Haemodynamics and Function of the Atria in Congenital Heart Disease by Cardiovascular Magnetic Resonance

Sponsor

University Children's Hospital, Zurich (Other)

Overall Status

Unknown status

CT.gov ID

NCT02161471

Collaborator

(none)

Enrollment

Location

134

Duration (Months)

0.4

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study is to determine whether patients with repaired congenital heart disease show differences in size or function of their heart atria compared to normal controls and depending on the nature of their heart disease.

Condition or Disease	Intervention/Treatment	Phase
Coarctation of the Aorta Tetralogy of Fallot Transposition of the Great Arteries

Detailed Description

Atrial function is important for good ventricular filling and function. In patients with impaired cardiac function, atrial contraction is even more important. So far, the size and function of the atria have been assessed two-dimensionally by angiography and by echocardiography. However, these do not allow exact characterization of the volumetric changes of the atria during the cardiac cycle. Recently, cardiac magnetic resonance (CMR) has been used to assess size and function of the left atrium in adults. Little data are available about function and volume of the atria in children and the role of the atria in congenital heart disease (CHD).

The study will recruit patients with CHD (n=40) and normal controls (n=10). The patient group will be composed by patients suffering from the following conditions: coarctation of the aorta (n=10), tetralogy of Fallot (n=10), transposition of the great arteries after atrial switch (Senning procedure) (n=10), transposition of the great arteries after arterial switch operation (n=10).

The study consists of measurements of sizes and function of the right and the left atrium, respectively, by examining three-dimensional volume changes across the heart cycle, and of phase contrast measurements of blood flow across the valves of the heart.

Study Design

Study Type:

Observational

Anticipated Enrollment :

50 participants

Observational Model:

Cohort

Time Perspective:

Prospective

Official Title:

Haemodynamics and Function of the Atria in Patients With Congenital Heart Defects - Pilot Study by Cardiovascular Magnetic Resonance

Study Start Date :

Oct 1, 2009

Anticipated Primary Completion Date :

Nov 1, 2020

Anticipated Study Completion Date :

Dec 1, 2020

Arms and Interventions

Arm	Intervention/Treatment
Aortic coarctation Patients after repair of coarctation of the aorta
Tetralogy of Fallot Patients after repair of tetralogy of Fallot
TGA atrial switch Patients with transposition of the great arteries after atrial switch (Senning procedure)
TGA arterial switch Patients with transposition of the great arteries after arterial switch operation
Normal Normal controls

Outcome Measures

Primary Outcome Measures

Right and left atrial volume [Day of CMR (baseline only, no intervention)]
Measurement of maximal volume (at end of systole), volume before atrial contraction (in late diastole), and minimal volume (at end of diastole) of both atria.

Secondary Outcome Measures

Blood flow across the atrio-ventricular valves [Day of CMR (baseline only, no intervention)]
Phase contrast measurement of blood flow across the atrio-ventricular and the ventriculo-arterial valves, respectively, to serve as an internal validation of total atrial emptying volumes, as well as to contribute maximum early and late diastolic velocities.