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Oxytocin and Emotion Processing

Sponsor
University Hospital, Bonn (Other)
Overall Status
Completed
CT.gov ID
NCT02156661
Collaborator
(none)
97
Enrollment
2
Arms
13
Duration (Months)

Study Details

Study Description

Brief Summary

The purpose of this study is to determine whether oxytocin influences emotional processing and learning of emotional and social stimuli.

Condition or Disease Intervention/Treatment Phase
Phase 1

Detailed Description

An effect of OXT on emotion processing and anxiety has been broadly investigated in animal studies. However, in humans, effects seem more complex.

The rationale of the study is to examine direct effects of OXT to processing and learning of emotional and social values in humans.

Study Design

Study Type:
Interventional
Actual Enrollment :
97 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose:
Treatment
Study Start Date :
May 1, 2013
Actual Primary Completion Date :
Jun 1, 2014
Actual Study Completion Date :
Jun 1, 2014

Arms and Interventions

Arm Intervention/Treatment
Active Comparator: Oxytocin

Oxytocin: Syntocinon-Spray, Novartis intranasal administration, 24 IU oxytocin; ; 3 puffs per nostril, each with 4 IU OXT

Drug: Oxytocin
Placebo Comparator: Placebo

Placebo nasal spray

Drug: Oxytocin

Outcome Measures

Primary Outcome Measures

  1. Brain activity [During emotion processing]

    fMRI

Secondary Outcome Measures

  1. Psychophysiological response [During stimuli presentation]

    Skin conductance response

Eligibility Criteria

Criteria

Ages Eligible for Study:
20 Years to 40 Years
Sexes Eligible for Study:
Male
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:
  • Healthy male volunteers
Exclusion Criteria:

  • Current or past psychiatric disease

  • Current or past physical illness

  • Psychoactive medication

  • Tobacco smokers

  • MRI contraindication

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

  • University Hospital, Bonn

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Rene Hurlemann, Professor, University Hospital, Bonn
ClinicalTrials.gov Identifier:
NCT02156661
Other Study ID Numbers:
  • OXT-FC-14
First Posted:
Jun 5, 2014
Last Update Posted:
May 9, 2017
Last Verified:
May 1, 2017
Additional relevant MeSH terms:
Oxytocin

Study Results

No Results Posted as of May 9, 2017