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MEM_MOD: Spectral Characteristics of Memory Transformation

Sponsor
Medical University of South Carolina (Other)
Overall Status
Recruiting
CT.gov ID
NCT05946616
Collaborator
(none)
30
Enrollment
1
Location
2
Arms
9
Anticipated Duration (Months)
3.3
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Sometimes, it is necessary to re-learn a previously learned movement behavior, for example, a bad posture during the golf drive or while playing the piano. Unlearning or relearning an intensively trained behavior is particularly important if the behavior is hampering recovery, for example, in chronic pain or after a stroke. With this pilot study, the brain mechanisms that control the change of pre-existing stable memories of a motor skill will be tested with electroencephalography (EEG). Non-invasive brain stimulation will be used to modulate these brain mechanisms and test if it is possible to change the pre-existing motor memory and the learning of a new motor skill.

Condition or Disease Intervention/Treatment Phase
  • Other: Transcranial alternating current stimulation (tACS) combined with behavioral intervention
  • Other: Inactive (sham) stimulation combined with behavioral intervention
 N/A

Study Design

Study Type:
Interventional
Anticipated Enrollment :
30 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
Single (Participant)
Primary Purpose:
Basic Science
Official Title:
Probing Mechanisms of Procedural Memory Transformation With Cross-frequency Transcranial Alternating Current Stimulation (Cf-tACS) as an Avenue to Sculpt Sensorimotor Behavior
Actual Study Start Date :
Jul 1, 2023
Anticipated Primary Completion Date :
Mar 31, 2024
Anticipated Study Completion Date :
Mar 31, 2024

Arms and Interventions

Arm Intervention/Treatment
Experimental: Active non-invasive brain stimulation during behavioral memory interference

Non-invasive brain stimulation with transcranial alternating current stimulation will be applied during a memory interference intervention.

Other: Transcranial alternating current stimulation (tACS) combined with behavioral intervention
Transcranial alternating current stimulation (tACS) combined with behavioral intervention (memory interference).
Sham Comparator: Sham stimulation during behavioral memory interference

Inactive (sham) stimulation will be applied during a memory interference intervention.

Other: Inactive (sham) stimulation combined with behavioral intervention
Inactive (sham) stimulation combined with behavioral intervention (memory interference)

Outcome Measures

Primary Outcome Measures

  1. Behavioral: interference rate [before - after one single intervention (1 hour)]

    Change in performance precision of a previously learned sensorimotor skill

  2. Neural: brain connectivity change [before - after one single intervention (1 hour)]

    Change in EEG-derived markers of brain activation and connectivity

Secondary Outcome Measures

  1. Behavioral: interference rate [before - after one single intervention (24 hour follow-up)]

    Change in performance precision of a previously learned sensorimotor skill

  2. Neural: brain connectivity change [before - after one single intervention (24 hour follow-up)]

    Change in EEG-derived markers of brain activation and connectivity

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:

  • Age 18 years or older (2/3 of the final sample will be ≥60years of age)

  • No previous stroke, brain tumor, neurodegenerative disease, or trauma to the head

  • Ability to give consent for study participation

  • who have access to a personal computer with internet

Exclusion Criteria:

  • • Pregnancy

  • Inability to use all ten fingers to type on a standard computer keyboard

  • Uncorrected vision, hindering perception of visual cues presented on a standard computer screen

  • Medication use at the time of study that may interfere with learning or the effect of tACS, including but not limited to carbamazepine, flunarizine, sulpiride, rivastigmine, dextromethorphan;

  • Neuromuscular disorders affecting hand and finger movements necessary for 10-finger keyboard typing

  • Presence of neurological or psychiatric disorders

  • Presence of scalp injury or disease

  • Prior history of seizures

  • Prior intracranial surgery

  • Prior brain radiotherapy

  • Prior history of intracranial tumor, intracranial infection, or cerebrovascular malformation

  • Metal in head or neck

  • Contraindications to MRI (such as severe claustrophobia, implanted medical devices)

Contacts and Locations

Locations

Site City State Country Postal Code
1 Medical University of South Carolina Charleston South Carolina United States 29425

Sponsors and Collaborators

  • Medical University of South Carolina

Investigators

  • Principal Investigator: Kirstin-Friederike Heise, PhD, Medical University of South Carolina

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Kirstin-Friederike Heise, PhD, Assistant Professor-Faculty, Medical University of South Carolina
ClinicalTrials.gov Identifier:
NCT05946616
Other Study ID Numbers:
  • 00126392
First Posted:
Jul 14, 2023
Last Update Posted:
Jul 14, 2023
Last Verified:
Jul 1, 2023
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No

Study Results

No Results Posted as of Jul 14, 2023