Carotid PET/MRI With DOTATATE in Patients Post Head and Neck Radiation Therapy
Study Details
Study Description
Brief Summary
The improvement of comprehensive multi-modality treatment and radiotherapy (RT) technology has resulted in an improved survival rate of head and neck malignancies within recent decades. As survival increases, late toxicity from cancer therapy becomes a larger burden. Radiation induced vascular injury following RT is a recognized complication of radiotherapy. Diagnosis of vascular changes predominately relies on non-invasive imaging techniques. Doppler ultrasound assessment has been proven as a good indicator of diffuse atherosclerotic disease and a significant predictor of future vascular events. New opportunities are provided by the recent introduction of the hybrid PET/MRI scanners for investigating the synergistic effect of these two modalities without the challenge of image co-registration. It has been shown that the PET system integrated with the MRI scanner performs the same as the PET portion of a PET/CT for various cancers and cardiovascular indications. MRI allows better delineation of the carotid artery and atherosclerotic plaque when compared with CT due to the superior soft tissue contrast. The PET/MRI system acquires the PET and MRI simultaneously allowing for perfect alignment between the 2 sets of images, when compared with the sequential acquisition in PET/CT where minor head movements can cause misalignment. There is evidence in the literature that 68-Ga DOTA-TATE PET-imaging can serve as a surrogate marker for evidence of invasion into the vessel wall and thereby possibly detects early, developing atherosclerotic plaque. Thus, combined PET and MR with 68-Ga DOTA-TATE should be a promising imaging tool to screen and characterize patients at risk for radiation induced carotid injury.
In this study, DOTATATE-PET/MR will be performed in up to 60 patients with a history of radiation therapy for head and neck squamous cell carcinoma over 2 years.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Other: PET/MRI scan with 68Ga DOTATATE PET/MRI scan with 68Ga DOTATATE of carotid arteries in in patients following head and neck radiation therapy |
Diagnostic Test: PET/MRI of carotid arteries with 68Ga DOTATATE
PET/MRI of carotid arteries with 68Ga DOTATATE in patients post head and neck radiation therapy
|
Outcome Measures
Primary Outcome Measures
- Validity of PET/MRI with 68Ga DOTATATE of carotid arteries [complete of enrollment, an average of two years]
Macrophage activity detected by 68Ga DOTATATE PET/MRI of carotid arteries in patients at risk for vascular events post radiation of head and neck squamous cell carcinoma.
Eligibility Criteria
Criteria
Inclusion Criteria:
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previously treated with radiation for head and neck malignancy;
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Age Group: ≥30 years;
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Patients who have no contraindications to PET/MRI;
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No allergy to contrast agents.
Exclusion Criteria:
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Pregnant females;
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Age group: < 30 years;
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Allergy to MR contrast agents;
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Pacemakers/ICD/Claustrophobic patients.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University Health Network | Toronto | Ontario | Canada | M5G 2M9 |
Sponsors and Collaborators
- University Health Network, Toronto
Investigators
- Principal Investigator: Patrick Veit-Haibach, MD, University Health Network, Toronto
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 18-6313