The Effect of Aging and Immobilisation on Muscle

• Sponsor: Bispebjerg Hospital (Other)
• Overall Status: Completed
• CT.gov ID: NCT00559806
• Collaborator: (none)
• Enrollment: 20
• Location: 1
• Arms: 2
• Duration (Months): 3.9
• Patients Per Site Per Month: 5.1

Study Details

Study Description

Brief Summary

The debilitating effects of immobilisation on muscle strength and size in young individuals are well documented. Moreover, sarcopenia has long been recognized as a major cause of muscle strength loss in old age, however, changes in muscle mass and architecture with immobilisation in the elderly has not previously been investigated. This is contrasted by the fact that the elderly population more often undergoes periods of immobilization and disuse not only due to joint pain but also due to a higher degree of co morbidity and hospitalisation.The purpose of the present study was to compare the effect of a 2 week period of unilateral immobilisation on the physiological muscle cross sectional area, maximal isometric muscle strength, specific force, muscle fascicle length and muscle fibre pennation angle in young and old healthy men.

Condition or Disease	Intervention/Treatment	Phase
Healthy	Other: 2 weeks of unilateral immobilisation and 4 weeks of resistance training; Other: 2 weeks of unilateral immobilisation and 4 weeks of resistance training	N/A

Study Design

• Study Type: Interventional
• Actual Enrollment: 20 participants
• Allocation: Non-Randomized
• Intervention Model: Parallel Assignment
• Masking: Single (Outcomes Assessor)
• Primary Purpose: Basic Science
• Official Title: The Effect of Aging and Immobilisation on Muscle
• Study Start Date: Jan 1, 2007
• Actual Study Completion Date: May 1, 2007

Arms and Interventions

Arm	Intervention/Treatment
Experimental: 1 9 healthy elderly males	Other: 2 weeks of unilateral immobilisation and 4 weeks of resistance training; 2 weeks of whole leg casting (side randomized)followed by 4 weeks of unilateral resistance training. The non-imm side served as a within-subject control
Experimental: 2 11 healthy young males	Other: 2 weeks of unilateral immobilisation and 4 weeks of resistance training; 2 weeks of unilateral whole leg casting (side randomized)followed by 4 weeks of unilateral resistance training. The non-imm side served as a within-subject control

Outcome Measures

Primary Outcome Measures

1. muscle cross sectional area, maximal isometric muscle strength, specific force, muscle fascicle length and muscle fibre pennation [2 weeks of immobilisation and 4 weeks of resistance training]

Secondary Outcome Measures

1. single muscle fiber area, expression of myostatin and IGF-1 (RNA), changes in satellite activation and number [2 weeks of imm and 4 weeks of resistance training]

Eligibility Criteria

Criteria

• Ages Eligible for Study: 20 Years to 80 Years
• Sexes Eligible for Study: Male
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• Young healthy males (age 20-30 yrs)or old healthy males (age 60-80 yrs)

Exclusion Criteria:

• Musculoskeletal disorder

• Diabetes

• Cardiovascular disease

• Neurological diseases; or

• Cognitive disorders

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Institute of Sports Medicine, Bispebjerg Hospital	Copenhagen		Denmark	2400-NV

Sponsors and Collaborators

• Bispebjerg Hospital

Investigators

• Principal Investigator: Charlotte Suetta, MD, PhD, Institute of Sports Medicine Copenhagen, Bispebjerg Hospital

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• ClinicalTrials.gov Identifier: NCT00559806
• Other Study ID Numbers: KF01-322606
• First Posted: Nov 16, 2007
• Last Update Posted: Nov 16, 2007
• Last Verified: Nov 1, 2007

• Keywords provided by , ,: immobilisation; aging; resistance training; atrophy; The effect of immobilisation in elderly compared to young individuals

Study Results

No Results Posted as of Nov 16, 2007