LitmusMagnet: Effect of β-alanine Supplementation on Muscle Carnosine

• Sponsor: Nestlé (Industry)
• Overall Status: Completed
• CT.gov ID: NCT00813553
• Collaborator: University of Bern (Other), University Hospital Inselspital, Berne (Other)
• Enrollment: 30
• Location: 1
• Arms: 3
• Duration (Months): 10
• Patients Per Site Per Month: 3

Study Details

Study Description

Brief Summary

Carnosine is a natural acid buffering substance of muscle. The primary objective of this study is to test whether a nutritional supplement of beta-alanine enhances carnosine content in muscle.

Condition or Disease	Intervention/Treatment	Phase
Healthy	Dietary Supplement: placebo; Dietary Supplement: beta-alanine; Dietary Supplement: beta-alanine	N/A

Detailed Description

Volunteers will be randomized to receiving 3 nutritional supplements. Two supplements contain beta-alanine at different doses, the third supplement is a placebo.

Study Design

• Study Type: Interventional
• Anticipated Enrollment: 30 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
• Official Title: Effect of Two 8-week β-alanine Supplementation Protocols on Muscle Carnosine
• Study Start Date: Dec 1, 2008
• Actual Primary Completion Date: Oct 1, 2009
• Actual Study Completion Date: Oct 1, 2009

Arms and Interventions

Arm	Intervention/Treatment
Placebo Comparator: beta-alanine 0	Dietary Supplement: placebo; daily
Experimental: beta-alanine 1	Dietary Supplement: beta-alanine; daily
Experimental: beta-alanine 2	Dietary Supplement: beta-alanine; daily

Outcome Measures

Primary Outcome Measures

1. muscle carnosine concentration [0 to 8 weeks]

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 40 Years
• Sexes Eligible for Study: Male
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• Stable health as evaluated by medical evaluation

• Body mass index higher than 18 kg/m2

• Body mass index lower than 25 kg/m2, unless body fat is less than 20%

Exclusion Criteria:

• intolerance to β-alanine,

• allergy to soy, fish and crustacean

• participation in another intervention study

• consumer of dietary supplement susceptible to contain beta-alanine

• determined to have very high baseline muscle carnosine concentration

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	University and Inselspital	Bern		Switzerland	3010

Sponsors and Collaborators

• Nestlé
• University of Bern
• University Hospital Inselspital, Berne

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Nestlé
• ClinicalTrials.gov Identifier: NCT00813553
• Other Study ID Numbers: 08.13.PER
• First Posted: Dec 23, 2008
• Last Update Posted: Apr 25, 2012
• Last Verified: Apr 1, 2012

• Keywords provided by Nestlé: physical fitness; exercise; amino acid

Study Results

No Results Posted as of Apr 25, 2012