Oxytocin Effects on the Prosocial Learning

• Sponsor: University of Electronic Science and Technology of China (Other)
• Overall Status: Completed
• CT.gov ID: NCT04105140
• Collaborator: (none)
• Enrollment: 90
• Location: 1
• Arms: 2
• Actual Duration (Months): 7.3
• Patients Per Site Per Month: 12.4

Study Details

Study Description

Brief Summary

To investigate whether intranasal oxytocin (24 IU) treatment can influence prosocial learning behavior in males.

Condition or Disease	Intervention/Treatment	Phase
Healthy	Drug: Oxytocin; Drug: Placebo	N/A

Detailed Description

In a double-blind, within-subject, placebo controlled design, investigators plan to investigate the effect of oxytocin treatment on prosocial learning. Before the self-administration, participants need to finish several questionnaires including IRI, AAS, BASBIS, SPSRQ, SES, PTM, STAI, BDI, ASQ and PNAS. They would finish the PANAS again before the scanning.

Participants are informed that they perform the reward learning task either for themselves, another (unknown) person or no one (control). In the probabilistc reward learning task, associations with two stimuli with different reward probabilities are learned via monetary feedback (reward ￥1 or no reward ￥0). After the experiment, participants need to finish the PANAS.

Study Design

• Study Type: Interventional
• Actual Enrollment: 90 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: Double (Participant, Investigator)
• Primary Purpose: Basic Science
• Official Title: Oxytocin Effects on the Prosocial Learning
• Actual Study Start Date: Jan 1, 2018
• Actual Primary Completion Date: Aug 10, 2018
• Actual Study Completion Date: Aug 10, 2018

Arms and Interventions

Arm	Intervention/Treatment
Experimental: male oxytocin group male subjects with oxytocin treatment	Drug: Oxytocin; intranasal administration of oxytocin (24 IU)
Placebo Comparator: male placebo group male subjects with placebo treatment	Drug: Placebo; intranasal administration of placebo (24 IU)

Outcome Measures

Primary Outcome Measures

1. Neural processing during feedback based on prosocial learning assessed by fMRI scanner [1 hour]

   fMRI BOLD indices of neural processing learning related brain regions will be compared between the treatment administrations.

Secondary Outcome Measures

1. Behavioral learning performance measured by E-prime [1 hour]

   Learning performance will be compared between the treatment administrations by calculating the accuracy of learning.

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 30 Years
• Sexes Eligible for Study: Male
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• without past or current psychiatric or neurological disorders

Exclusion Criteria:

• history of head injury

• medical or psychiatric illness

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	School of Life Science and Technology, University of Electronic Science and Technology of China	Chengdu	Sichuan	China

Sponsors and Collaborators

• University of Electronic Science and Technology of China

Investigators

• Principal Investigator: Keith Kendrick, Dr., University of Electronic Science and Technology of China

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Keith Kendrick, Professor, University of Electronic Science and Technology of China
• ClinicalTrials.gov Identifier: NCT04105140
• Other Study ID Numbers: UESTC-neuSCAN-44
• First Posted: Sep 26, 2019
• Last Update Posted: Sep 26, 2019
• Last Verified: Sep 1, 2019

• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Keywords provided by Keith Kendrick, Professor, University of Electronic Science and Technology of China: oxytocin; prosocial learning
• Additional relevant MeSH terms: Oxytocin

Study Results

No Results Posted as of Sep 26, 2019