MEDITATION: Brain and Mindfulness
Study Details
Study Description
Brief Summary
The main aim of this project is to explore the neuro-anatomical and -physiological correlates of meditation on attention and emotion-regulation. By investigating this, our scientific goal is to more generally identify the mechanisms and biomarkers of health and mental well-being. Therefore, the investigators use non-invasive imaging like Magneto-EncephaloGraphy (MEG), ElectroEncephaloGraphy (EEG), functional and anatomic Magnetic Resonance Imaging (MRI; including Diffusion tensor - DTI). These brain measures will then be linked to behavioral measurements. Experimental methods (i.e., simple computer tasks) will be used to measure attention, conscious perception and regulation of pain and emotion.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Other: 1. Participants without meditation experience Novices. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience. |
Other: Magneto-encephalography (MEG)
Magneto-encephalography
Other: Electro-encephalography (EEG)
Electro-encephalography
Other: Functional Magnetic Resonance Imaging (fMRI)
Functional Magnetic Resonance Imaging
Other: Anatomical Magnetic Resonance Imaging (aMRI)
Anatomical Magnetic Resonance Imaging
Other: Meditation
Meditation
|
| Other: 2. Participant with a significant meditation experience Experts : > 5000 hours of practice during their life. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience. |
Other: Magneto-encephalography (MEG)
Magneto-encephalography
Other: Electro-encephalography (EEG)
Electro-encephalography
Other: Functional Magnetic Resonance Imaging (fMRI)
Functional Magnetic Resonance Imaging
Other: Anatomical Magnetic Resonance Imaging (aMRI)
Anatomical Magnetic Resonance Imaging
Other: Meditation
Meditation
|
| Other: 3. Participants without meditation experience Novices. There is no meditation intervention during the study but the investigators investigate the effects of meditation by comparing 2 groups who differ in their life time meditation experience (i.e., novices vs. experts). |
Other: Magneto-encephalography (MEG)
Magneto-encephalography
Other: Electro-encephalography (EEG)
Electro-encephalography
Other: Functional Magnetic Resonance Imaging (fMRI)
Functional Magnetic Resonance Imaging
Other: Anatomical Magnetic Resonance Imaging (aMRI)
Anatomical Magnetic Resonance Imaging
|
| Other: 4. Participant with a significant meditation experience Experts : > 5000 hours of practice during their life. There is no meditation intervention during the study but the investigators investigate the effects of meditation by comparing 2 groups who differ in their life time meditation experience (i.e., novices vs. experts). |
Other: Magneto-encephalography (MEG)
Magneto-encephalography
Other: Electro-encephalography (EEG)
Electro-encephalography
Other: Functional Magnetic Resonance Imaging (fMRI)
Functional Magnetic Resonance Imaging
Other: Anatomical Magnetic Resonance Imaging (aMRI)
Anatomical Magnetic Resonance Imaging
|
Outcome Measures
Primary Outcome Measures
- Anatomical MRI scan [Day 1]
Brain structure
- Functional MRI scan [Day1]
Brain activation: Haemodynamic response - BOLD signal.
- EEG [Day 1]
Event-related potential fields : amplitude in fT and latency in ms. Oscillations : power spectral density and time-frequency oscillations in fT^2/Hz
Secondary Outcome Measures
- Behavioral measure : Accuracy of the performed task actions [Day 1]
Participants will perform behavioral computer tasks in which accuracy and speed is important. Performance behavior will be measured in this task: Accuracy of the performed task actions: number of errors and hits
- Psychophysics: Pain threshold [Day 1]
Pain threshold: The threshold of pain or pain threshold is the point along a curve of increasing perception of a stimulus at which pain begins to be felt. The temperature in degrees Celcius at which heat becomes painful for a recipient.
- Psychophysiology : Respiration [Day 1]
Respiration rate: breaths/minute
- Subjective experience of the participant [Day 1]
- Studies biomarkers of inflammation [Day 1]
area of the inflamed site in mm^2, obtained by automatic image processing of a photography
- Behavioral measure : Speed of the performed task actions [Day 1]
Participants will perform behavioral computer tasks in which accuracy and speed is important. Performance behavior will be measured in this task: Speed of the performed task actions: in ms.
- Psychophysiology : Heart [Day 1]
Heart Rate: pulses/minute
- Psychophysiology : Heart rate variability [Day 1]
Heart rate variability (HRV): Using an electrocardiogram, the variation in the beat-to-beat interval; measured in ms.
- Psychophysiology : Muscles [Day 1]
Electromyography (EMG): Recording the electrical activity produced by muscles; measured in mV.
- Psychophysiology : Eyes [Day 1]
Eye gaze position: relative to center of the screen, in imm
- Psychophysiology : Pupillar response [Day 1]
Pupillar response: pupil diameter, in mm.
- Electrogastrogram [Day 1]
Recording the electrical signals that travel through the stomach muscles and control the muscles' contractions (waves/minute)
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Age : 25-70
-
Being affiliated to a social security system.
-
Motivated to participate in this study.
Exclusion Criteria:
-
Medication acting on the central nervous system
-
Opioids, Antidepressive Agents.
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Actual or previous neurological or psychiatric illnesses
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Chronic pain or any other medical condition which is related to pain or an increased sensitivity to pain.
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Not having a personal or family history of epilepsy
-
Alcohol or drugs consumption 2 days before or during the study.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Le Vinatier | Bron | France | 69500 |
Sponsors and Collaborators
- Hospices Civils de Lyon
Investigators
- Principal Investigator: Sandrine SONIE, MD, Le Vinatier
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 69HCL16_0678