAMRMC PR# W81XWH-07-1-0618
- HRPO Log No. A-14542.1