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Fetuin A in Hashimoto Thyroiditis

Sponsor
Istanbul Medeniyet University (Other)
Overall Status
Completed
CT.gov ID
NCT01884649
Collaborator
(none)
97
Enrollment
5
Duration (Months)

Study Details

Study Description

Brief Summary

Fetuin-A levels are reported to be low as a negative acute phase reactant in systemical inflammatory situations. Hashimoto thyroiditis is characterized with inflammation. In this study, we hypothesised that the serum fetuin A levels could be found to be low due to inflammation in patients with Hashimoto thyroiditis

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Patients ≥ 20 years of age being followed up at the outpatient clinics of the Internal Medicine Department in Medeniyet University Goztepe Training and Research Hospital and fulfilling the eligibility criteria will be included in the study. Approval of the local ethics committee and informed consent of the participants will be received for the study. The study is conducted in accordance with the Declaration of Helsinki. Demographic characteristics, concomitant diseases, smoking and alcohol drinking habits, concomitant medication usage, anthropometric and biochemistry data of the eligible patients will be recorded. Patient group will consist of patients with newly diagnosed Hashimoto thyroiditis and the control group will consist of healthy volunteers.

    Groups will be compared according to their demographic, an¬thropometric and biochemistry data and serum fetuin-A levels. In order to detect the relationship between the serum fetuin-A levels and clinical features, correlation analyses will be done.

    Study Design

    Study Type:
    Observational [Patient Registry]
    Actual Enrollment :
    97 participants
    Time Perspective:
    Cross-Sectional
    Official Title:
    Fetuin A as a New Marker of Inflammation in Hashimoto Thyroiditis
    Study Start Date :
    May 1, 2012
    Actual Primary Completion Date :
    Oct 1, 2012
    Actual Study Completion Date :
    Oct 1, 2012

    Arms and Interventions

    Arm Intervention/Treatment
    Group of Hashimoto thyroiditis patients
    Healty control group

    Outcome Measures

    Primary Outcome Measures

    1. Comparison of serum fetuin A levels between patients with Hashimoto thyroiditis and healthy subjects [1 day (The blood samples were obtained on the same day participants arrived to outpatient clinics.)]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    20 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:
    • patients newly diagnosed with Hashimoto thyroiditis
    Exclusion Criteria:

    • Acute infection

    • Acute or chronic inflammatory disease

    • Anti-inflammatory treatment (non-steroidal anti-inflammatory, corticosteroids etc.)

    • Hypoxic situations (chronic obstructive pulmonary disease etc.)

    • Severe heart, kidney and liver disease

    • Pregnancy

    • Endocrine disorders

    • Malignancy

    • Usage of drug that affects thyroid hormone levels

    Contacts and Locations

    Locations

    No locations specified.

    Sponsors and Collaborators

    • Istanbul Medeniyet University

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Sevilay Muratli, M.D., Istanbul Medeniyet University
    ClinicalTrials.gov Identifier:
    NCT01884649
    Other Study ID Numbers:
    • GEAH-1
    First Posted:
    Jun 24, 2013
    Last Update Posted:
    Jun 24, 2013
    Last Verified:
    Jun 1, 2013
    Keywords provided by Sevilay Muratli, M.D., Istanbul Medeniyet University
    Acute phase reactant, fetuin A, Hashimoto thyroiditis
    Additional relevant MeSH terms:
    Thyroiditis
    Hashimoto Disease

    Study Results

    No Results Posted as of Jun 24, 2013