Radiation Therapy and Cisplatin in Treating Patients With Advanced Head and Neck Cancer
Sponsor
Radiation Therapy Oncology Group (Other)
Overall Status
Completed
CT.gov ID
NCT00005088
Collaborator
National Cancer Institute (NCI) (NIH)
258
Study Details
Study Description
Brief Summary
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with radiation therapy may kill more tumor cells.
PURPOSE: Phase II trial to study the effectiveness of radiation therapy and cisplatin in treating patients who have advanced head and neck cancer.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 2 |
Detailed Description
OBJECTIVES: I. Determine the rate of local regional recurrence at one year in patients with advanced head and neck cancer treated with boost radiotherapy and cisplatin. II. Determine the feasibility of treatment delivery, patient tolerance, and acute and late toxicities in these patients on this regimen. III. Determine the overall survival, disease free survival, and distant relapse rates of these patients on this regimen.
OUTLINE: Patients receive fractionated radiotherapy 1-2 times daily over 5 consecutive days for 6 weeks, and cisplatin IV over 1-2 hours on days 1 and 22. Patients may undergo salvage surgery if biopsy proven cancer remains more than 3 months after treatment. Patients are followed every 3 months for 2 years, every 6 months for 3 years, then annually until death.
PROJECTED ACCRUAL: A total of 50-56 patients will be accrued for this study within 7 months.
Study Design
Study Type:
Interventional
Primary Purpose:
Treatment
Official Title:
A Phase II Trial of Concomitant Boost Radiation and Concurrent Cisplatin for Advanced Head and Neck Carcinomas
Study Start Date
:
Apr 1, 2000
Actual Primary Completion Date
:
Jan 1, 2002
Outcome Measures
Primary Outcome Measures
Eligibility Criteria
Criteria
Ages Eligible for Study:
0 Years
to 120 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
DISEASE CHARACTERISTICS: Histologically proven squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx Stage III or IV No distant metastases
PATIENT CHARACTERISTICS: Age: Not specified Performance status: Zubrod 0-1 Life expectancy:
At least 6 months Hematopoietic: Absolute granulocyte count at least 2,000/mm3 Platelet count at least 100,000/mm3 Hepatic: Bilirubin no greater than 1.5 mg/dL SGOT or SGPT no greater than 2 times upper limit of normal Renal: Creatinine no greater than 1.5 mg/dL Creatinine clearance at least 50 mL/min Calcium normal Cardiovascular: No symptomatic coronary artery disease No angina No myocardial infarction within the past 6 months Other: Not pregnant or nursing Fertile patients must use effective contraception No other malignancy within the past 3 years except nonmelanomatous skin cancer
PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: No prior chemotherapy Endocrine therapy: Not specified Radiotherapy: No prior radiotherapy to the head and neck Surgery: No initial surgery (except diagnostic biopsy of the primary site or neck)
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University of Alabama Comprehensive Cancer Center | Birmingham | Alabama | United States | 35294 |
| 2 | Comprehensive Cancer Institute of Huntsville | Huntsville | Alabama | United States | 35801 |
| 3 | Huntsville Hospital System | Huntsville | Alabama | United States | 35801 |
| 4 | Mobile Infirmary Medical Center | Mobile | Alabama | United States | 36640-0460 |
| 5 | Urology Associates - Mobile AL | Mobile | Alabama | United States | 36640 |
| 6 | MBCCOP - University of South Alabama | Mobile | Alabama | United States | 36688 |
| 7 | Alabama Oncology, LLC | Montgomery | Alabama | United States | 36106-2801 |
| 8 | Radiation Oncology Associates of West Alabama | Tuscaloosa | Alabama | United States | 35401 |
| 9 | Providence Cancer Therapy Center | Anchorage | Alaska | United States | 99508 |
| 10 | Arizona Cancer Center | Tucson | Arizona | United States | 85724 |
| 11 | Mount Diablo Medical Center | Concord | California | United States | 94524-4110 |
| 12 | California Cancer Center | Fresno | California | United States | 93720 |
| 13 | Saint Agnes Cancer Center | Fresno | California | United States | 93720 |
| 14 | Glendale Memorial Hospital and Health Center | Glendale | California | United States | 91204 |
| 15 | Sutter Health Western Division Cancer Research Group | Greenbrae | California | United States | 94904 |
| 16 | University of California San Diego Cancer Center | La Jolla | California | United States | 92093-0658 |
| 17 | Loma Linda University Medical Center | Loma Linda | California | United States | 92354 |
| 18 | Veterans Affairs Medical Center - Long Beach | Long Beach | California | United States | 90822 |
| 19 | Kaiser Permanente Medical Center - Los Angeles | Los Angeles | California | United States | 90027 |
| 20 | USC/Norris Comprehensive Cancer Center | Los Angeles | California | United States | 90033-0800 |
| 21 | Jonsson Comprehensive Cancer Center, UCLA | Los Angeles | California | United States | 90095-1781 |
| 22 | Beckman Research Institute, City of Hope | Los Angeles | California | United States | 91010 |
| 23 | CCOP - Bay Area Tumor Institute | Oakland | California | United States | 94609-3305 |
| 24 | Cancer Care Center | Pomona | California | United States | 91767 |
| 25 | Radiation Oncology Center - Sacramento | Sacramento | California | United States | 95816 |
| 26 | Radiation Medical Group, Inc. | San Diego | California | United States | 92101-1492 |
| 27 | UCSF Cancer Center and Cancer Research Institute | San Francisco | California | United States | 94115-0128 |
| 28 | O'Connor Hospital | San Jose | California | United States | 95128 |
| 29 | CCOP - Santa Rosa Memorial Hospital | Santa Rosa | California | United States | 95403 |
| 30 | Stanford University | Stanford | California | United States | 94305 |
| 31 | Memorial Hospital Cancer Center | Colorado Springs | Colorado | United States | 80909 |
| 32 | University of Colorado Cancer Center | Denver | Colorado | United States | 80262 |
| 33 | Bridgeport Hospital | Bridgeport | Connecticut | United States | 06610 |
| 34 | Whittingham Cancer Center | Norwalk | Connecticut | United States | 06856 |
| 35 | CCOP - Christiana Care Health Services | Wilmington | Delaware | United States | 19899 |
| 36 | Walter Reed Army Medical Center | Washington | District of Columbia | United States | 20307-5000 |
| 37 | Lykes Center for Radiation Therapy | Clearwater | Florida | United States | 33757-0210 |
| 38 | Halifax Medical Center | Daytona Beach | Florida | United States | 32114 |
| 39 | Radiation Therapy Associates - Fort Myers | Fort Myers | Florida | United States | 33901 |
| 40 | University of Florida Health Science Center | Gainesville | Florida | United States | 32610-0296 |
| 41 | Health First Holmes Regional Medical Center | Melbourne | Florida | United States | 32901 |
| 42 | CCOP - Mount Sinai Medical Center | Miami Beach | Florida | United States | 33140 |
| 43 | Veterans Affairs Medical Center - Miami | Miami | Florida | United States | 33125 |
| 44 | Sylvester Cancer Center, University of Miami | Miami | Florida | United States | 33136 |
| 45 | Baptist Hospital of Miami | Miami | Florida | United States | 33176-2197 |
| 46 | Florida Radiation Oncology Group | Orange Park | Florida | United States | 32073 |
| 47 | MD Anderson Cancer Center Orlando | Orlando | Florida | United States | 32806 |
| 48 | Bay Medical Center | Panama City | Florida | United States | 32401 |
| 49 | Gulf Coast Cancer Treatment Center | Panama City | Florida | United States | 32405-4587 |
| 50 | West Florida Cancer Institute - Pensacola | Pensacola | Florida | United States | 32514 |
| 51 | Bayfront Medical Center | Saint Petersburg | Florida | United States | 33701 |
| 52 | Sarasota Radiation and Medical Oncology Center | Sarasota | Florida | United States | 34233 |
| 53 | Tallahassee Memorial Healthcare | Tallahassee | Florida | United States | 32308 |
| 54 | H. Lee Moffitt Cancer Center and Research Institute | Tampa | Florida | United States | 33612 |
| 55 | Emory University Hospital - Atlanta | Atlanta | Georgia | United States | 30322 |
| 56 | CCOP - Atlanta Regional | Atlanta | Georgia | United States | 30342-1701 |
| 57 | Medical Center/John B. Amos Community Cancer Center | Columbus | Georgia | United States | 31902 |
| 58 | InterCommunity Cancer Center at Rome | Rome | Georgia | United States | 30161 |
| 59 | Northwest Community Hospital | Arlington Heights | Illinois | United States | 60005 |
| 60 | Northwestern Memorial Hospital | Chicago | Illinois | United States | 60611 |
| 61 | University of Chicago Cancer Research Center | Chicago | Illinois | United States | 60637 |
| 62 | CCOP - Central Illinois | Decatur | Illinois | United States | 62526 |
| 63 | Provena St. Joseph Hospital- Regional Cancer Care Center | Elgin | Illinois | United States | 60123 |
| 64 | Ingalls Memorial Hospital | Harvey | Illinois | United States | 60426 |
| 65 | Loyola University Medical Center | Maywood | Illinois | United States | 60153 |
| 66 | Lutheran General Cancer Care Center | Park Ridge | Illinois | United States | 60068 |
| 67 | Methodist Medical Center of Illinois | Peoria | Illinois | United States | 61636 |
| 68 | St. John's Medical Center | Anderson | Indiana | United States | 46016 |
| 69 | Veterans Affairs Medical Center - Indianapolis (Roudebush) | Indianapolis | Indiana | United States | 46202 |
| 70 | Clarion Health Partners Inc. | Indianapolis | Indiana | United States | 46206-1367 |
| 71 | Community Hospitals of Indianapolis - Regional Cancer Center | Indianapolis | Indiana | United States | 46219 |
| 72 | Ball Memorial Hospital | Muncie | Indiana | United States | 47303-3499 |
| 73 | Memorial Hospital of South Bend | South Bend | Indiana | United States | 46601 |
| 74 | St. Joseph's Radiation Oncology Center | South Bend | Indiana | United States | 46617 |
| 75 | Wendt Regional Cancer Center of Finley Hospital | Dubuque | Iowa | United States | 52001 |
| 76 | University of Iowa Hospitals and Clinics | Iowa City | Iowa | United States | 52242 |
| 77 | Veterans Affairs Medical Center - Lexington | Lexington | Kentucky | United States | 40511-1093 |
| 78 | Albert B. Chandler Medical Center, University of Kentucky | Lexington | Kentucky | United States | 40536-0084 |
| 79 | James Graham Brown Cancer Center | Louisville | Kentucky | United States | 40202 |
| 80 | Louisville Radiation Oncology | Louisville | Kentucky | United States | 40215 |
| 81 | Merle M. Mahr Cancer Center | Madisonville | Kentucky | United States | 42431 |
| 82 | Western Baptist Hospital | Paducah | Kentucky | United States | 42001 |
| 83 | Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana | United States | 70809 |
| 84 | Romagosa Radiation Oncology Center | Lafayette | Louisiana | United States | 70501 |
| 85 | MBCCOP - LSU Medical Center | New Orleans | Louisiana | United States | 70112 |
| 86 | Tulane University School of Medicine | New Orleans | Louisiana | United States | 70112 |
| 87 | CCOP - Ochsner | New Orleans | Louisiana | United States | 70121 |
| 88 | Maine Medical Center | Portland | Maine | United States | 04102 |
| 89 | Anne Arundel Oncology Center | Annapolis | Maryland | United States | 21401 |
| 90 | Greater Baltimore Medical Center and Cancer Center | Baltimore | Maryland | United States | 21204 |
| 91 | Harbor Hospital Center | Baltimore | Maryland | United States | 21225 |
| 92 | Sinai Hospital of Baltimore | Baltimore | Maryland | United States | 21225 |
| 93 | Johns Hopkins Oncology Center | Baltimore | Maryland | United States | 21231 |
| 94 | Radiation Oncology Affiliates of Maryland, P.A. | Baltimore | Maryland | United States | 21237 |
| 95 | Peninsula Regional Medical Center | Salisbury | Maryland | United States | 21801 |
| 96 | Cape Cod Hospital | Hyannis | Massachusetts | United States | 02601 |
| 97 | Veterans Affairs Medical Center - Boston (Jamaica Plain) | Jamaica Plain | Massachusetts | United States | 02130 |
| 98 | CCOP - Ann Arbor Regional | Ann Arbor | Michigan | United States | 48106 |
| 99 | University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan | United States | 48109-0752 |
| 100 | Barbara Ann Karmanos Cancer Institute | Detroit | Michigan | United States | 48201 |
| 101 | Henry Ford Hospital | Detroit | Michigan | United States | 48202 |
| 102 | McLaren Regional Cancer Center | Flint | Michigan | United States | 48432 |
| 103 | Hurley Medical Center | Flint | Michigan | United States | 48503 |
| 104 | CCOP - Kalamazoo | Kalamazoo | Michigan | United States | 49007-3731 |
| 105 | Sparrow Regional Cancer Center | Lansing | Michigan | United States | 48909 |
| 106 | Marquette General Hospital | Marquette | Michigan | United States | 49855 |
| 107 | MidMichigan Regional Medical Center | Midland | Michigan | United States | 48670 |
| 108 | William Beaumont Hospital | Royal Oak | Michigan | United States | 48073 |
| 109 | St. Mary's Medical Center | Saginaw | Michigan | United States | 48601 |
| 110 | Mayo Clinic Cancer Center | Rochester | Minnesota | United States | 55905 |
| 111 | CCOP - Metro-Minnesota | Saint Louis Park | Minnesota | United States | 55416 |
| 112 | North Mississippi Medical Center/Cancer Center | Tupelo | Mississippi | United States | 38801 |
| 113 | Ellis Fischel Cancer Center - Columbia | Columbia | Missouri | United States | 65203 |
| 114 | CCOP - Kansas City | Kansas City | Missouri | United States | 64131 |
| 115 | St. Louis University Health Sciences Center | Saint Louis | Missouri | United States | 63110-0250 |
| 116 | Mallinckrodt Institute of Radiology | Saint Louis | Missouri | United States | 63110 |
| 117 | Cancer Research for the Ozarks | Springfield | Missouri | United States | 65807 |
| 118 | CCOP - Cancer Research for the Ozarks | Springfield | Missouri | United States | 65807 |
| 119 | CCOP - Montana Cancer Consortium | Billings | Montana | United States | 59101 |
| 120 | Methodist Cancer Center - Omaha | Omaha | Nebraska | United States | 68114 |
| 121 | Nebraska Health System | Omaha | Nebraska | United States | 68198-7400 |
| 122 | CCOP - Southern Nevada Cancer Research Foundation | Las Vegas | Nevada | United States | 89106 |
| 123 | Norris Cotton Cancer Center | Lebanon | New Hampshire | United States | 03756 |
| 124 | Elliot Regional Cancer Center | Manchester | New Hampshire | United States | 03103 |
| 125 | Veterans Affairs Medical Center - East Orange | East Orange | New Jersey | United States | 07018-1095 |
| 126 | John F. Kennedy Medical Center | Edison | New Jersey | United States | 08818 |
| 127 | Trinitas Hospital - Jersey Street Campus | Elizabeth | New Jersey | United States | 07201 |
| 128 | Monmouth Medical Center | Long Branch | New Jersey | United States | 07740 |
| 129 | South Jersey Hospital - Millville | Millville | New Jersey | United States | 08332 |
| 130 | Fox Chase Cancer Center at Virtua-Memorial Hospital Burlington County | Mount Holly | New Jersey | United States | 08060 |
| 131 | Cancer Institute of New Jersey | New Brunswick | New Jersey | United States | 08901 |
| 132 | Newark Beth Israel Medical Center | Newark | New Jersey | United States | 07112 |
| 133 | Atlantic City Medical Center | Pomona | New Jersey | United States | 08240 |
| 134 | Community Medical Center | Toms River | New Jersey | United States | 08755 |
| 135 | St. Francis Medical Center | Trenton | New Jersey | United States | 08629 |
| 136 | Associated Radiologists, P.A. | Warren | New Jersey | United States | 07059 |
| 137 | Saint Joseph Medical Center | Albuquerque | New Mexico | United States | 87102 |
| 138 | Cancer Center of Albany Medical Center | Albany | New York | United States | 12208 |
| 139 | Albert Einstein Comprehensive Cancer Center | Bronx | New York | United States | 10461 |
| 140 | State University of New York Health Science Center at Brooklyn | Brooklyn | New York | United States | 11203 |
| 141 | New York Methodist Hospital | Brooklyn | New York | United States | 11215-3609 |
| 142 | Roswell Park Cancer Institute | Buffalo | New York | United States | 14263-0001 |
| 143 | Finger Lakes Radiation Oncology, P.C. | Clifton Springs | New York | United States | 14432 |
| 144 | CCOP - North Shore University Hospital | Manhasset | New York | United States | 11030 |
| 145 | Beth Israel Medical Center | New York | New York | United States | 10003 |
| 146 | NYU School of Medicine's Kaplan Comprehensive Cancer Center | New York | New York | United States | 10016 |
| 147 | Memorial Sloan-Kettering Cancer Center | New York | New York | United States | 10021 |
| 148 | Herbert Irving Comprehensive Cancer Center | New York | New York | United States | 10032 |
| 149 | Champlain Valley Physicians Hospital Medical Center | Plattsburgh | New York | United States | 12901 |
| 150 | Vassar Brothers Hospital | Poughkeepsie | New York | United States | 12601 |
| 151 | University of Rochester Cancer Center | Rochester | New York | United States | 14642 |
| 152 | New York Medical College | Valhalla | New York | United States | 10595 |
| 153 | Lineberger Comprehensive Cancer Center, UNC | Chapel Hill | North Carolina | United States | 27599-7295 |
| 154 | Northeast Medical Center | Concord | North Carolina | United States | 28025 |
| 155 | East Carolina University School of Medicine | Greenville | North Carolina | United States | 27858-4354 |
| 156 | Catawba Memorial Hospital | Hickory | North Carolina | United States | 28601 |
| 157 | CCOP - Southeast Cancer Control Consortium | Winston-Salem | North Carolina | United States | 27104-4241 |
| 158 | Comprehensive Cancer Center of Wake Forest University Baptist Medical Center | Winston-Salem | North Carolina | United States | 27157-1082 |
| 159 | Meritcare Roger Maris Cancer Center | Fargo | North Dakota | United States | 58122 |
| 160 | UNIMED Medical Center | Minot | North Dakota | United States | 58701 |
| 161 | Akron General Medical Center | Akron | Ohio | United States | 44302 |
| 162 | Akron City Hospital | Akron | Ohio | United States | 44309 |
| 163 | Christ Hospital | Cincinnati | Ohio | United States | 45219 |
| 164 | Ireland Cancer Center | Cleveland | Ohio | United States | 44106-5065 |
| 165 | University Hospitals of Cleveland | Cleveland | Ohio | United States | 44106 |
| 166 | Cleveland Clinic Cancer Center | Cleveland | Ohio | United States | 44195 |
| 167 | CCOP - Columbus | Columbus | Ohio | United States | 43206 |
| 168 | Arthur G. James Cancer Hospital - Ohio State University | Columbus | Ohio | United States | 43210 |
| 169 | CCOP - Dayton | Kettering | Ohio | United States | 45429 |
| 170 | CCOP - Toledo Community Hospital Oncology Program | Toledo | Ohio | United States | 43623-3456 |
| 171 | St. Anthony Hospital | Oklahoma City | Oklahoma | United States | 73101 |
| 172 | St. John Medical Center | Tulsa | Oklahoma | United States | 74104 |
| 173 | CCOP - Columbia River Program | Portland | Oregon | United States | 97213 |
| 174 | Lehigh Valley Hospital | Allentown | Pennsylvania | United States | 18103 |
| 175 | St. Luke's Hospital Regional Cancer Center | Bethlehem | Pennsylvania | United States | 18015 |
| 176 | Penn State Geisinger Medical Center | Danville | Pennsylvania | United States | 17822-2001 |
| 177 | Mercy Catholic Medical Center, Mercy Fitzgerald Divison | Darby | Pennsylvania | United States | 19023 |
| 178 | Delaware County Memorial Hospital | Drexel Hill | Pennsylvania | United States | 19026 |
| 179 | Penn State Geisinger Cancer Center | Hershey | Pennsylvania | United States | 17033 |
| 180 | Hahnemann University Hospital | Philadelphia | Pennsylvania | United States | 19102-1192 |
| 181 | University of Pennsylvania Cancer Center | Philadelphia | Pennsylvania | United States | 19104 |
| 182 | Veterans Affairs Medical Center - Philadelphia | Philadelphia | Pennsylvania | United States | 19104 |
| 183 | Kimmel Cancer Center of Thomas Jefferson University - Philadelphia | Philadelphia | Pennsylvania | United States | 19107 |
| 184 | Fox Chase Cancer Center | Philadelphia | Pennsylvania | United States | 19111 |
| 185 | Albert Einstein Cancer Center | Philadelphia | Pennsylvania | United States | 19141 |
| 186 | University of Pittsburgh Cancer Institute | Pittsburgh | Pennsylvania | United States | 15213 |
| 187 | Mercy Hospital of Pittsburgh | Pittsburgh | Pennsylvania | United States | 15219 |
| 188 | Western Pennsylvania Hospital | Pittsburgh | Pennsylvania | United States | 15224 |
| 189 | Reading Hospital and Medical Center | Reading | Pennsylvania | United States | 19612-6052 |
| 190 | Mercy Hospital Cancer Center - Scranton | Scranton | Pennsylvania | United States | 18501 |
| 191 | Wilkes Barre General Hospital | Wilkes-Barre | Pennsylvania | United States | 18764 |
| 192 | CCOP - MainLine Health | Wynnewood | Pennsylvania | United States | 19096 |
| 193 | York Hospital | York | Pennsylvania | United States | 17315 |
| 194 | Roger Williams Medical Center/BUSM | Providence | Rhode Island | United States | 02908-4735 |
| 195 | Medical University of South Carolina | Charleston | South Carolina | United States | 29425-0721 |
| 196 | CCOP - Greenville | Greenville | South Carolina | United States | 29615 |
| 197 | CCOP - Upstate Carolina | Spartanburg | South Carolina | United States | 29303 |
| 198 | Rapid City Regional Hospital | Rapid City | South Dakota | United States | 57709 |
| 199 | Jackson-Madison County General Hospital | Jackson | Tennessee | United States | 38301 |
| 200 | Baptist Regional Cancer Center - Knoxville | Knoxville | Tennessee | United States | 37901 |
| 201 | CCOP - Baptist Cancer Institute | Memphis | Tennessee | United States | 38117 |
| 202 | University of Tennessee, Memphis Cancer Center | Memphis | Tennessee | United States | 38163 |
| 203 | Vanderbilt Cancer Center | Nashville | Tennessee | United States | 37232-6838 |
| 204 | Harrington Cancer Center | Amarillo | Texas | United States | 79106 |
| 205 | Julie and Ben Rogers Cancer Institute | Beaumont | Texas | United States | 77701 |
| 206 | University of Texas Medical Branch | Galveston | Texas | United States | 77555-1329 |
| 207 | University of Texas - MD Anderson Cancer Center | Houston | Texas | United States | 77030 |
| 208 | Wilford Hall - 59th Medical Wing | Lackland Air Force Base | Texas | United States | 78236-5300 |
| 209 | Joe Arrington Cancer Research and Treatment Center | Lubbock | Texas | United States | 79410-1894 |
| 210 | Bayshore Medical Center | Pasadena | Texas | United States | 77504 |
| 211 | East Texas Medical Center - Cancer Institute | Tyler | Texas | United States | 75701 |
| 212 | Dixie Regional Medical Center | Saint George | Utah | United States | 84770 |
| 213 | University of Utah Health Sciences Center | Salt Lake City | Utah | United States | 84132 |
| 214 | LDS Hospital | Salt Lake City | Utah | United States | 84143 |
| 215 | CCOP - Southwestern Vermont Regional Cancer Center | Bennington | Vermont | United States | 05201 |
| 216 | Vermont Cancer Center | Burlington | Vermont | United States | 05401-3498 |
| 217 | Martha Jefferson Hospital | Charlottesville | Virginia | United States | 22901 |
| 218 | Cancer Center, University of Virginia HSC | Charlottesville | Virginia | United States | 22908 |
| 219 | RMH Regional Canter Center | Harrisonburg | Virginia | United States | 22801 |
| 220 | Virginia Baptist Hospital | Lynchburg | Virginia | United States | 24503 |
| 221 | Naval Medical Center, Portsmouth | Portsmouth | Virginia | United States | 23708-2197 |
| 222 | Swedish Cancer Institute | Seattle | Washington | United States | 98104 |
| 223 | Virginia Mason Medical Center | Seattle | Washington | United States | 98111 |
| 224 | Deaconess Medical Center | Spokane | Washington | United States | 99210-0248 |
| 225 | Yakima Valley Memorial Hospital | Yakima | Washington | United States | 98902 |
| 226 | Schiffler Cancer Center | Wheeling | West Virginia | United States | 26003 |
| 227 | St. Vincent Hospital | Green Bay | Wisconsin | United States | 54307-3508 |
| 228 | Gundersen Lutheran Medical Foundation | La Crosse | Wisconsin | United States | 54601 |
| 229 | Southern Wisconsin Radiotherapy Center | Madison | Wisconsin | United States | 53713 |
| 230 | University of Wisconsin Comprehensive Cancer Center | Madison | Wisconsin | United States | 53792 |
| 231 | Marshfield Clinic | Marshfield | Wisconsin | United States | 54449 |
| 232 | Community Memorial Hospital | Menomonee Falls | Wisconsin | United States | 53051 |
| 233 | St. Joseph's Hospital | Milwaukee | Wisconsin | United States | 53210 |
| 234 | Columbia Hospital | Milwaukee | Wisconsin | United States | 53211 |
| 235 | St. Luke's Medical Center | Milwaukee | Wisconsin | United States | 53215 |
| 236 | Medical College of Wisconsin | Milwaukee | Wisconsin | United States | 53226 |
| 237 | Veterans Affairs Medical Center - Milwaukee (Zablocki) | Milwaukee | Wisconsin | United States | 53295 |
| 238 | Southeastern Wisconsin Regional Cancer Center | Racine | Wisconsin | United States | 53405 |
| 239 | Waukesha Memorial Hospital | Waukesha | Wisconsin | United States | 53188 |
| 240 | Tom Baker Cancer Center - Calgary | Calgary | Alberta | Canada | T2N 4N2 |
| 241 | Cross Cancer Institute | Edmonton | Alberta | Canada | T6G 1Z2 |
| 242 | BC Cancer Agency | Vancouver | British Columbia | Canada | V5Z 4E6 |
| 243 | Doctor Leon Richard Oncology Centre | Moncton | New Brunswick | Canada | E1C 8X3 |
| 244 | Saint John Regional Hospital | Saint John | New Brunswick | Canada | E2L 4L2 |
| 245 | Dr. H. Bliss Murphy Cancer Centre | St. Johns | Newfoundland and Labrador | Canada | A1B 3V6 |
| 246 | Nova Scotia Cancer Centre | Halifax | Nova Scotia | Canada | B3H 1V7 |
| 247 | Cancer Care Ontario-Hamilton Regional Cancer Centre | Hamilton | Ontario | Canada | L8V 5C2 |
| 248 | Kingston Regional Cancer Centre | Kingston | Ontario | Canada | K7L 5P9 |
| 249 | Cancer Care Ontario-London Regional Cancer Centre | London | Ontario | Canada | N6A 4L6 |
| 250 | Ottawa Regional Cancer Centre - Civic Campus | Ottawa | Ontario | Canada | K1Y 4K7 |
| 251 | Northeastern Ontario Regional Cancer Centre, Sudbury | Sudbury | Ontario | Canada | P3E 5J1 |
| 252 | Northwestern Ontario Regional Cancer Centre, Thunder Bay | Thunder Bay | Ontario | Canada | P7A 7T1 |
| 253 | Toronto Sunnybrook Regional Cancer Centre | Toronto | Ontario | Canada | M4N 3M5 |
| 254 | Princess Margaret Hospital | Toronto | Ontario | Canada | M5G 2M9 |
| 255 | Centre Universitaire de Sante de l'Estrie - Site Fleurimont | Fleurimont | Quebec | Canada | J1H 5N4 |
| 256 | Centre Hospitalier de l'Universite de Montreal | Montreal | Quebec | Canada | H2L-4M1 |
| 257 | McGill University Department of Oncology | Montreal | Quebec | Canada | H2W 1S6 |
| 258 | Saskatoon Cancer Centre | Saskatoon | Saskatchewan | Canada | S7N 4H4 |
Sponsors and Collaborators
- Radiation Therapy Oncology Group
- National Cancer Institute (NCI)
Investigators
- Study Chair: K. Kian Ang, MD, PhD, M.D. Anderson Cancer Center
Study Documents (Full-Text)
None provided.More Information
Publications
- Machtay M, Moughan J, Trotti A, et al.: Pre-treatment and treatment related risk factors for severe late toxicity after chemo-RT for head and neck cancer: an RTOG analysis. [Abstract] J Clin Oncol 24 (Suppl 18): A-5500, 280s, 2006.
- Machtay M, Moughan J, Trotti A, Garden AS, Weber RS, Cooper JS, Forastiere A, Ang KK. Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: an RTOG analysis. J Clin Oncol. 2008 Jul 20;26(21):3582-9. doi: 10.1200/JCO.2007.14.8841. Epub 2008 Jun 16.
- O'Meara EA, Machtay M, Moughan J, et al.: Associations between radiation doses to pharyngeal regions and severe late toxicity in head and neck cancer patients treated with concurrent chemoradiotherapy: an RTOG analysis. [Abstract] Int J Radiat Oncol Biol Phys 69 (3): A-96, S54-5, 2007.
Responsible Party:
Radiation Therapy Oncology Group
ClinicalTrials.gov Identifier:
NCT00005088
Other Study ID Numbers:
- RTOG-9914
- CDR0000067706
First Posted:
May 26, 2004
Last Update Posted:
Oct 22, 2020
Last Verified:
Nov 1, 2013
Keywords provided by Radiation Therapy Oncology Group
Additional relevant MeSH terms: