Biafine Cream to Reduce Side Effects of Radiation Therapy in Patients Receiving Treatment for Advanced Head and Neck Cancer
Sponsor
Radiation Therapy Oncology Group (Other)
Overall Status
Completed
CT.gov ID
NCT00006481
Collaborator
National Cancer Institute (NCI) (NIH)
260
Study Details
Study Description
Brief Summary
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells, but may cause skin irritation and inflammation. Biafine cream may be effective in lessening side effects caused by radiation therapy.
PURPOSE: Randomized phase III trial to determine the effectiveness of Biafine cream in reducing side effects of radiation therapy in patients receiving treatment for head and neck cancer.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 3 |
Detailed Description
OBJECTIVES: I. Compare the efficacy of prophylactic Biafine cream vs standard best supportive care in reducing grade 2 or higher radiation-induced skin toxicity observed during radiotherapy in patients with advanced squamous cell carcinoma of the head and neck. II. Determine if prophylactic or interventional use of Biafine cream is more effective based on a reduction in maximum skin toxicity resulting from radiation treatment in this patient population. III. Compare quality of life of these patients with this treatment. IV. Assess the toxicity of Biafine cream in these patients.
OUTLINE: This is a randomized study. Patients are stratified according to lymph node status (negative vs positive), type of treatment (radiation plus chemotherapy vs radiation alone), radiation fractionation (standard vs concurrent boost), and radiation dose (50-60 Gy vs greater than 60 Gy). Patients are randomized to 1 of 3 treatment arms. Arm I: Patients receive radiotherapy once daily 5 days a week for 5-8 weeks, with or without standard skin cream application (no Biafine cream) to irradiated skin. Arm II: Patients receive radiotherapy as in arm I, with Biafine cream applied to skin 3 times daily 7 days a week at the initiation of radiotherapy and continuing for 2 weeks after the last radiation treatment. Biafine cream is applied no fewer than 4 hours before treatment and no fewer than 4 hours between applications. Arm III: Patients receive radiotherapy as in arms I and II, with Biafine cream applied as in arm II only after skin becomes symptomatic (i.e., redness, dryness, itching, or tenderness). Quality of life is assessed before treatment, weekly during treatment, and then weekly for 4 weeks after treatment completion. Patients are followed weekly for 4 weeks.
PROJECTED ACCRUAL: Approximately 500 patients will be accrued for this study within 17 months.
Study Design
Study Type:
Interventional
Primary Purpose:
Supportive Care
Official Title:
A Phase III Comparison of Biafine to Declared Institutional Preference for Radiation Induced Skin Toxicity in Patients Undergoing Radiation Therapy for Advanced Squamous Cell Carcinomas of the Head and Neck
Study Start Date
:
Oct 1, 2000
Actual Primary Completion Date
:
Aug 1, 2002
Outcome Measures
Primary Outcome Measures
Eligibility Criteria
Criteria
Ages Eligible for Study:
0 Years
to 120 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
DISEASE CHARACTERISTICS: Histologically confirmed stage III or IV squamous cell carcinoma of the head and neck, including: Oral cavity Oropharyngeal Hypopharyngeal Laryngeal Radiotherapy indicated as primary treatment or treatment after primary surgical resection Primary field to receive at least 50 Gy No skin rash, ulceration, or open wound in treatment field No tumor involvement of the skin
PATIENT CHARACTERISTICS: Age: Not specified Performance status: Zubrod 0-1 Life expectancy:
Not specified Hematopoietic: Not specified Hepatic: Not specified Renal: Not specified Other: No known skin allergy or sensitivity to Biafine No inflammatory or connective tissue disorders of the skin No history of mental incompetence, including psychological disorders or drug dependency disorders, that would preclude study compliance
PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: Concurrent chemotherapy allowed Endocrine therapy: Not specified Radiotherapy: See Disease Characteristics No prior radiotherapy to treatment field Surgery: See Disease Characteristics Prior surgery allowed Other: No other concurrent investigational therapy No concurrent participation on other RTOG clinical trials No concurrent amifostine (concurrent pilocarpine allowed)
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University of Alabama at Birmingham Comprehensive Cancer Center | Birmingham | Alabama | United States | 35294-3300 |
| 2 | Huntsville Hospital System | Huntsville | Alabama | United States | 35801-4470 |
| 3 | Comprehensive Cancer Institute of Huntsville | Huntsville | Alabama | United States | 35801 |
| 4 | MBCCOP - Gulf Coast | Mobile | Alabama | United States | 36688 |
| 5 | Alabama Oncology, LLC | Montgomery | Alabama | United States | 36106-2801 |
| 6 | Radiation Oncology Associates of West Alabama | Tuscaloosa | Alabama | United States | 35401 |
| 7 | Providence Alaska Medical Center | Anchorage | Alaska | United States | 99508 |
| 8 | Foundation for Cancer Research and Education | Phoenix | Arizona | United States | 85013 |
| 9 | Arizona Cancer Center | Tucson | Arizona | United States | 85724 |
| 10 | University of Arkansas for Medical Sciences | Little Rock | Arkansas | United States | 72205 |
| 11 | Mount Diablo Medical Center | Concord | California | United States | 94524-4110 |
| 12 | Cancer Center and Beckman Research Institute, City of Hope | Duarte | California | United States | 91010-3000 |
| 13 | California Cancer Center | Fresno | California | United States | 93720 |
| 14 | Saint Agnes Cancer Center | Fresno | California | United States | 93720 |
| 15 | Glendale Memorial Hospital and Health Center | Glendale | California | United States | 91204 |
| 16 | Sutter Health West Cancer Research Group | Greenbrae | California | United States | 94904 |
| 17 | University of California San Diego Cancer Center | La Jolla | California | United States | 92093-0658 |
| 18 | Loma Linda University Medical Center | Loma Linda | California | United States | 92354 |
| 19 | Veterans Affairs Medical Center - Long Beach | Long Beach | California | United States | 90822 |
| 20 | USC/Norris Comprehensive Cancer Center and Hospital | Los Angeles | California | United States | 90033-0804 |
| 21 | Jonsson Comprehensive Cancer Center, UCLA | Los Angeles | California | United States | 90095-1781 |
| 22 | CCOP - Bay Area Tumor Institute | Oakland | California | United States | 94609-3305 |
| 23 | Huntington Cancer Center | Pasadena | California | United States | 91105 |
| 24 | Cancer Care Center | Pomona | California | United States | 91767 |
| 25 | Radiation Oncology Center - Sacramento | Sacramento | California | United States | 95816 |
| 26 | Radiation Medical Group, Inc. | San Diego | California | United States | 92101-1492 |
| 27 | UCSF Cancer Center and Cancer Research Institute | San Francisco | California | United States | 94143-0128 |
| 28 | O'Connor Hospital | San Jose | California | United States | 95128 |
| 29 | CCOP - Santa Rosa Memorial Hospital | Santa Rosa | California | United States | 95403 |
| 30 | David Grant Medical Center | Travis Air Force Base | California | United States | 94535 |
| 31 | Memorial Hospital Cancer Center | Colorado Springs | Colorado | United States | 80909 |
| 32 | University of Colorado Cancer Center | Denver | Colorado | United States | 80010 |
| 33 | Saint Mary's Hospital and Medical Center | Grand Junction | Colorado | United States | 81502 |
| 34 | CCOP - Christiana Care Health Services | Wilmington | Delaware | United States | 19899 |
| 35 | Walter Reed Army Medical Center | Washington | District of Columbia | United States | 20307-5000 |
| 36 | Lykes Center for Radiation Therapy | Clearwater | Florida | United States | 33757-0210 |
| 37 | Halifax Medical Center | Daytona Beach | Florida | United States | 32114 |
| 38 | Radiation Therapy Associates - Fort Myers | Fort Myers | Florida | United States | 33901 |
| 39 | University of Florida Health Science Center | Gainesville | Florida | United States | 32610-0296 |
| 40 | Health First Holmes Regional Medical Center | Melbourne | Florida | United States | 32901 |
| 41 | CCOP - Mount Sinai Medical Center | Miami Beach | Florida | United States | 33140 |
| 42 | Veterans Affairs Medical Center - Miami | Miami | Florida | United States | 33125 |
| 43 | Sylvester Cancer Center, University of Miami | Miami | Florida | United States | 33136 |
| 44 | Baptist Hospital of Miami | Miami | Florida | United States | 33176-2197 |
| 45 | Florida Radiation Oncology Group | Orange Park | Florida | United States | 32073 |
| 46 | MD Anderson Cancer Center Orlando | Orlando | Florida | United States | 32806 |
| 47 | Bay Medical Center | Panama City | Florida | United States | 32401 |
| 48 | Gulf Coast Cancer Treatment Center | Panama City | Florida | United States | 32405-4587 |
| 49 | Sarasota Radiation and Medical Oncology Center | Sarasota | Florida | United States | 34233 |
| 50 | Tallahassee Memorial Healthcare | Tallahassee | Florida | United States | 32308 |
| 51 | H. Lee Moffitt Cancer Center and Research Institute | Tampa | Florida | United States | 33612-9497 |
| 52 | Emory University Hospital - Atlanta | Atlanta | Georgia | United States | 30322 |
| 53 | CCOP - Atlanta Regional | Atlanta | Georgia | United States | 30342-1701 |
| 54 | Medical Center/John B. Amos Community Cancer Center | Columbus | Georgia | United States | 31902 |
| 55 | Regional Radiation Oncology Center at Rome | Rome | Georgia | United States | 30165 |
| 56 | MBCCOP - Hawaii | Honolulu | Hawaii | United States | 96813 |
| 57 | Northwest Community Hospital | Arlington Heights | Illinois | United States | 60005 |
| 58 | Northwestern Memorial Hospital | Chicago | Illinois | United States | 60611 |
| 59 | University of Chicago Cancer Research Center | Chicago | Illinois | United States | 60637-1470 |
| 60 | CCOP - Central Illinois | Decatur | Illinois | United States | 62526 |
| 61 | Provena St. Joseph Hospital- Regional Cancer Care Center | Elgin | Illinois | United States | 60123 |
| 62 | Ingalls Memorial Hospital | Harvey | Illinois | United States | 60426 |
| 63 | Loyola University Medical Center | Maywood | Illinois | United States | 60153 |
| 64 | Lutheran General Cancer Care Center | Park Ridge | Illinois | United States | 60068 |
| 65 | Methodist Medical Center of Illinois | Peoria | Illinois | United States | 61636 |
| 66 | St. John's Medical Center | Anderson | Indiana | United States | 46016 |
| 67 | Bloomington Hospital | Bloomington | Indiana | United States | 47402 |
| 68 | Veterans Affairs Medical Center - Indianapolis (Roudebush) | Indianapolis | Indiana | United States | 46202 |
| 69 | Clarion Health Partners Inc. | Indianapolis | Indiana | United States | 46206-1367 |
| 70 | Community Hospitals of Indianapolis - Regional Cancer Center | Indianapolis | Indiana | United States | 46219 |
| 71 | Ball Memorial Hospital | Muncie | Indiana | United States | 47303-3499 |
| 72 | CCOP - Northern Indiana CR Consortium | South Bend | Indiana | United States | 46601 |
| 73 | Wendt Regional Cancer Center of Finley Hospital | Dubuque | Iowa | United States | 52001 |
| 74 | Holden Comprehensive Cancer Center at The University of Iowa | Iowa City | Iowa | United States | 52242-1009 |
| 75 | Central Baptist Hospital | Lexington | Kentucky | United States | 40503 |
| 76 | Veterans Affairs Medical Center - Lexington | Lexington | Kentucky | United States | 40511-1093 |
| 77 | Albert B. Chandler Medical Center, University of Kentucky | Lexington | Kentucky | United States | 40536-0084 |
| 78 | James Graham Brown Cancer Center | Louisville | Kentucky | United States | 40202 |
| 79 | Louisville Radiation Oncology | Louisville | Kentucky | United States | 40215 |
| 80 | Merle M. Mahr Cancer Center | Madisonville | Kentucky | United States | 42431 |
| 81 | Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana | United States | 70809 |
| 82 | Romagosa Radiation Oncology Center | Lafayette | Louisiana | United States | 70501 |
| 83 | MBCCOP - LSU Health Sciences Center | New Orleans | Louisiana | United States | 70112 |
| 84 | Tulane University School of Medicine | New Orleans | Louisiana | United States | 70112 |
| 85 | CCOP - Ochsner | New Orleans | Louisiana | United States | 70121 |
| 86 | Maine Medical Center | Portland | Maine | United States | 04102 |
| 87 | Anne Arundel Oncology Center | Annapolis | Maryland | United States | 21401 |
| 88 | Greater Baltimore Medical Center and Cancer Center | Baltimore | Maryland | United States | 21204 |
| 89 | Harbor Hospital Center | Baltimore | Maryland | United States | 21225 |
| 90 | Sinai Hospital of Baltimore | Baltimore | Maryland | United States | 21225 |
| 91 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Baltimore | Maryland | United States | 21231-2410 |
| 92 | Radiation Oncology Affiliates of Maryland, P.A. | Baltimore | Maryland | United States | 21237 |
| 93 | Peninsula Regional Medical Center | Salisbury | Maryland | United States | 21801 |
| 94 | Cape Cod Hospital | Hyannis | Massachusetts | United States | 02601 |
| 95 | Veterans Affairs Medical Center - Boston (Jamaica Plain) | Jamaica Plain | Massachusetts | United States | 02130 |
| 96 | CCOP - Ann Arbor Regional | Ann Arbor | Michigan | United States | 48106 |
| 97 | University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan | United States | 48109-0752 |
| 98 | Barbara Ann Karmanos Cancer Institute | Detroit | Michigan | United States | 48201-1379 |
| 99 | Henry Ford Hospital | Detroit | Michigan | United States | 48202 |
| 100 | McLaren Regional Cancer Center | Flint | Michigan | United States | 48432 |
| 101 | Hurley Medical Center | Flint | Michigan | United States | 48503 |
| 102 | CCOP - Kalamazoo | Kalamazoo | Michigan | United States | 49007-3731 |
| 103 | Marquette General Hospital | Marquette | Michigan | United States | 49855 |
| 104 | MidMichigan Medical Center - Midland | Midland | Michigan | United States | 48670 |
| 105 | William Beaumont Hospital | Royal Oak | Michigan | United States | 48073 |
| 106 | St. Mary's Medical Center | Saginaw | Michigan | United States | 48601 |
| 107 | William Beaumont Hospital - Troy | Troy | Michigan | United States | 48098 |
| 108 | Mayo Clinic Cancer Center | Rochester | Minnesota | United States | 55905 |
| 109 | CCOP - Metro-Minnesota | Saint Louis Park | Minnesota | United States | 55416 |
| 110 | North Mississippi Medical Center/Cancer Center | Tupelo | Mississippi | United States | 38801 |
| 111 | Ellis Fischel Cancer Center - Columbia | Columbia | Missouri | United States | 65203 |
| 112 | CCOP - Kansas City | Kansas City | Missouri | United States | 64131 |
| 113 | St. Louis University Health Sciences Center | Saint Louis | Missouri | United States | 63110-0250 |
| 114 | Mallinckrodt Institute of Radiology | Saint Louis | Missouri | United States | 63110 |
| 115 | Cancer Research for the Ozarks | Springfield | Missouri | United States | 65807 |
| 116 | CCOP - Cancer Research for the Ozarks | Springfield | Missouri | United States | 65807 |
| 117 | CCOP - Montana Cancer Consortium | Billings | Montana | United States | 59101 |
| 118 | Nebraska Health System | Omaha | Nebraska | United States | 68105-1018 |
| 119 | Methodist Cancer Center - Omaha | Omaha | Nebraska | United States | 68114 |
| 120 | CCOP - Southern Nevada Cancer Research Foundation | Las Vegas | Nevada | United States | 89106 |
| 121 | Norris Cotton Cancer Center | Lebanon | New Hampshire | United States | 03756-0002 |
| 122 | Elliot Regional Cancer Center | Manchester | New Hampshire | United States | 03103 |
| 123 | Veterans Affairs Medical Center - East Orange | East Orange | New Jersey | United States | 07018-1095 |
| 124 | John F. Kennedy Medical Center | Edison | New Jersey | United States | 08818 |
| 125 | Trinitas Hospital - Jersey Street Campus | Elizabeth | New Jersey | United States | 07201 |
| 126 | Monmouth Medical Center | Long Branch | New Jersey | United States | 07740-6395 |
| 127 | South Jersey Regional Cancer Center | Millville | New Jersey | United States | 08332 |
| 128 | Fox Chase Cancer Center at Virtua Memorial Hospital Burlington County | Mount Holly | New Jersey | United States | 08060 |
| 129 | Cancer Institute of New Jersey | New Brunswick | New Jersey | United States | 08901 |
| 130 | Newark Beth Israel Medical Center | Newark | New Jersey | United States | 07112 |
| 131 | Atlantic City Medical Center | Pomona | New Jersey | United States | 08240 |
| 132 | Valley Hospital | Ridgewood | New Jersey | United States | 07450 |
| 133 | Community Medical Center | Toms River | New Jersey | United States | 08755 |
| 134 | St. Francis Medical Center | Trenton | New Jersey | United States | 08629 |
| 135 | Associated Radiologists, P.A. | Warren | New Jersey | United States | 07059 |
| 136 | Saint Joseph Medical Center | Albuquerque | New Mexico | United States | 87102 |
| 137 | Cancer Center of Albany Medical Center | Albany | New York | United States | 12208 |
| 138 | Albert Einstein Comprehensive Cancer Center | Bronx | New York | United States | 10461 |
| 139 | State University of New York Health Science Center at Brooklyn | Brooklyn | New York | United States | 11203 |
| 140 | New York Methodist Hospital | Brooklyn | New York | United States | 11215-3609 |
| 141 | Roswell Park Cancer Institute | Buffalo | New York | United States | 14263-0001 |
| 142 | Finger Lakes Radiation Oncology, P.C. | Clifton Springs | New York | United States | 14432 |
| 143 | CCOP - North Shore University Hospital | Manhasset | New York | United States | 11030 |
| 144 | Beth Israel Medical Center | New York | New York | United States | 10003 |
| 145 | Memorial Sloan-Kettering Cancer Center | New York | New York | United States | 10021 |
| 146 | Herbert Irving Comprehensive Cancer Center | New York | New York | United States | 10032 |
| 147 | Champlain Valley Physicians Hospital Medical Center | Plattsburgh | New York | United States | 12901 |
| 148 | Vassar Brothers Hospital | Poughkeepsie | New York | United States | 12601 |
| 149 | University of Rochester Cancer Center | Rochester | New York | United States | 14642 |
| 150 | CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C. | Syracuse | New York | United States | 13217 |
| 151 | New York Medical College | Valhalla | New York | United States | 10595 |
| 152 | Riverhill Radiation Oncology | Yonkers | New York | United States | 10701 |
| 153 | Lineberger Comprehensive Cancer Center, UNC | Chapel Hill | North Carolina | United States | 27599-7295 |
| 154 | Northeast Medical Center | Concord | North Carolina | United States | 28025 |
| 155 | East Carolina University School of Medicine | Greenville | North Carolina | United States | 27858-4354 |
| 156 | Catawba Memorial Hospital | Hickory | North Carolina | United States | 28601 |
| 157 | CCOP - Southeast Cancer Control Consortium | Winston-Salem | North Carolina | United States | 27104-4241 |
| 158 | Comprehensive Cancer Center at Wake Forest University | Winston-Salem | North Carolina | United States | 27157-1082 |
| 159 | Meritcare Roger Maris Cancer Center | Fargo | North Dakota | United States | 58122 |
| 160 | Trinity Cancer Care Center | Minot | North Dakota | United States | 58701 |
| 161 | Akron General Medical Center | Akron | Ohio | United States | 44302 |
| 162 | Akron City Hospital | Akron | Ohio | United States | 44309 |
| 163 | Barrett Cancer Center, The University Hospital | Cincinnati | Ohio | United States | 45219 |
| 164 | Christ Hospital | Cincinnati | Ohio | United States | 45219 |
| 165 | Ireland Cancer Center | Cleveland | Ohio | United States | 44106-5065 |
| 166 | University Hospitals of Cleveland | Cleveland | Ohio | United States | 44106 |
| 167 | Cleveland Clinic Taussig Cancer Center | Cleveland | Ohio | United States | 44195 |
| 168 | CCOP - Columbus | Columbus | Ohio | United States | 43206 |
| 169 | Arthur G. James Cancer Hospital - Ohio State University | Columbus | Ohio | United States | 43210-1240 |
| 170 | CCOP - Dayton | Kettering | Ohio | United States | 45429 |
| 171 | CCOP - Toledo Community Hospital Oncology Program | Toledo | Ohio | United States | 43623-3456 |
| 172 | St. Anthony Hospital | Oklahoma City | Oklahoma | United States | 73101 |
| 173 | Oklahoma University Medical Center | Oklahoma City | Oklahoma | United States | 73104 |
| 174 | St. John Health System | Tulsa | Oklahoma | United States | 74104 |
| 175 | CCOP - Columbia River Program | Portland | Oregon | United States | 97213 |
| 176 | Lehigh Valley Hospital | Allentown | Pennsylvania | United States | 18103 |
| 177 | St. Luke's Hospital Regional Cancer Center | Bethlehem | Pennsylvania | United States | 18015 |
| 178 | Geisinger Medical Center | Danville | Pennsylvania | United States | 17822-2001 |
| 179 | Fitzgerald Mercy Hospital | Darby | Pennsylvania | United States | 19023 |
| 180 | Delaware County Memorial Hospital | Drexel Hill | Pennsylvania | United States | 19026 |
| 181 | Pocono Cancer Center | East Stroudsburg | Pennsylvania | United States | 18301 |
| 182 | Penn State Geisinger Cancer Center | Hershey | Pennsylvania | United States | 17033 |
| 183 | Hahnemann University Hospital | Philadelphia | Pennsylvania | United States | 19102-1192 |
| 184 | University of Pennsylvania Cancer Center | Philadelphia | Pennsylvania | United States | 19104-4283 |
| 185 | Veterans Affairs Medical Center - Philadelphia | Philadelphia | Pennsylvania | United States | 19104 |
| 186 | Kimmel Cancer Center of Thomas Jefferson University - Philadelphia | Philadelphia | Pennsylvania | United States | 19107-5541 |
| 187 | Fox Chase Cancer Center | Philadelphia | Pennsylvania | United States | 19111 |
| 188 | Albert Einstein Cancer Center | Philadelphia | Pennsylvania | United States | 19141 |
| 189 | University of Pittsburgh Cancer Institute | Pittsburgh | Pennsylvania | United States | 15213-3489 |
| 190 | Mercy Hospital of Pittsburgh | Pittsburgh | Pennsylvania | United States | 15219 |
| 191 | Western Pennsylvania Hospital | Pittsburgh | Pennsylvania | United States | 15224 |
| 192 | Reading Hospital and Medical Center | Reading | Pennsylvania | United States | 19612-6052 |
| 193 | Mercy Hospital Cancer Center - Scranton | Scranton | Pennsylvania | United States | 18501 |
| 194 | Grand View Hospital | Sellersville | Pennsylvania | United States | 18960 |
| 195 | Wilkes Barre General Hospital | Wilkes-Barre | Pennsylvania | United States | 18764 |
| 196 | CCOP - MainLine Health | Wynnewood | Pennsylvania | United States | 19096 |
| 197 | York Hospital | York | Pennsylvania | United States | 17315 |
| 198 | Roger Williams Medical Center/BUSM | Providence | Rhode Island | United States | 02908-4735 |
| 199 | Medical University of South Carolina | Charleston | South Carolina | United States | 29425-0721 |
| 200 | CCOP - Greenville | Greenville | South Carolina | United States | 29615 |
| 201 | CCOP - Upstate Carolina | Spartanburg | South Carolina | United States | 29303 |
| 202 | Rapid City Regional Hospital | Rapid City | South Dakota | United States | 57709 |
| 203 | Jackson-Madison County General Hospital | Jackson | Tennessee | United States | 38301 |
| 204 | University of Tennessee, Memphis Cancer Center | Memphis | Tennessee | United States | 38103 |
| 205 | Vanderbilt-Ingram Cancer Center | Nashville | Tennessee | United States | 37232-6838 |
| 206 | Harrington Cancer Center | Amarillo | Texas | United States | 79106 |
| 207 | Julie and Ben Rogers Cancer Institute | Beaumont | Texas | United States | 77701 |
| 208 | University of Texas Medical Branch | Galveston | Texas | United States | 77555-0209 |
| 209 | University of Texas - MD Anderson Cancer Center | Houston | Texas | United States | 77030-4009 |
| 210 | Wilford Hall - 59th Medical Wing | Lackland Air Force Base | Texas | United States | 78236-5300 |
| 211 | Joe Arrington Cancer Research and Treatment Center | Lubbock | Texas | United States | 79410-1894 |
| 212 | East Texas Medical Center - Cancer Institute | Tyler | Texas | United States | 75701 |
| 213 | Dixie Regional Medical Center | Saint George | Utah | United States | 84770 |
| 214 | University of Utah Health Sciences Center | Salt Lake City | Utah | United States | 84132 |
| 215 | LDS Hospital | Salt Lake City | Utah | United States | 84143 |
| 216 | CCOP - Southwestern Vermont Regional Cancer Center | Bennington | Vermont | United States | 05201 |
| 217 | Vermont Cancer Center | Burlington | Vermont | United States | 05401-3498 |
| 218 | Martha Jefferson Hospital | Charlottesville | Virginia | United States | 22901 |
| 219 | Cancer Center at the University of Virginia | Charlottesville | Virginia | United States | 22908 |
| 220 | RMH Regional Canter Center | Harrisonburg | Virginia | United States | 22801 |
| 221 | Naval Medical Center, Portsmouth | Portsmouth | Virginia | United States | 23708-2197 |
| 222 | Bon-Secours - St. Mary's Hospital | Richmond | Virginia | United States | 23226 |
| 223 | Massey Cancer Center | Richmond | Virginia | United States | 23298-0037 |
| 224 | Virginia Mason Medical Center | Seattle | Washington | United States | 98111 |
| 225 | Deaconess Medical Center | Spokane | Washington | United States | 99210-0248 |
| 226 | Yakima Valley Memorial Hospital | Yakima | Washington | United States | 98902 |
| 227 | Schiffler Cancer Center | Wheeling | West Virginia | United States | 26003 |
| 228 | St. Vincent Hospital | Green Bay | Wisconsin | United States | 54307-3508 |
| 229 | Gundersen Lutheran Medical Foundation | La Crosse | Wisconsin | United States | 54601 |
| 230 | Southern Wisconsin Radiotherapy Center | Madison | Wisconsin | United States | 53713 |
| 231 | University of Wisconsin Comprehensive Cancer Center | Madison | Wisconsin | United States | 53792-6164 |
| 232 | Marshfield Clinic | Marshfield | Wisconsin | United States | 54449 |
| 233 | Community Memorial Hospital | Menomonee Falls | Wisconsin | United States | 53051 |
| 234 | St. Joseph's Hospital | Milwaukee | Wisconsin | United States | 53210 |
| 235 | Columbia Hospital | Milwaukee | Wisconsin | United States | 53211 |
| 236 | St. Luke's Medical Center | Milwaukee | Wisconsin | United States | 53215 |
| 237 | Medical College of Wisconsin | Milwaukee | Wisconsin | United States | 53226 |
| 238 | Veterans Affairs Medical Center - Milwaukee (Zablocki) | Milwaukee | Wisconsin | United States | 53295 |
| 239 | Southeastern Wisconsin Regional Cancer Center | Racine | Wisconsin | United States | 53405 |
| 240 | Waukesha Memorial Hospital | Waukesha | Wisconsin | United States | 53188 |
| 241 | Tom Baker Cancer Center - Calgary | Calgary | Alberta | Canada | T2N 4N2 |
| 242 | Cross Cancer Institute | Edmonton | Alberta | Canada | T6G 1Z2 |
| 243 | British Columbia Cancer Agency | Vancouver | British Columbia | Canada | V5Z 4E6 |
| 244 | Saint John Regional Hospital | Saint John | New Brunswick | Canada | E2L 4L2 |
| 245 | Newfoundland Cancer Treatment and Research Foundation | St. Johns | Newfoundland and Labrador | Canada | A1B 3V6 |
| 246 | Nova Scotia Cancer Centre | Halifax | Nova Scotia | Canada | B3H 1V7 |
| 247 | Cancer Care Ontario-Hamilton Regional Cancer Centre | Hamilton | Ontario | Canada | L8V 5C2 |
| 248 | Kingston Regional Cancer Centre | Kingston | Ontario | Canada | K7L 5P9 |
| 249 | Cancer Care Ontario-London Regional Cancer Centre | London | Ontario | Canada | N6A 4L6 |
| 250 | Ottawa Regional Cancer Centre - General Campus | Ottawa | Ontario | Canada | K1H 1C4 |
| 251 | Northeastern Ontario Regional Cancer Centre, Sudbury | Sudbury | Ontario | Canada | P3E 5J1 |
| 252 | Northwestern Ontario Regional Cancer Centre, Thunder Bay | Thunder Bay | Ontario | Canada | P7A 7T1 |
| 253 | Toronto Sunnybrook Regional Cancer Centre | Toronto | Ontario | Canada | M4N 3M5 |
| 254 | Princess Margaret Hospital | Toronto | Ontario | Canada | M5G 2M9 |
| 255 | CHUS-Hopital Fleurimont | Fleurimont | Quebec | Canada | J1H 5N4 |
| 256 | Centre Hospitalier de l'Universite de Montreal | Montreal | Quebec | Canada | H2L-4M1 |
| 257 | McGill University | Montreal | Quebec | Canada | H2W 1S6 |
| 258 | Centre Hospitalier Universitaire de Quebec | Quebec City | Quebec | Canada | G1R 2J6 |
| 259 | Allan Blair Cancer Centre | Regina | Saskatchewan | Canada | S4T 7T1 |
| 260 | Saskatoon Cancer Centre | Saskatoon | Saskatchewan | Canada | S7N 4H4 |
Sponsors and Collaborators
- Radiation Therapy Oncology Group
- National Cancer Institute (NCI)
Investigators
- Study Chair: Elizabeth Elliott, MRT(T), MRT(R), CCRP, Margaret and Charles Juravinski Cancer Centre
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
Radiation Therapy Oncology Group
ClinicalTrials.gov Identifier:
NCT00006481
Other Study ID Numbers:
- RTOG-9913
- CDR0000068312
- NCI-P00-0173
First Posted:
Dec 31, 2003
Last Update Posted:
Oct 22, 2020
Last Verified:
Nov 1, 2013
Keywords provided by Radiation Therapy Oncology Group
Additional relevant MeSH terms: