The Effects of Caffeine on Pain-Based Pacing During a Cycling Time-Trial

Sponsor

University of Oklahoma (Other)

Overall Status

Completed

CT.gov ID

NCT02115763

Collaborator

(none)

Enrollment

Location

Arm

Actual Duration (Months)

1.2

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Caffeine has been shown to consistently improve time-trial performance, warranting restrictions on consumption under regulation of the National Collegiate Athletics Association (NCAA) and World Anti-Doping Agency (WADA). This ergogenic effect is not well understood, possibly occurring as a result of altered metabolism, improved strength, and/or reduced muscle pain. The hypothesis of altered metabolism has recently fallen out of favor while muscular strength has a tenuous relationship with endurance exercise performance. Reductions in muscle pain have been observed during low and moderate intensity endurance exercise, and this may be the mechanism of caffeine's ergogenic effect. In lieu of reducing pain during high intensity exercise, caffeine significantly improves performance. Therefore, caffeine appears to improve the amount of work that can be done for a given muscle pain rating, suggesting that participants may pace based upon sensations of muscle pain during endurance exercise. Most time-trial exercise is conducted in a fixed distance manner, measuring the time it takes participants to cover a given distance. Little research has been conducted on a fixed pain time-trial that would require participants to produce and sustain a given level of muscle pain while measuring the distance covered in an allotted time. A fixed pain time-trial could allow researchers to better understand the effect of pain on endurance performance. The purpose of this study is to examine the effects of caffeine on a fixed pain time-trial.

Condition or Disease	Intervention/Treatment	Phase
Healthy	Drug: Caffeine Drug: Placebo	Phase 1

Study Design

Study Type:

Interventional

Actual Enrollment :

15 participants

Allocation:

N/A

Intervention Model:

Single Group Assignment

Masking:

Single (Participant)

Primary Purpose:

Basic Science

Official Title:

The Effects of Caffeine on Pain-Based Pacing During a Cycling Time-Trial

Actual Study Start Date :

Apr 1, 2014

Actual Primary Completion Date :

May 1, 2015

Actual Study Completion Date :

May 1, 2015

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Caffeine There is only one arm, it receives both caffeine and placebo.	Drug: Caffeine Drug: Placebo

Arm

Intervention/Treatment

Experimental: Caffeine

There is only one arm, it receives both caffeine and placebo.

Drug: Caffeine

Drug: Placebo

Outcome Measures

Primary Outcome Measures

Stationary Cycle Ergometer [30 minutes per session (6 sessions total)]
The distance covered (meters) while exercising on the cycle ergometer will be recorded.

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 35 Years

Sexes Eligible for Study:

Male

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Caffeine Naive (<40mg per day) physically active 18-35 year old men with no contraindications to exercise.

Exclusion Criteria:

People who do not match the gender, age or caffeine limits;
those with contraindications to exercise or who are not physically active

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	University of Oklahoma Sensory and Muscle Function Lab	Norman	Oklahoma	United States	73019

Sponsors and Collaborators

University of Oklahoma

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

University of Oklahoma

ClinicalTrials.gov Identifier:

NCT02115763

Other Study ID Numbers:

4084

First Posted:

Apr 16, 2014

Last Update Posted:

Jun 5, 2017

Last Verified:

Jun 1, 2017

Keywords provided by University of Oklahoma

physically active,

18-35 year old men

Additional relevant MeSH terms:

Caffeine

Study Results

No Results Posted as of Jun 5, 2017