The Exploration of the Regulatory Effect of Zinc on Intestinal Flora in Healthy Adults
Study Details
Study Description
Brief Summary
In this A Single-center, Prospective, Self-controlled trial, subjects should avoid a high-magnesium diet for 1-3 weeks and take Zinc supplements for 4-6 weeks
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 2 |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Experimental Group During the study period, all subjects were required to avoid a diet high in zinc in order to avoid interference with dietary zinc intake and reduce bias. In weeks 4-6, all subjects were started to receive zinc supplementation at the normal adult dose (zinc tablets: 1 tablet (50mg) once daily after meals), while maintaining the avoidance of high-zinc foods. |
Dietary Supplement: Zinc Gluconate
Each participant should receive a high-magnesium diet for 1-3 weeks and take magnesium supplements for 4-6 weeks.
|
Outcome Measures
Primary Outcome Measures
- 16S rDNA sequencing [42 days]
16S rDNA sequencing technology was used to identify the structural and functional changes of intestinal microbiota before and after Zinc supplementation.
- metabolomic analysis of serum and feces [42 days]
To determine the alteration of gut microbiota after Zn supplementary.
Secondary Outcome Measures
- The serum levels of Zn2+ in each study phase [42 days]
The serum levels of Zn2+ would be detected on day 0, day 21 and day 42.
Eligibility Criteria
Criteria
Inclusion Criteria:
- Healthy adults aged 20-30 years from the general community were recruited to participate in the study voluntarily without underlying diseases.
Exclusion Criteria:
Patients who have taken antibiotics orally in the past 3 months or have acute or chronic inflammation; Those who have taken hormones within 3 months; Have taken any drugs that may interfere with glucose and lipid metabolism (such as insulin, glyburide, indomethacin, phentolamine, fuuside, phenytoin sodium, cortisone, etc.) and have had probiotic intervention within 1 month; smokers and drinkers; Uncontrollable mental disorders (including hospitalization history of mental illness); (6) Currently attending a weight loss or weight management course; prescribed diet for specific or other reasons (e.g. celiac disease); pregnant or lactating women; Patients with cardiac and renal insufficiency; Patients with other underlying diseases; Long-term constipation.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Southern Medical Unversity，the seventh affiliated hospital | Foshan | Guangdong | China | 528000 |
Sponsors and Collaborators
- The Seventh Affiliated Hospital, Southern Medical University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Additional Information:
Publications
- (2022)--0008